Journal article
Characterization of a catalytically efficient acidic RNA-cleaving deoxyribozyme
Abstract
We previously demonstrated--through the isolation of RNA-cleaving deoxyribozymes by in vitro selection that are catalytically active in highly acidic solutions--that DNA, despite its chemical simplicity, could perform catalysis under challenging chemical conditions [Liu,Z., Mei,S.H., Brennan,J.D. and Li,Y. (2003) J. Am. Chem. Soc. 125, 7539-7545]. One remarkable DNA molecule therefrom is pH4DZ1, a self-cleaving deoxyribozyme that exhibits a …
Authors
Kandadai SA; Li Y
Journal
Nucleic Acids Research, Vol. 33, No. 22, pp. 7164–7175
Publisher
Oxford University Press (OUP)
Publication Date
December 9, 2005
DOI
10.1093/nar/gki1013
ISSN
0305-1048