Endpoint Determination
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Overview
subject area of
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A REVIEW OF POTENTIAL METHODS OF DETERMINING CRITICAL EFFECT SIZE FOR DESIGNING ENVIRONMENTAL MONITORING PROGRAMS Academic Article
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A Randomised, Double Blind, Placebo-controlled Study to Determine the Efficacy of Immune Modulation Therapy in the Treatment of Patients Suffering from Peripheral Arterial Occlusive Disease with Intermittent Claudication Academic Article
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A comparison of a new multinomial stopping rule with stopping rules of fleming and gehan in single arm phase II cancer clinical trials Academic Article
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A randomized phase 2 study of a HSP27 targeting antisense, apatorsen with prednisone versus prednisone alone, in patients with metastatic castration resistant prostate cancer Academic Article
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Accounting for treatment by center interaction in sample size determinations and the use of surrogate outcomes in the pessary for the prevention of preterm birth trial: a simulation study Academic Article
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Added value of health-related quality of life measurement in cancer clinical trials: the experience of the NCIC CTG Academic Article
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An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis Academic Article
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Assessment of clinically relevant bleeding as a surrogate outcome for major bleeding: validation by meta‐analysis of randomized controlled trials Academic Article
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Asymptomatic or “Silent” Atrial Fibrillation Academic Article
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Azimilide for the Treatment of Atrial Fibrillation, Atrial Flutter, and Paroxysmal Supraventricular Tachycardia: Results of a Randomized Trial and Insights on the Concordance of Symptoms and Recurrent Arrhythmias Academic Article
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Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? Reflections From aDiabetes CareEditors’ Expert Forum Academic Article
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Cinacalcet normalizes serum calcium in a double-blind randomized, placebo-controlled study in patients with primary hyperparathyroidism with contraindications to surgery Academic Article
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Clinical Models to Compare the Safety and Efficacy of Inhaled Corticosteroids in Patients with Asthma Academic Article
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Comparison of Outcomes of Phase II Studies and Subsequent Randomized Control Studies Using Identical Chemotherapeutic Regimens Conference Paper
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Consistency in the Analysis and Reporting of Primary End Points in Oncology Randomized Controlled Trials From Registration to Publication: A Systematic Review Academic Article
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Critical body residues, Michaelis–Menten analysis of bioaccumulation, lethality and behaviour as endpoints of waterborne Ni toxicity in two teleosts Academic Article
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Cytogenetic dose–response and adaptive response in cells of ungulate species exposed to ionizing radiation Academic Article
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Development of a Core Outcome Set for Studies on Cardiac Disease in Pregnancy (COSCarP): a study protocol Academic Article
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Development of a Core Outcome Set for Studies on Obesity in Pregnant Patients (COSSOPP): a study protocol Academic Article
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Effect of Reversal of Neuromuscular Blockade with Sugammadex versus Usual Care on Bleeding Risk in a Randomized Study of Surgical Patients Academic Article
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Effect of Rosiglitazone on Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease Academic Article
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Efficacy of pharmacological therapies in patients with IBS with diarrhoea or mixed stool pattern: systematic review and network meta-analysis Academic Article
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Endpoints in myelin-deficient (MD) rats. Academic Article
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Establishing the appropriate primary endpoint in haemophilia gene therapy pivotal studies Academic Article
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Evaluation of GERD Symptoms during Therapy. Part I Academic Article
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Evaluation of GERD Symptoms during Therapy. Part II Academic Article
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Evaluation of Short-Term Changes in Serum Creatinine Level as a Meaningful End Point in Randomized Clinical Trials Academic Article
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Evolution of Clinical Trials Registries Academic Article
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FDA ovarian cancer clinical trial endpoints workshop: A Society of Gynecologic Oncology White Paper Academic Article
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Fluid Lavage of Open Wounds (FLOW): design and rationale for a large, multicenter collaborative 2 × 3 factorial trial of irrigating pressures and solutions in patients with open fractures Academic Article
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GFR Decline as an Alternative End Point in Clinical Trials to Prevent ESRD: Are We Increasing Treatment Uncertainty for the Sake of Feasibility? Academic Article
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GRADE Leitlinien: 13. Erstellen von Summary-of-Findings-Tabellen und Evidenzprofilen – kontinuierliche Endpunkte Academic Article
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GRADE Leitlinien: 7. Einschätzung der Qualität der Evidenz – Inkonsistenz Academic Article
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GRADE Leitlinien: 8. Einschätzung der Qualität der Evidenz – Indirektheit Academic Article
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GRADE guidelines 27: how to calculate absolute effects for time-to-event outcomes in summary of findings tables and Evidence Profiles Academic Article
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GRADE-Leitlinien: 1. Einführung – GRADE-Evidenzprofile und Summary-of-Findings-Tabellen Academic Article
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GRADE-Leitlinien: 12. Erstellen von „Summary-of-Findings“-Tabellen – Dichotome Endpunkte Academic Article
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GRADE-Leitlinien: 2. Formulierung der Fragestellung und Entscheidung über wichtige Endpunkte Academic Article
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GRADE-Leitlinien: 4. Bewertung der Qualität der Evidenz – Studienlimitationen (Risiko für Bias) Academic Article
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Global haemostasis and point of care testing Academic Article
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Guidelines for fracture healing assessments in clinical trials. Part I: Definitions and endpoint committees Academic Article
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Guidelines for fracture healing assessments in clinical trials. Part II: Electronic data capture and image management systems—Global Adjudicator™ system Academic Article
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How a well-grounded minimal important difference can enhance transparency of labelling claims and improve interpretation of a patient reported outcome measure Academic Article
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How should clinicians interpret results reflecting the effect of an intervention on composite endpoints: Should I dump this lump? Academic Article
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How to Use a Noninferiority Trial Academic Article
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Impact of Optimal Medical Therapy With or Without Percutaneous Coronary Intervention on Long-Term Cardiovascular End Points in Patients With Stable Coronary Artery Disease (from the COURAGE Trial) Academic Article
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Impact of Routine 24 Hour Coronary Care Unit Stay in Stable Patients After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Academic Article
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Improving outcome reporting in clinical trial reports and protocols: study protocol for the Instrument for reporting Planned Endpoints in Clinical Trials (InsPECT) Academic Article
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Influence of an independent review committee on assessment of response rate and progression-free survival in phase III clinical trials Academic Article
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Influence of censoring on conclusions of trials for women with metastatic breast cancer Academic Article
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Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease Academic Article
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Metastasis-Free Survival Is a Strong Surrogate of Overall Survival in Localized Prostate Cancer Academic Article
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Multicenter randomized controlled trial on Duration of Therapy for Thrombosis in Children and Young Adults (the Kids‐DOTT trial): pilot/feasibility phase findings Academic Article
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One Universal Common Endpoint in Mouse Models of Amyotrophic Lateral Sclerosis Academic Article
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Patient-reported outcomes in meta-analyses --Part 2: methods for improving interpretability for decision-makers Academic Article
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Problems of stopping trials early Academic Article
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Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials Academic Article
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Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial Academic Article
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Proposal for Standardized Definitions for Efficacy End Points in Adjuvant Breast Cancer Trials: The STEEP System Academic Article
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Pros and Cons of Composite Endpoints in Anesthesia Trials Academic Article
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Randomized, double-blind, placebo-controlled trial of standardized ragweed sublingual-liquid immunotherapy for allergic rhinoconjunctivitis Academic Article
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Reasons for hospitalization and risk of mortality in patients with atrial fibrillation treated with dabigatran or warfarin in the Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY) trial Academic Article
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Recommended primary outcomes for clinical trials evaluating hemostatic blood products and agents in patients with bleeding: Proceedings of a National Heart Lung and Blood Institute and US Department of Defense Consensus Conference Academic Article
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Response to placebo in non-renal, non-neuropsychiatric systemic lupus erythematosus: a systematic review and pooled analysis Academic Article
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Safety and Efficacy of Ximelagatran: Meta-Analysis of the Controlled Randomized Trials for the Prophylaxis or Treatment of Venous Thromboembolism Academic Article
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Standards of Proof, Standards of Practice, and Proof of Standards: A Tale of Two Trials Academic Article
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Stopping rules employing response rates, time to progression, and early progressive disease for phase II oncology trials Academic Article
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Study Preregistration: Measuring What Matters: Development and Dissemination of a Core Outcome Set for Pediatric Anxiety Disorders Clinical Trials Academic Article
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Superiority of Fondaparinux Over Enoxaparin in Preventing Venous Thromboembolism in Major Orthopedic Surgery Using Different Efficacy End Points Academic Article
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Surrogate Markers in Clinical Studies: Problems Solved or Created? Academic Article
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Systematic evaluation of the methodology of randomized controlled trials of anticoagulation in patients with cancer Academic Article
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Systematic review and consensus definitions for standardised endpoints in perioperative medicine: postoperative cancer outcomes Academic Article
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Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis Academic Article
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Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes Academic Article
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Systematic review of basket trials, umbrella trials, and platform trials: a landscape analysis of master protocols Academic Article
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The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery Academic Article
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The Cost-Effectiveness of Percutaneous Coronary Intervention as a Function of Angina Severity in Patients With Stable Angina Academic Article
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The Gunslinger Effect: Why Are Movements Made Faster When Responding to Versus Initiating an Action? Academic Article
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The Intracerebral Haemorrhage Acutely Decreasing Arterial Pressure Trial: ICH ADAPT Academic Article
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The Irbesartan in Heart Failure With Preserved Systolic Function (I-PRESERVE) Trial: Rationale and Design Academic Article
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The analysis of terminal endpoint events in stepped wedge designs Academic Article
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The fate of endothelial function testing: rationale and design of the Firefighters And Their Endothelium (FATE) study. Academic Article
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The use of Fish Cells in Ecotoxicology: The Report and Recommendations of ECVAM Workshop 47, Academic Article
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The use of surrogate endpoints in clinical trials: focus on clinical trials in cardiovascular diseases Academic Article
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Trends in the application of dynamic allocation methods in multi-arm cancer clinical trials Academic Article
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Use and Interpretation of Composite End Points in Orthopaedic Trials Academic Article
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Validation of the Rockall scoring system for outcomes from non-variceal upper gastrointestinal bleeding in a Canadian setting Academic Article
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Validity of composite end points in clinical trials Academic Article
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Water Chemistry Alters Gene Expression and Physiological End Points of Chronic Waterborne Copper Exposure in Zebrafish, Danio rerio Academic Article
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Women with Pain due to Osteoarthritis: The Efficacy and Safety of a Once-Daily Formulation of Tramadol Academic Article