Endpoint Determination Concept

subject area of

• A Randomised, Double Blind, Placebo-controlled Study to Determine the Efficacy of Immune Modulation Therapy in the Treatment of Patients Suffering from Peripheral Arterial Occlusive Disease with Intermittent Claudication  Journal Articles
• A comparison of a new multinomial stopping rule with stopping rules of fleming and gehan in single arm phase II cancer clinical trials  Journal Articles
• A randomized phase 2 study of a HSP27 targeting antisense, apatorsen with prednisone versus prednisone alone, in patients with metastatic castration resistant prostate cancer  Journal Articles
• A review of potential methods of determining critical effect size for designing environmental monitoring programs  Journal Articles
• Accounting for treatment by center interaction in sample size determinations and the use of surrogate outcomes in the pessary for the prevention of preterm birth trial: a simulation study  Journal Articles
• Added value of health-related quality of life measurement in cancer clinical trials: the experience of the NCIC CTG  Journal Articles
• An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis  Journal Articles
• Assessment of clinically relevant bleeding as a surrogate outcome for major bleeding: validation by meta‐analysis of randomized controlled trials  Journal Articles
• Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? Reflections From aDiabetes CareEditors’ Expert Forum  Journal Articles
• Cinacalcet normalizes serum calcium in a double-blind randomized, placebo-controlled study in patients with primary hyperparathyroidism with contraindications to surgery  Journal Articles
• Clinical Models to Compare the Safety and Efficacy of Inhaled Corticosteroids in Patients with Asthma  Journal Articles
• Common Sense Oncology principles for the design, analysis, and reporting of phase 3 randomised clinical trials.  Journal Articles
• Comparison of Outcomes of Phase II Studies and Subsequent Randomized Control Studies Using Identical Chemotherapeutic Regimens  Conferences
• Consistency in the Analysis and Reporting of Primary End Points in Oncology Randomized Controlled Trials From Registration to Publication: A Systematic Review  Journal Articles
• Critical body residues, Michaelis–Menten analysis of bioaccumulation, lethality and behaviour as endpoints of waterborne Ni toxicity in two teleosts  Journal Articles
• Cytogenetic dose–response and adaptive response in cells of ungulate species exposed to ionizing radiation  Journal Articles
• Development of a Core Outcome Set for Studies on Cardiac Disease in Pregnancy (COSCarP): a study protocol  Journal Articles
• Development of a Core Outcome Set for Studies on Obesity in Pregnant Patients (COSSOPP): a study protocol  Journal Articles
• Effect of Reversal of Neuromuscular Blockade with Sugammadex versus Usual Care on Bleeding Risk in a Randomized Study of Surgical Patients  Journal Articles
• Effect of Rosiglitazone on Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease  Journal Articles
• Efficacy of pharmacological therapies in patients with IBS with diarrhoea or mixed stool pattern: systematic review and network meta-analysis  Journal Articles
• Empirical estimation of disutilities and decision thresholds for composite endpoints.  Journal Articles
• Endpoints in myelin-deficient (MD) rats.  Journal Articles
• Establishing the appropriate primary endpoint in haemophilia gene therapy pivotal studies  Journal Articles
• Evaluation of GERD Symptoms during Therapy. Part I  Journal Articles
• Evaluation of GERD Symptoms during Therapy. Part II  Journal Articles
• Evaluation of Short-Term Changes in Serum Creatinine Level as a Meaningful End Point in Randomized Clinical Trials  Journal Articles
• Evolution of Clinical Trials Registries  Journal Articles
• FDA ovarian cancer clinical trial endpoints workshop: A Society of Gynecologic Oncology White Paper  Journal Articles
• Fluid Lavage of Open Wounds (FLOW): design and rationale for a large, multicenter collaborative 2 × 3 factorial trial of irrigating pressures and solutions in patients with open fractures  Journal Articles
• GFR Decline as an Alternative End Point in Clinical Trials to Prevent ESRD: Are We Increasing Treatment Uncertainty for the Sake of Feasibility?  Journal Articles
• GRADE Leitlinien: 13. Erstellen von Summary-of-Findings-Tabellen und Evidenzprofilen – kontinuierliche Endpunkte  Journal Articles
• GRADE Leitlinien: 7. Einschätzung der Qualität der Evidenz – Inkonsistenz  Journal Articles
• GRADE Leitlinien: 8. Einschätzung der Qualität der Evidenz – Indirektheit  Journal Articles
• GRADE guidelines 27: how to calculate absolute effects for time-to-event outcomes in summary of findings tables and Evidence Profiles  Journal Articles
• GRADE-Leitlinien: 1. Einführung – GRADE-Evidenzprofile und Summary-of-Findings-Tabellen  Journal Articles
• GRADE-Leitlinien: 12. Erstellen von „Summary-of-Findings“-Tabellen – Dichotome Endpunkte  Journal Articles
• GRADE-Leitlinien: 2. Formulierung der Fragestellung und Entscheidung über wichtige Endpunkte  Journal Articles
• GRADE-Leitlinien: 4. Bewertung der Qualität der Evidenz – Studienlimitationen (Risiko für Bias)  Journal Articles
• Global haemostasis and point of care testing  Journal Articles
• Guidelines for fracture healing assessments in clinical trials. Part I: Definitions and endpoint committees  Journal Articles
• Guidelines for fracture healing assessments in clinical trials. Part II: Electronic data capture and image management systems—Global Adjudicator™ system  Journal Articles
• How a well-grounded minimal important difference can enhance transparency of labelling claims and improve interpretation of a patient reported outcome measure  Journal Articles
• How should clinicians interpret results reflecting the effect of an intervention on composite endpoints: Should I dump this lump?  Journal Articles
• How to Use a Noninferiority Trial  Journal Articles
• Impact of Optimal Medical Therapy With or Without Percutaneous Coronary Intervention on Long-Term Cardiovascular End Points in Patients With Stable Coronary Artery Disease (from the COURAGE Trial)  Journal Articles
• Impact of Routine 24 Hour Coronary Care Unit Stay in Stable Patients After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction  Journal Articles
• Improving outcome reporting in clinical trial reports and protocols: study protocol for the Instrument for reporting Planned Endpoints in Clinical Trials (InsPECT)  Journal Articles
• Influence of an independent review committee on assessment of response rate and progression-free survival in phase III clinical trials  Journal Articles
• Influence of censoring on conclusions of trials for women with metastatic breast cancer  Journal Articles
• Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease  Journal Articles
• Metastasis-Free Survival Is a Strong Surrogate of Overall Survival in Localized Prostate Cancer  Journal Articles
• Multicenter randomized controlled trial on Duration of Therapy for Thrombosis in Children and Young Adults (the Kids‐DOTT trial): pilot/feasibility phase findings  Journal Articles
• One Universal Common Endpoint in Mouse Models of Amyotrophic Lateral Sclerosis  Journal Articles
• Patient-reported outcomes in meta-analyses --Part 2: methods for improving interpretability for decision-makers  Journal Articles
• Problems of stopping trials early  Journal Articles
• Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials  Journal Articles
• Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial  Journal Articles
• Pros and Cons of Composite Endpoints in Anesthesia Trials  Journal Articles
• Randomized, double-blind, placebo-controlled trial of standardized ragweed sublingual-liquid immunotherapy for allergic rhinoconjunctivitis  Journal Articles
• Reasons for hospitalization and risk of mortality in patients with atrial fibrillation treated with dabigatran or warfarin in the Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY) trial  Journal Articles
• Recommended primary outcomes for clinical trials evaluating hemostatic blood products and agents in patients with bleeding: Proceedings of a National Heart Lung and Blood Institute and US Department of Defense Consensus Conference  Journal Articles
• Response to placebo in non-renal, non-neuropsychiatric systemic lupus erythematosus: a systematic review and pooled analysis  Journal Articles
• Safety and Efficacy of Ximelagatran: Meta-Analysis of the Controlled Randomized Trials for the Prophylaxis or Treatment of Venous Thromboembolism  Journal Articles
• Stopping rules employing response rates, time to progression, and early progressive disease for phase II oncology trials  Journal Articles
• Study Preregistration: Measuring What Matters: Development and Dissemination of a Core Outcome Set for Pediatric Anxiety Disorders Clinical Trials  Journal Articles
• Superiority of Fondaparinux Over Enoxaparin in Preventing Venous Thromboembolism in Major Orthopedic Surgery Using Different Efficacy End Points  Journal Articles
• Surrogate Markers in Clinical Studies: Problems Solved or Created?  Journal Articles
• Systematic evaluation of the methodology of randomized controlled trials of anticoagulation in patients with cancer  Journal Articles
• Systematic review and consensus definitions for standardised endpoints in perioperative medicine: postoperative cancer outcomes  Journal Articles
• Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis  Journal Articles
• Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes  Journal Articles
• Systematic review of basket trials, umbrella trials, and platform trials: a landscape analysis of master protocols  Journal Articles
• The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery  Journal Articles
• The Cost-Effectiveness of Percutaneous Coronary Intervention as a Function of Angina Severity in Patients With Stable Angina  Journal Articles
• The Gunslinger Effect: Why Are Movements Made Faster When Responding to Versus Initiating an Action?  Journal Articles
• The Intracerebral Haemorrhage Acutely Decreasing Arterial Pressure Trial: ICH ADAPT  Journal Articles
• The Irbesartan in Heart Failure With Preserved Systolic Function (I-PRESERVE) Trial: Rationale and Design  Journal Articles
• The National Lung Screening Trial: Overview and Study Design  Journal Articles
• The fate of endothelial function testing: rationale and design of the Firefighters And Their Endothelium (FATE) study.  Journal Articles
• The use of Fish Cells in Ecotoxicology: The Report and Recommendations of ECVAM Workshop 47^,  Journal Articles
• The use of surrogate endpoints in clinical trials: focus on clinical trials in cardiovascular diseases  Journal Articles
• Trends in the application of dynamic allocation methods in multi-arm cancer clinical trials  Journal Articles
• Use and Interpretation of Composite End Points in Orthopaedic Trials  Journal Articles
• Validation of the Rockall scoring system for outcomes from non-variceal upper gastrointestinal bleeding in a Canadian setting  Journal Articles
• Validity of composite end points in clinical trials  Journal Articles
• Water Chemistry Alters Gene Expression and Physiological End Points of Chronic Waterborne Copper Exposure in Zebrafish, Danio rerio  Journal Articles