selected scholarly activity
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academic article
- Sputum cytology during late-phase responses to inhalation challenge with different allergens. Allergy: European Journal of Allergy and Clinical Immunology. 73:1470-1478. 2018
- Effects of bidi smoking on all-cause mortality and cardiorespiratory outcomes in men from south Asia: an observational community-based substudy of the Prospective Urban Rural Epidemiology Study (PURE). The Lancet Global Health. 5:e168-e176. 2017
- Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses. Journal of Allergy and Clinical Immunology. 138:1051-1059. 2016
- Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma. American Journal of Respiratory and Critical Care Medicine. 194:169-177. 2016
- The Effects of Repeated Bronchoprovocation on FEV1in Subjects with Asthma. Annals of the American Thoracic Society. 12:1589-1591. 2015
- Comparison of the Provocative Concentration of Methacholine Causing a 20% Fall in FEV1between the AeroEclipse II Breath-Actuated Nebulizer and the Wright Nebulizer in Adult Subjects with Asthma. Annals of the American Thoracic Society. 12:1039-1043. 2015
- A Nonsteroidal Glucocorticoid Receptor Agonist Inhibits Allergen-induced Late Asthmatic Responses. American Journal of Respiratory and Critical Care Medicine. 191:161-167. 2015
- OX40L blockade and allergen-induced airway responses in subjects with mild asthma. Clinical and Experimental Allergy. 44:29-37. 2014
- Global differences in lung function by region (PURE): an international, community-based prospective study. The Lancet Respiratory Medicine. 1:599-609. 2013
- The effects of particle size on measurement of airway hyperresponsiveness to methacholine. Annals of Allergy, Asthma and Immunology. 110:359-363. 2013
- Comparison of changes in lung function measured by plethymography and IOS after bronchoprovocation. Respiratory Medicine. 107:503-510. 2013
- Effects of Dehydration during Cycling on Skeletal Muscle Metabolism in Females. Medicine and Science in Sports and Exercise Medicine and science in sports. 44:1949-1957. 2012
- Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects. Respiratory Research. 12:140. 2011
- Interleukin-18 and interleukin-18 receptor- expression in allergic asthma. European Respiratory Journal European Respiratory Journal, Supplement. 38:981-983. 2011
- Dose-response effects of TPI ASM8 in asthmatics after allergen. Allergy: European Journal of Allergy and Clinical Immunology. 66:1242-1248. 2011
- Sputum inflammatory cells and allergen-induced airway responses in allergic asthmatic subjects. Allergy: European Journal of Allergy and Clinical Immunology. 66:1075-1080. 2011
- Effects of Interleukin-13 Blockade on Allergen-induced Airway Responses in Mild Atopic Asthma. American Journal of Respiratory and Critical Care Medicine. 183:1007-1014. 2011
- A study of the physiologic responses to a lung recruitment maneuver in acute lung injury and acute respiratory distress syndrome.. Respiratory Care. 53:1441-1449. 2008
- Airway smooth muscle as a target of asthma therapy: history and new directions. Respiratory Research. 7:123. 2006
- Effects of inhaled ciclesonide on circulating T-helper type 1/T-helper type 2 cells in atopic asthmatics after allergen challenge. Clinical and Experimental Allergy. 36:1417-1424. 2006
- Dyspnea. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 101:1013-1014. 2006
- Comment on Point:Counterpoint "Supraspinal locomotor centers do/do not contribute significantly to the hyperpnea of dynamic exercise in humans". Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 100:1743-1747. 2006
- Point: Counterpoint comments - Supraspinal locomotor centers do/do not contribute significantly to the hyperpnea of dynamic exercise in humans. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 100:1746-1746. 2006
- Supraspinal locomotor centers do/do not contribute significantly to the hyperpnea of dynamic exercise in humans.. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 100:1746. 2006
- Limitation to muscular activity in chronic obstructive pulmonary disease. European Respiratory Journal European Respiratory Journal, Supplement. 24:6-7. 2004
- The effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthma. Journal of Allergy and Clinical Immunology. 112:331-338. 2003
- Is exercise tolerance limited by the heart or the lungs?. Clinical and Investigative Medicine. 24:110-117. 2001
- Exercise Limitation in Health and Disease. New England Journal of Medicine. 343:632-641. 2000
- Mechanisms of disease: Exercise limitation in health and disease. New England Journal of Medicine. 343:632-641. 2000
- Symptom Perception during Acute Bronchoconstriction. American Journal of Respiratory and Critical Care Medicine. 162:490-496. 2000
- Is there a conflict between minimizing effort and energy expenditure with increasing velocities of muscle contraction in humans?. Journal of Physiology. 518:933-940. 1999
- Measurements of dyspnoea during bronchoconstriction. European Respiratory Journal European Respiratory Journal, Supplement. 13:943-943. 1999
- Dyspnea. American Journal of Respiratory and Critical Care Medicine. 159:321-340. 1999
- Sense of effort and dyspnoea.. Monaldi Archives for Chest Disease. 53:654-660. 1998
- Metabolic and hemodynamic responses of lower limb during exercise in patients with COPD. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 84:1573-1580. 1998
- Symptom Intensity and Subjective Limitation to Exercise in Patients With Cardiorespiratory Disorders. Chest. 110:1255-1263. 1996
- Quantification of intensity of sensations during muscular work by normal subjects. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 81:1156-1161. 1996
- MUSCLE STRENGTH, SYMPTOM INTENSITY, AND EXERCISE CAPACITY IN PATIENTS WITH CARDIORESPIRATORY DISORDERS. American Journal of Respiratory and Critical Care Medicine. 152:2021-2031. 1995
- Muscle strength, symptom intensity, and exercise capacity in patients with cardiorespiratory disorders.. American Journal of Respiratory and Critical Care Medicine. 152:2021-2031. 1995
- Mechanisms of exertional dyspnea.. Clinics in Chest Medicine. 15:247-257. 1994
- Respiratory sensations, cardiovascular control, kinaesthesia and transcranial stimulation during paralysis in humans.. Journal of Physiology. 470:85-107. 1993
- Factors Determining Pulmonary Function in Adolescent Idiopathic Thoracic Scoliosis. American Review of Respiratory Disease. 148:288-294. 1993
- Factors Influencing Work Capacity in Adolescent Idiopathic Thoracic Scoliosis. American Review of Respiratory Disease. 148:295-300. 1993
- Factors contributing to dyspnoea during bronchoconstriction and exercise in asthmatic subjects.. European Respiratory Journal European Respiratory Journal, Supplement. 6:1004-1010. 1993
- Exercise Capacity and Ventilatory, Circulatory, and Symptom Limitation in Patients with Chronic Airflow Limitation. American Review of Respiratory Disease. 146:935-940. 1992
- Dyspnea and Leg Effort during Incremental Cycle Ergometry. American Review of Respiratory Disease. 145:1339-1345. 1992
- Randomised controlled trial of weightlifting exercise in patients with chronic airflow limitation.. Thorax. 47:70-75. 1992
- Breathing during prolonged exercise in humans.. Journal of Physiology. 442:477-487. 1991
- Effort and dyspnoea during work of varying intensity and duration.. European Respiratory Journal European Respiratory Journal, Supplement. 4:917-925. 1991
- Assessment of disability.. European Respiratory Journal European Respiratory Journal, Supplement. 3:989-990. 1990
- Methacholine Airway Responsiveness Decreases during Exercise in Asthmatic Subjects. American Review of Respiratory Disease. 141:1414-1417. 1990
- Influence of Age and Stature on Exercise Capacity during Incremental Cycle Ergometry in Men and Women. American Review of Respiratory Disease. 140:1373-1380. 1989
- Inspiratory muscles during exercise: a problem of supply and demand. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 64:2482-2489. 1988
- Respiratory muscles and dyspnea.. Clinics in Chest Medicine. 9:237-248. 1988
- Effect of thoracoabdominal breathing patterns on inspiratory effort sensation. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 62:1665-1670. 1987
- Breathlessness during exercise with and without resistive loading. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 61:896-905. 1986
- BREATHLESSNESS AND EXERCISE IN PATIENTS WITH CARDIORESPIRATORY DISEASE. American Review of Respiratory Disease. 133:945-946. 1986
- LOADED BREATHING - LOAD COMPENSATION AND RESPIRATORY SENSATION. FASEB Journal. 45:114-122. 1986
- Breathlessness and Exercise in Patients with Cardiorespiratory Disease1–3. American Review of Respiratory Disease. 133:21-25. 1986
- The Objective Measurement of Breathlessness. Chest. 88:84S-90S. 1985
- Effect of frequency on perceived magnitude of added loads to breathing. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 58:1616-1621. 1985
- Inspiratory muscle forces and endurance in maximum resistive loading. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 58:1608-1615. 1985
- Alveolar gas exchange during exercise: a single-breath analysis. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 57:1704-1709. 1984
- Effect of increased lung volume on perception of breathlessness, effort, and tension. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 57:686-691. 1984
- The use of exercise testing and other methods in the investigation of dyspnea.. Clinics in Chest Medicine. 5:99-108. 1984
- Dyspnea and Exercise. Annual Review of Physiology. 45:465-479. 1983
- Pattern of breathing during exercise in patients with interstitial lung disease.. Thorax. 38:778-784. 1983
- Effect of background loads on the perception of added loads to breathing. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 54:1222-1228. 1983
- Psychophysics of inspiratory muscle force. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 54:1216-1221. 1983
- Theory of resistive load detection. Respiration Physiology. 51:131-139. 1983
- Weber’s Law and Resistive Load Detection1–3. American Review of Respiratory Disease. 127:5-7. 1983
- The perception of breathlessness in asthma.. American Review of Respiratory Disease. 126:825-828. 1982
- Effect of ventilatory drive on the perceived magnitude of added loads to breathing. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 53:901-907. 1982
- Detection Latency of Added Loads to Breathing. Clinical Science. 63:11-15. 1982
- Effect of breathing patterns on the perceived magnitude of added loads to breathing. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 52:578-584. 1982
- The Contribution of Upper Airway and Inspiratory Muscle Mechanisms to the Detection of Pressure Changes at the Mouth in Normal Subjects. Clinical Science. 60:513-518. 1981
- The qunatification of respiratory sensations by normal subjects. Respiration Physiology. 44:251-260. 1981
- The Effect of Respiratory Muscle Fatigue on Respiratory Sensations. Clinical Science. 60:463-466. 1981
- Magnitude scaling of externally added loads to breathing.. American Review of Respiratory Disease. 123:12-15. 1981
- Changes in the perception of inspiratory resistive loads during partial curarization.. Journal of Physiology. 309:93-100. 1980
- Effect of timing, flow, lung volume, and threshold pressures on resistive load detection. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 49:958-963. 1980
- Resistive Load Detection during Passive Ventilation. Clinical Science. 59:493-495. 1980
- The effect of increased ventilation on resistive load discrimination.. American Review of Respiratory Disease. 120:1233-1238. 1979
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conference paper
- Asthma, Chronic Obstructive Pulmonary Disease, Respiratory Tract Infections And Viruses: Admission Rates, Emergency Room Visits And Age. American Journal of Respiratory and Critical Care Medicine. 2017
- Contribution Of Fev1 To Exercise Performance In Health And Disease. American Journal of Respiratory and Critical Care Medicine. 2017
- Rates Of Hospital Admission And Emergency Room Visits With Asthma, Chronic Obstructive Pulmonary Disease, And Respiratory Tract Infection Relative To Age And Season In Ontario, Canada. American Journal of Respiratory and Critical Care Medicine. 2017
- The Contribution Of Ventilatory Capacity, Gas Transfer Capacity And The Presence Of Airflow Obstruction To Limitations In Maximum Power Output. American Journal of Respiratory and Critical Care Medicine. 2016
- A Predictive Model For Determining The Efficacy Of Multiple Doses Of Qge031 (ligelizumab) Versus Omalizumab And Placebo In Inhibiting The Allergen-Induced Early Asthmatic Response. American Journal of Respiratory and Critical Care Medicine. 2015
- Cardiovascular Responses During Exercise With Increasing Smoking Exposure. American Journal of Respiratory and Critical Care Medicine. 2015
- Exercise And Smoking Exposure: Limiting Symptom. American Journal of Respiratory and Critical Care Medicine. 2015
- Oxygen Extraction During Exercise With Increasing Smoking Exposure. American Journal of Respiratory and Critical Care Medicine. 2015
- Reduced Exercise Tolerance With Increasing Smoking Exposure. American Journal of Respiratory and Critical Care Medicine. 2015
- Ventilatory Responses During Exercise With Increasing Smoking Exposure. American Journal of Respiratory and Critical Care Medicine. 2015
- Comparison Of The Methacholine Pc20 Between The Trudell Aeroeclipse Ii Ban Nebuliser And The Wright Nebuliser In Adult Asthmatic Subjects. American Journal of Respiratory and Critical Care Medicine. 2014
- Disability And Symptom Handicap With Increasing Smoking Exposure. American Journal of Respiratory and Critical Care Medicine. 2014
- Exercise Performance From The Perspective Of Quadriceps Strength. American Journal of Respiratory and Critical Care Medicine. 2014
- Prevalence Of Myocardial Infarction And Chronic Airflow Limitation With Smoking Exposure. American Journal of Respiratory and Critical Care Medicine. 2014
- Pulmonary Function With Increasing Smoking Exposure. American Journal of Respiratory and Critical Care Medicine. 2014
- Repeated Methacholine Bronchoprovocation Does Not Affect Baseline Fev1. American Journal of Respiratory and Critical Care Medicine. 2014
- The Dose-Response Effect Of Cigarette Smoking On Chronic Airflow Limitation (cal) Prevalence Across The World: The Pure-Breath Study. American Journal of Respiratory and Critical Care Medicine. 2014
- The Global Prevalence Of Dyspnea And Its Contributing Factors: The Pure-Breath Study. American Journal of Respiratory and Critical Care Medicine. 2014
- What Is A Clinically Meaningful Change In Fev1?. American Journal of Respiratory and Critical Care Medicine. 2014
- Blood Pressure Changes During Exercise Are Correlated To The Magnitude Of Airflow Obstruction In Chronic Obstructive Pulmonary Disease (COPD). American Journal of Respiratory and Critical Care Medicine. 2013
- Contribution Of Muscle Strength And Obesity To Dyspnea-Induced Exercise Limitation. American Journal of Respiratory and Critical Care Medicine. 2013
- Contribution Of Muscle Strength And Obesity To Perceived Intensity Of Dyspnea. American Journal of Respiratory and Critical Care Medicine. 2013
- TPI ASM8 Decreases Inflammatory Markers and Improves Airway Responsiveness in Asthmatics. Journal of Allergy and Clinical Immunology. AB82-AB82. 2011
- Quadriceps Strength Relative To Body Weight. American Journal of Respiratory and Critical Care Medicine. 2011
- PULMONARY AND MUSCULAR IMPAIRMENT: CHRONIC OBSTRUCTIVE PULMONARY DISEASE VERSUS MYOCARDIAL INFARCTION OF INCREASING SEVERITY. Canadian Journal of Cardiology. 27D-27D. 2010
- Can Changes In Sputum Inflammatory Cells Predict The Allergen-induced Airway Hyperresponsiveness In Allergic Asthmatic Subjects?. American Journal of Respiratory and Critical Care Medicine. 2010
- Can Sputum Eosinophils, Neutrophils Or Macrophages Predict The Severity Of Bronchoconstriction Following Allergen Inhalation?. American Journal of Respiratory and Critical Care Medicine. 2010
- Efficacy of Increasing Doses of TPI ASM8 on Allergen Inhalation Challenges in Asthmatics. American Journal of Respiratory and Critical Care Medicine. 2010
- Increased Lung-Homing of Vascular Endothelial Progenitor Cells in Asthmatic Subjects Following Allergen Inhalation Challenge. American Journal of Respiratory and Critical Care Medicine. 2010
- Pulmonary and Muscular Impairment: COPD vs. Myocardial Infarction of Increasing Severity. American Journal of Respiratory and Critical Care Medicine. 2010
- Resting Acid/Base Balance and the Capacity to Exercise. American Journal of Respiratory and Critical Care Medicine. 2010
- VITAL CAPACITY PREDICTION EQUATIONS FAIL TO CONFORM TO BIOLOGICAL REALITY. American Journal of Respiratory and Critical Care Medicine. 2010
- The effect of C5 inhibition by eculizumab on allergen-induced asthmatic responses in patients. Molecular Immunology. 2837-2838. 2009
- Airway Neutrophilia after Allergen Challenge in Subjects with Atopic Asthma.. American Journal of Respiratory and Critical Care Medicine. 2009
- Association of Oxygen Uptake Measured at the Mouth with the Capacity to Exercise, Intensity of Dyspnea, Leg Effort, and RER. American Journal of Respiratory and Critical Care Medicine. 2009
- Dyspnea during Exercise in COPD: Change in VE vs. Change in MBC. American Journal of Respiratory and Critical Care Medicine. 2009
- Lung Volume and Flow Rates: Interaction of Obesity and Respiratory Muscle Strength. American Journal of Respiratory and Critical Care Medicine. 2009
- Myeloid and Plasmacytoid Dendritic Cells in Sputum Following Allergen Challenge in Allergic Asthmatic Subjects. American Journal of Respiratory and Critical Care Medicine. 2009
- Oxygen Uptake at the Same Power in Normals &COPD. American Journal of Respiratory and Critical Care Medicine. 2009
- Safety of Allergen Inhalation Challenge in Allergic Asthmatic Subjects.. American Journal of Respiratory and Critical Care Medicine. 2009
- The effect of C5 inhibition by eculizumab on allergen-induced asthmatic responses. Allergy: European Journal of Allergy and Clinical Immunology. 16-16. 2009
- The effects of inhaled budesonide and formoterol in combination and alone when given directly after allergen challenge. Journal of Allergy and Clinical Immunology. 322-327. 2007
- Asthma symptoms following low dose allergen exposure. American Journal of Respiratory and Critical Care Medicine. A653-A653. 1999
- SYMPTOM LIMITATION AND SENSORY MAGNITUDE OF LEG EFFORT AND DYSPNEA DURING EXERCISE. American Review of Respiratory Disease. A549-A549. 1993
- SYMPTOM LIMITATIONS DURING A PROGRESSIVE INCREMENTAL EXERCISE TEST. American Review of Respiratory Disease. A189-A189. 1993
- EXERCISE IN CHRONIC AIRWAY-OBSTRUCTION. EXERCISE, FITNESS, AND HEALTH. 547-559. 1990
- EFFECT OF VELOCITY AND EXTENT OF SHORTENING ON THE PERCEIVED MAGNITUDE OF RESPIRATORY MUSCLE EFFORT. American Review of Respiratory Disease. A189-A189. 1986
- FACTORS CONTRIBUTING TO THE ALLEVIATION OF BREATHLESSNESS BY EXERCISE TRAINING IN CORONARY HEART-DISEASE. American Review of Respiratory Disease. A190-A190. 1986
- IS THE FREQUENCY OF BREATHING DETERMINED BY MINIMUM WORK OR PEAK FORCE. American Review of Respiratory Disease. A29-A29. 1986
- EFFECT OF PATTERNS OF RESPIRATORY MUSCLE RECRUITMENT ON THE SENSATION OF INSPIRATORY EFFORT. Europeen de physiopathologie respiratoire, Bulletin. S21-S21. 1986
- FACTORS CONTRIBUTING TO DYSPNEA DURING MAXIMAL EXERCISE. Medicine and Science in Sports and Exercise Medicine and science in sports. 130-130. 1984
- THE SENSE OF EFFORT, OXYGEN COST AND PATTERN OF BREATHING ASSOCIATED WITH PROGRESSIVE ELASTIC LOADING TO FATIGUE. FASEB Journal. 528-528. 1984
- USEFULNESS OF DETERMINATION OF ESOPHAGEAL PRESSURE IN EVALUATION OF BREATHLESSNESS IN NORMAL SUBJECTS. FASEB Journal. 430-430. 1984
- THE EFFECT OF RESPIRATORY FREQUENCY ON THE PERCEIVED MAGNITUDE OF ADDED LOADS TO BREATHING. American Review of Respiratory Disease. 234-234. 1983
- THE PATTERN OF BREATHING DURING EXERCISE IN PATIENTS WITH INTERSTITIAL LUNG-DISEASE. Australian and New Zealand Journal of Medicine. 555-556. 1983
- THE PERCEPTION OF BREATHLESSNESS IN ASTHMA. Clinical and Experimental Pharmacology and Physiology. 457-458. 1983
- THE ROLE OF PERCEIVED EFFORT IN THE OPTIMIZATION OF RESPIRATORY PATTERN WITH INCREASING RESISTIVE LOADS TO BREATHING. FASEB Journal. 328-328. 1983
- THE SENSE OF EFFORT, OXYGEN COST AND PATTERN OF VENTILATION ASSOCIATED WITH PROGRESSIVE RESISTIVE LOADING TO FATIGUE. FASEB Journal. 330-330. 1983
- THE EFFECT OF AN INSPIRATORY PAUSE ON THE WASHOUT DEADSPACE AT REST AND DURING EXERCISE. American Review of Respiratory Disease. 253-253. 1982
- THE PSYCHOPHYSICS OF INSPIRATORY MUSCLE FORCE. FASEB Journal. 989-989. 1982
- DOES RESISTIVE LOAD DETECTION OBEY WEBER LAW OVER A WIDE-RANGE OF BACKGROUND RESISTANCES. FASEB Journal. 386-386. 1981
- MOMENT ANALYSIS APPLIED TO EXPIRED ALVEOLAR GASES. FASEB Journal. 383-383. 1981
- REACTION-TIME TO ADDED INSPIRATORY LOADS. FASEB Journal. 386-386. 1981
- CHANGES IN THE PERCEPTION OF INSPIRATORY RESISTIVE LOADS DURING PARTIAL CURARIZATION. FASEB Journal. 278-278. 1980
- THEORY OF RESISTIVE LOAD DETECTION (RLD). FASEB Journal. 836-836. 1980
- IMPORTANCE OF THE EARLY PART OF THE BREATH IN RESISTIVE LOAD DETECTION. FASEB Journal. 1299-1299. 1979
- EFFECT OF INCREASED VENTILATION ON RESISTIVE LOAD DETECTION. Clinical Research. A878-A878. 1978