Anne Marie Holbrook
Professor, Medicine

Education and Professional Standing
Dr. Holbrook is a Professor in the Department of Medicine and the Director of the Division of Clinical Pharmacology & Toxicology. Her clinical practice combines Clinical Pharmacology and Internal Medicine services and specializes in the care of hospitalized adults with major, multiple comorbidities, and complex or high-risk medication regimens.
She is an international leader in promoting evidence-based therapeutics through research and education, including randomized trials to improve medication safety. She regularly supervises and mentors medical, pharmacy and research trainees at all stages of development, work that was recently recognized with an inaugural Department of Medicine teaching award. She is an international leader in improving trainee competence in evidence-based prescribing.
Anne is one of the most experienced expert advisors of drug policy in Canada, influencing all levels of government and budgets in excess of $5 billion annually. Sustainable implementation of national Pharmacare is a current priority. She has been at the top of McMaster’s academic productivity ratings since the program’s inception.

Research Interests
Dr. Holbrook's main research area is evidence-based therapeutics, with current or recent studies on personalizing benefit: harm information for individual patients, cost-related nonadherence, patient preferences for high impact drugs using decision aids, pharmacoepidemiology using linked health databases, pragmatic randomized trials of post-discharge management of high-risk medications, systematic reviews of drug interaction impact on clinical outcomes, investigation of medication funding for vulnerable groups across Canada, and assessment of prescribing competency.

She was the recipient of a Career Investigator award from the Canadian Institutes for Health Research for innovation in decision-making for patients, practitioners, and policymakers. She maintains a CIHR Principal Investigator grant track record and without ties to commercial interests. She remains the lead of Canada's original electronic medical record research network (COMPETE) which develops, implements, and evaluates various e-health initiatives directed at improving the quality of therapeutics.
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  • PHONE: 905-525-9140 ext. 35269
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