Journal article
Endothelin-1 antagonism and nitric oxide augmentation prevents cyclosporine-induced vasomotor impairment
Abstract
BACKGROUND: We previously demonstrated that cyclosporine (CyA) impairs endothelial function as a result of alterations in nitric oxide (NO) and endothelin-1 (ET-1) regulation. Bosentan (BOS), an ET-1 antagonist, and tetrahydrobiopterin (BH₄), an eNOS cofactor, may reduce endothelial dysfunction by improving ET-1/NO homeostasis.
METHODS: Lewis rats received intraperitoneal injections of CyA with BOS or with BOS+BH₄ daily for 2 weeks. Control …
Authors
Ramzy D; Wallen J; Badiwala MV; Tumiati LC; Tepperman E; Ross HJ; Delgado DH; Rao V
Journal
The Journal of Heart and Lung Transplantation, Vol. 30, No. 1, pp. 77–85
Publisher
Elsevier
Publication Date
1 2011
DOI
10.1016/j.healun.2010.08.001
ISSN
1053-2498