Journal article
Vitamin K for reversal of excessive vitamin K antagonist anticoagulation: a systematic review and meta-analysis
Abstract
Patients receiving vitamin K antagonists (VKAs) with an international normalized ratio (INR) between 4.5 and 10 are at increased risk of bleeding. We systematically reviewed the literature to evaluate the effectiveness and safety of administering vitamin K in patients receiving VKA therapy with INR between 4.5 and 10 and without bleeding. Medline, Embase, and Cochrane databases were searched for relevant randomized controlled trials in April …
Authors
Khatib R; Ludwikowska M; Witt DM; Ansell J; Clark NP; Holbrook A; Wiercioch W; Schünemann H; Nieuwlaat R
Journal
Blood Advances, Vol. 3, No. 5, pp. 789–796
Publisher
American Society of Hematology
Publication Date
March 12, 2019
DOI
10.1182/bloodadvances.2018025163
ISSN
2473-9529