Clinical Trials, Phase II as Topic Concept

subject area of

• A Canadian phase II study evaluating the efficacy of rituximab in the management of patients with relapsed/refractory thrombotic thrombocytopenic purpura  Conferences
• A Phase I Study of OGX-011, a 2′-Methoxyethyl Phosphorothioate Antisense to Clusterin, in Combination with Docetaxel in Patients with Advanced Cancer  Journal Articles
• A Replacement for Warfarin  Journal Articles
• A comparison of a new multinomial stopping rule with stopping rules of fleming and gehan in single arm phase II cancer clinical trials  Journal Articles
• A phase 2 study of stereotactic body radiation therapy for squamous cell carcinoma of the head and neck (SHINE): a single arm clinical trial protocol  Journal Articles
• A semimechanistic-physiologic population pharmacokinetic/pharmacodynamic model for neutropenia following pemetrexed therapy  Journal Articles
• Adjuvant oncolytic virotherapy for personalized anti-cancer vaccination  Journal Articles
• Advances in Antithrombotic Therapy: Novel Agents  Journal Articles
• An estimate of the cost of conducting phase II trials in lung cancer  Journal Articles
• Andexanet alfa for the treatment of hemorrhage  Journal Articles
• Antithrombotic therapy for stroke prevention in atrial fibrillation and mechanical heart valves  Journal Articles
• Apixaban in Acute Coronary Syndromes  Journal Articles
• CCI-779 Wyeth.  Journal Articles
• Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? Reflections From aDiabetes CareEditors’ Expert Forum  Journal Articles
• Challenges in the conduct and interpretation of phase II (pilot) randomized trials  Journal Articles
• Clinical and Molecular Studies of the Effect of Imatinib on Advanced Aggressive Fibromatosis (desmoid tumor)  Journal Articles
• Clinical application of a semimechanistic-physiologic population PK/PD model for neutropenia following pemetrexed therapy  Journal Articles
• Clinical trial design in metastatic breast cancer: a commentary.  Journal Articles
• Colchicine pre-treatment and post-treatment does not worsen bleeding or functional outcome after collagenase-induced intracerebral hemorrhage  Journal Articles
• Combination 13-cis-retinoic acid and interferon alpha-2a in the therapy of solid tumors.  Journal Articles
• Comparison of Outcomes of Phase II Studies and Subsequent Randomized Control Studies Using Identical Chemotherapeutic Regimens  Conferences
• Complete Response as an Intermediate End Point in Patients Receiving Salvage Systemic Therapy for Urothelial Carcinoma  Journal Articles
• Correlation of single arm versus randomised phase 2 oncology trial characteristics with phase 3 outcome  Journal Articles
• Current Incidence and Outcomes of Gastrointestinal Mesenchymal Tumors Including Gastrointestinal Stromal Tumors  Journal Articles
• DNA methyltransferase inhibitors—state of the art  Journal Articles
• Dabigatran Etexilate: Future Directions in Anticoagulant Treatment  Journal Articles
• Development of adapted RECIST criteria to assess response in lymphoma and their comparison to the International Workshop Criteria  Journal Articles
• Direct-acting antiviral therapies for hepatitis C genotype 1 infection: a multiple treatment comparison meta-analysis  Journal Articles
• Drug evaluation: E-5564.  Journal Articles
• Efficacy and safety of rolapitant for prevention of chemotherapy-induced nausea and vomiting over multiple cycles of moderately or highly emetogenic chemotherapy  Journal Articles
• Evaluation of Adverse Events Experienced by Older Patients Participating in Studies of Molecularly Targeted Agents Alone or in Combination  Journal Articles
• Five-Factor Prognostic Model for Survival of Post-Platinum Patients with Metastatic Urothelial Carcinoma Receiving PD-L1 Inhibitors  Journal Articles
• Fondaparinux, the first selective factor Xa inhibitor  Journal Articles
• Heterogeneity among lists of cautioned or prohibited drugs in protocols of early-phase oncology trials  Journal Articles
• Human Gene Marker/Therapy Clincal Protocols (Complete Updated Listings)  Journal Articles
• Ifosfamide, cisplatin, and etoposide (ICE) in the treatment of advanced non-small cell lung cancer.  Journal Articles
• Impact of Response to Prior Chemotherapy in Patients With Advanced Urothelial Carcinoma Receiving Second-Line Therapy: Implications for Trial Design  Journal Articles
• Impact of the Number of Prior Lines of Therapy and Prior Perioperative Chemotherapy in Patients Receiving Salvage Therapy for Advanced Urothelial Carcinoma: Implications for Trial Design  Journal Articles
• Implementation of Timeline Reforms Speeds Initiation of National Cancer Institute-Sponsored Trials  Journal Articles
• Improved 5-Factor Prognostic Classification of Patients Receiving Salvage Systemic Therapy for Advanced Urothelial Carcinoma  Journal Articles
• Incidence of delayed venous thromboembolic events in patients undergoing abdominal and pelvic surgery for cancer: a systematic review and meta‐analysis  Journal Articles
• Incomplete Cross-Resistance Between Taxanes for Advanced Urothelial Carcinoma: Implications for Clinical Practice and Trial Design  Journal Articles
• Integrated safety and efficacy analysis of once-daily fluticasone furoate for the treatment of asthma  Journal Articles
• Investigating the appropriateness of different concordance measures in a time‐to‐event setting  Journal Articles
• Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial  Journal Articles
• Magnitude of benefit of the addition of bevacizumab to first-line chemotherapy for metastatic colorectal cancer: meta-analysis of randomized clinical trials  Conferences
• Management of Patients with Acute Coronary Syndromes  Journal Articles
• National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group Report  Journal Articles
• New Anticoagulant Drugs  Journal Articles
• New Anticoagulants for Treatment of Venous Thromboembolism  Journal Articles
• New Antithrombotic Drugs  Journal Articles
• Nomograms to Predict Serious Adverse Events in Phase II Clinical Trials of Molecularly Targeted Agents  Journal Articles
• Objective Responses in Patients with Malignant Melanoma or Renal Cell Cancer in Early Clinical Studies Do Not Predict Regulatory Approval  Journal Articles
• Optimizing vaccine-induced CD8⁺T-cell immunity: focus on recombinant adenovirus vectors  Journal Articles
• Otamixaban in acute coronary syndromes  Journal Articles
• Our Choice: study protocol for a randomized controlled trial for optimal implementation of psoriasis treatment by the integration of Chinese and western medicine  Journal Articles
• Overstated Conclusions of a Pooled Analysis of Bevacizumab in Colon Cancer  Journal Articles
• Overview of the New Oral Anticoagulants  Journal Articles
• Panorama From the Oncolytic Virotherapy Summit  Journal Articles
• Patient Eligibility and Trial Design for the Salvage Therapy of Advanced Urothelial Carcinoma  Journal Articles
• Pentasaccharide Org31540/SR90107A clinical trials update: Lessons for practice  Journal Articles
• Phase 2 Vitamin C Sepsis Trials: Another Brick in the (Evidence) Wall?*  Journal Articles
• Phase I/II trials of 186Re-HEDP in metastatic castration-resistant prostate cancer: post-hoc analysis of the impact of administered activity and dosimetry on survival  Journal Articles
• Phase II Stopping Rules That Employ Response Rates and Early Progression  Journal Articles
• Posttreatment prognostic nomogram for patients with metastatic urothelial cancer completing first-line cisplatin-based chemotherapy  Journal Articles
• Preclinical pharmacokinetics, biodistribution, radiation dosimetry and acute toxicity studies required for regulatory approval of a Clinical Trial Application for a Phase I/II clinical trial of 111In-BzDTPA-pertuzumab  Journal Articles
• Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism  Journal Articles
• Proton Pump Inhibitors and Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma  Journal Articles
• Proton pump inhibitors: the beginning of the end or the end of the beginning?  Journal Articles
• Quantitative evaluation of single-arm versus randomized phase II cancer clinical trials  Journal Articles
• Randomized Phase II Trials: Inevitable or Inadvisable?  Journal Articles
• Randomized, controlled clinical trials in sepsis: Has methodological quality improved over time?  Journal Articles
• Remote ischemic conditioning in necrotizing enterocolitis: study protocol of a multi-center phase II feasibility randomized controlled trial  Journal Articles
• Response of Primary Renal Cell Carcinoma to Systemic Therapy  Journal Articles
• Rolapitant for the Treatment of Chemotherapy-Induced Nausea and Vomiting: A Review of the Clinical Evidence  Journal Articles
• Safety Outcomes in Meta-analyses of Phase 2 vs Phase 3 Randomized Trials  Journal Articles
• Seeking informed consent to cancer clinical trials:  Journal Articles
• Single-agent Taxane Versus Taxane-containing Combination Chemotherapy as Salvage Therapy for Advanced Urothelial Carcinoma  Journal Articles
• Single-agent Taxane Versus Taxane-containing Combination Chemotherapy as Salvage Therapy for Advanced Urothelial Carcinoma.  Journal Articles
• Stopping rules employing response rates, time to progression, and early progressive disease for phase II oncology trials  Journal Articles
• Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microglobulin in subjects at high risk for acute kidney injury following open-chest cardiac surgery (AKITA trial)  Journal Articles
• Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy  Journal Articles
• Systematic Chemotherapy for Inoperable, Locally Advanced, Recurrent, or Metastatic Uterine Leiomyosarcoma: A Systematic Review  Journal Articles
• Systemic adjuvant therapy for adult patients at high risk for recurrent melanoma: A systematic review  Journal Articles
• Systemic therapy for advanced uterine sarcoma: A systematic review of the literature  Journal Articles
• Systemic therapy in the curative treatment of head and neck squamous cell cancer: A systematic review  Journal Articles
• The Role of Gemcitabine in the Treatment of Cholangiocarcinoma and Gallbladder Cancer: A Systematic Review  Journal Articles
• The Use of Chemotherapy in Patients with Advanced Malignant Pleural Mesothelioma: A Systematic Review and Practice Guideline  Journal Articles
• The use of gemcitabine in non-small-cell lung cancer. Provincial Lung Cancer Disease Site Group. Provincial Systemic Treatment Disease Site Group.  Journal Articles
• Treatment Strategies in Elderly Patients with Aggressive Histology Lymphoma  Journal Articles
• Treatment of Multiple Myeloma: ASCO and CCO Joint Clinical Practice Guideline  Journal Articles
• Treatment of idiopathic pulmonary fibrosis: an update on emerging drugs in phase II & III clinical trials  Journal Articles
• [¹⁸F]DCFPyL PET-MRI/CT for unveiling a molecularly defined oligorecurrent prostate cancer state amenable for curative-intent ablative therapy: study protocol for a phase II trial  Journal Articles