Clinical Trials, Phase II as Topic Concept

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A Canadian phase II study evaluating the efficacy of rituximab in the management of patients with relapsed/refractory thrombotic thrombocytopenic purpura Conference Paper
A Phase I Study of OGX-011, a 2′-Methoxyethyl Phosphorothioate Antisense to Clusterin, in Combination with Docetaxel in Patients with Advanced Cancer Academic Article
A Replacement for Warfarin Academic Article
A comparison of a new multinomial stopping rule with stopping rules of fleming and gehan in single arm phase II cancer clinical trials Academic Article
A multidisciplinary “think tank”: the top 10 clinical trial opportunities in transfusion medicine from the National Heart, Lung, and Blood Institute-sponsored 2009 state-of-the-science symposium Academic Article
A semimechanistic-physiologic population pharmacokinetic/pharmacodynamic model for neutropenia following pemetrexed therapy Academic Article
Adjuvant oncolytic virotherapy for personalized anti-cancer vaccination Academic Article
Advances in Antithrombotic Therapy: Novel Agents Academic Article
Andexanet alfa for the treatment of hemorrhage Academic Article
Antithrombotic therapy for stroke prevention in atrial fibrillation and mechanical heart valves Academic Article
Apixaban in Acute Coronary Syndromes Academic Article
CCI-779 Wyeth. Academic Article
Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? Reflections From aDiabetes CareEditors’ Expert Forum Academic Article
Challenges in the conduct and interpretation of phase II (pilot) randomized trials Academic Article
Clinical application of a semimechanistic-physiologic population PK/PD model for neutropenia following pemetrexed therapy Academic Article
Clinical cooperative trials of the National Cancer Institute of Canada Clinical Trials Group Breast Cancer Site Group. Academic Article
Clinical trial opportunities in hemostasis and thrombosis: NHBLI State-of-the-science symposium Academic Article
Colchicine pre-treatment and post-treatment does not worsen bleeding or functional outcome after collagenase-induced intracerebral hemorrhage Academic Article
Combination 13-cis-retinoic acid and interferon alpha-2a in the therapy of solid tumors. Academic Article
Comparison of Outcomes of Phase II Studies and Subsequent Randomized Control Studies Using Identical Chemotherapeutic Regimens Conference Paper
Complete Response as an Intermediate End Point in Patients Receiving Salvage Systemic Therapy for Urothelial Carcinoma Academic Article
Correlation of single arm versus randomised phase 2 oncology trial characteristics with phase 3 outcome Academic Article
Current Incidence and Outcomes of Gastrointestinal Mesenchymal Tumors Including Gastrointestinal Stromal Tumors Academic Article
DNA methyltransferase inhibitors—state of the art Academic Article
Dabigatran Etexilate: Future Directions in Anticoagulant Treatment Academic Article
Development of adapted RECIST criteria to assess response in lymphoma and their comparison to the International Workshop Criteria Academic Article
Direct-acting antiviral therapies for hepatitis C genotype 1 infection: a multiple treatment comparison meta-analysis Academic Article
Drug evaluation: E-5564. Academic Article
Efficacy and safety of rolapitant for prevention of chemotherapy-induced nausea and vomiting over multiple cycles of moderately or highly emetogenic chemotherapy Academic Article
Evaluation of Adverse Events Experienced by Older Patients Participating in Studies of Molecularly Targeted Agents Alone or in Combination Academic Article
Five-Factor Prognostic Model for Survival of Post-Platinum Patients with Metastatic Urothelial Carcinoma Receiving PD-L1 Inhibitors Academic Article
Fondaparinux, the first selective factor Xa inhibitor Academic Article
Heterogeneity among lists of cautioned or prohibited drugs in protocols of early-phase oncology trials Academic Article
Human Gene Marker/Therapy Clincal Protocols (Complete Updated Listings) Academic Article
Impact of Response to Prior Chemotherapy in Patients With Advanced Urothelial Carcinoma Receiving Second-Line Therapy: Implications for Trial Design Academic Article
Impact of the Number of Prior Lines of Therapy and Prior Perioperative Chemotherapy in Patients Receiving Salvage Therapy for Advanced Urothelial Carcinoma: Implications for Trial Design Academic Article
Implementation of Timeline Reforms Speeds Initiation of National Cancer Institute-Sponsored Trials Academic Article
Improved 5-Factor Prognostic Classification of Patients Receiving Salvage Systemic Therapy for Advanced Urothelial Carcinoma Academic Article
Incidence of delayed venous thromboembolic events in patients undergoing abdominal and pelvic surgery for cancer: a systematic review and meta‐analysis Academic Article
Incomplete Cross-Resistance Between Taxanes for Advanced Urothelial Carcinoma: Implications for Clinical Practice and Trial Design Academic Article
Integrated safety and efficacy analysis of once-daily fluticasone furoate for the treatment of asthma Academic Article
Investigating the appropriateness of different concordance measures in a time‐to‐event setting Academic Article
Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial Academic Article
Magnitude of benefit of the addition of bevacizumab to first-line chemotherapy for metastatic colorectal cancer: meta-analysis of randomized clinical trials Conference Paper
Management of Patients with Acute Coronary Syndromes Academic Article
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group Report Academic Article
New Anticoagulant Drugs Academic Article
New Anticoagulants for Treatment of Venous Thromboembolism Academic Article
New Antithrombotic Drugs Academic Article
Nomograms to Predict Serious Adverse Events in Phase II Clinical Trials of Molecularly Targeted Agents Academic Article
Objective Responses in Patients with Malignant Melanoma or Renal Cell Cancer in Early Clinical Studies Do Not Predict Regulatory Approval Academic Article
Optimizing vaccine-induced CD8⁺T-cell immunity: focus on recombinant adenovirus vectors Academic Article
Otamixaban in acute coronary syndromes Academic Article
Our Choice: study protocol for a randomized controlled trial for optimal implementation of psoriasis treatment by the integration of Chinese and western medicine Academic Article
Overstated Conclusions of a Pooled Analysis of Bevacizumab in Colon Cancer Academic Article
Overview of the New Oral Anticoagulants Academic Article
Panorama From the Oncolytic Virotherapy Summit Academic Article
Patient Eligibility and Trial Design for the Salvage Therapy of Advanced Urothelial Carcinoma Academic Article
Pentasaccharide Org31540/SR90107A clinical trials update: Lessons for practice Academic Article
Phase I/II trials of 186Re-HEDP in metastatic castration-resistant prostate cancer: post-hoc analysis of the impact of administered activity and dosimetry on survival Academic Article
Phase II Stopping Rules That Employ Response Rates and Early Progression Academic Article
Phosphoinositide 3-kinase inhibitors in advanced breast cancer: A systematic review and meta-analysis Academic Article
Posttreatment prognostic nomogram for patients with metastatic urothelial cancer completing first-line cisplatin-based chemotherapy Academic Article
Preclinical pharmacokinetics, biodistribution, radiation dosimetry and acute toxicity studies required for regulatory approval of a Clinical Trial Application for a Phase I/II clinical trial of 111In-BzDTPA-pertuzumab Academic Article
Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism Academic Article
Proton Pump Inhibitors and Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma Academic Article
Proton pump inhibitors: the beginning of the end or the end of the beginning? Academic Article
Quantitative evaluation of single-arm versus randomized phase II cancer clinical trials Academic Article
Randomized Phase II Trials: Inevitable or Inadvisable? Academic Article
Randomized, controlled clinical trials in sepsis: Has methodological quality improved over time? Academic Article
Remote ischemic conditioning in necrotizing enterocolitis: study protocol of a multi-center phase II feasibility randomized controlled trial Academic Article
Response of Primary Renal Cell Carcinoma to Systemic Therapy Academic Article
Rolapitant for the treatment of chemotherapy-induced nausea and vomiting: a review of the clinical evidence Academic Article
Safety Outcomes in Meta-analyses of Phase 2 vs Phase 3 Randomized Trials Academic Article
Seeking informed consent to cancer clinical trials: Academic Article
Single-agent Taxane Versus Taxane-containing Combination Chemotherapy as Salvage Therapy for Advanced Urothelial Carcinoma. Academic Article
Stopping rules employing response rates, time to progression, and early progressive disease for phase II oncology trials Academic Article
Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy Academic Article
Systematic Chemotherapy for Inoperable, Locally Advanced, Recurrent, or Metastatic Uterine Leiomyosarcoma: A Systematic Review Academic Article
Systemic adjuvant therapy for adult patients at high risk for recurrent melanoma: A systematic review Academic Article
Systemic therapy for advanced uterine sarcoma: A systematic review of the literature Academic Article
The Role of Gemcitabine in the Treatment of Cholangiocarcinoma and Gallbladder Cancer: A Systematic Review Academic Article
The use of chemotherapy in patients with advanced malignant pleural mesothelioma: a systematic review and practice guideline. Academic Article
Treatment Strategies in Elderly Patients with Aggressive Histology Lymphoma Academic Article
Treatment of Multiple Myeloma: ASCO and CCO Joint Clinical Practice Guideline Academic Article
[¹⁸F]DCFPyL PET-MRI/CT for unveiling a molecularly defined oligorecurrent prostate cancer state amenable for curative-intent ablative therapy: study protocol for a phase II trial Academic Article