Ian Daniel Spenser - McMaster Experts

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Faculty of Science, McMaster University
Professor Emeritus, Chemistry & Chemical Biology, Faculty of Science

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journal articles
- 3-Amino-1-hydroxyacetone. Canadian Journal of Chemistry. 82:579-582. 2004
- Biosynthesis of Vitamin B₁ in Yeast. Derivation of the Pyrimidine Unit from Pyridoxine and Histidine. Intermediacy of Urocanic Acid. Journal of the American Chemical Society. 125:13094-13105. 2003
- Biosynthesis of Vitamin B₆ in Yeast. Incorporation Pattern of Trioses.. ChemInform. 34:no-no. 2003
- Biosynthesis of Vitamin B₆ in Yeast. Incorporation Pattern of Trioses. Journal of Organic Chemistry. 68:3486-3493. 2003
- Deuterium-labeled 2′-Hydroxypyridoxol. Synlett. 2003:1344-1348. 2003
- 2‘-Hydroxypyridoxol, a Biosynthetic Precursor of Vitamins B₆ and B₁ in Yeast. Journal of the American Chemical Society. 124:4542-4543. 2002
- Biosynthesis of Vitamin B₆ in Yeast: Incorporation Pattern of Glucose. Journal of the American Chemical Society. 123:11353-11359. 2001
- Incorporation of¹³C glucose into nicotinamide inE. coliand inS. cerevisiae. Canadian Journal of Chemistry. 79:418-425. 2001
- An NMR study of the Lythraceae alkaloids. Magnetic Resonance in Chemistry. 38:707-718. 2000
- Biosynthesis of Vitamin B₆: Origin of the Oxygen Atoms of Pyridoxol Phosphate. Journal of the American Chemical Society. 122:4213-4214. 2000
- Biosynthesis of Vitamin B₆: Enzymatic Conversion of 1-Deoxy-d-xylulose-5-phosphate to Pyridoxol Phosphate. Journal of the American Chemical Society. 121:7722-7723. 1999
- Comparative Biogenetic Anatomy of Vitamin B₁: A ¹³C NMR Investigation of the Biosynthesis of Thiamin in Escherichia coli and in Saccharomyces cerevisiae. Journal of the American Chemical Society. 120:3581-3589. 1998
- Biosynthesis of Vitamin B₆: The Oxidation of 4-(Phosphohydroxy)-l-threonine by PdxA. Journal of the American Chemical Society. 120:1936-1937. 1998
- ChemInform Abstract: 5‐Hydroxypentane‐2,3‐dione and 3‐Amino‐1‐hydroxypropan‐2‐one, Putative Precursors of Vitamin B6.. ChemInform. 28:no-no. 1997
- ChemInform Abstract: Biosynthesis of Vitamin B1 (Thiamine): An Instance of Biochemical Diversity. ChemInform. 28:no-no. 1997
- 5-Hydroxypentane-2,3-dione and 3-amino-1-hydroxypropan-2-one, putative precursors of vitamin B₆. Canadian Journal of Chemistry. 75:942-948. 1997
- Die Biosynthese von Vitamin B₁ (Thiamin): ein Beispiel für biochemische Vielfalt. Angewandte Chemie International Edition. 109:1096-1111. 1997
- Biosynthesis of Vitamin B₁ (Thiamin): An Instance of Biochemical Diversity. Angewandte Chemie International Edition. 36:1032-1046. 1997
- The Biogenetic Anatomy of Vitamin B6. Journal of Biological Chemistry. 271:30426-30435. 1996
- ChemInform Abstract: Biosynthesis of Vitamins B1 and B6 in Escherichia coli: Concurrent Incorporation of 1‐Deoxy‐D‐xylulose into Thiamin (B1) and Pyridoxol ( B6).. ChemInform. 27:no-no. 1996
- Deceptively simple NMR spectra of contiguously C-13-enriched compounds. Croatica Chemica Acta. 69:681-688. 1996
- A Classical Paradigm of Alkaloid Biogenesis Revisited: Acetonedicarboxylic Acid as a Biosynthetic Precursor of Lycopodine. Journal of the American Chemical Society. 118:1799-1800. 1996
- Biosynthesis of vitamins B1 and B6 in Escherichia coli: concurrent incorporation of 1-deoxy-D-xylulose into thiamin (B1) and pyridoxol (B6). Chemical Communications. 0:1187-1187. 1996
- [2,3-13C2]-4-Hydroxy-L-threonine. Journal of Organic Chemistry. 60:6937-6940. 1995
- 1-Deoxy-D-xylulose. Canadian Journal of Chemistry. 73:1329-1337. 1995
- Biosynthesis of Vitamin B6: Origin of Pyridoxine by the Union of Two Acyclic Precursors, 1-Deoxy-D-xylulose and 4-Hydroxy-L-threonine. Journal of the American Chemical Society. 117:1661-1662. 1995
- 4-Hydroxy-L-threonine, a committed precursor of pyridoxol (vitamin B6). Chemical Communications. 0:1339-1339. 1995
- The biosynthesis of pyridoxine. Natural product reports (Print). 12:555-555. 1995
- Biosynthetic Route to the Ephedra Alkaloids. Journal of the American Chemical Society. 116:6195-6200. 1994
- Biosynthesis of Anosmine: Incorporation of the Intact Six-Carbon Chain of Lysine and of Pipecolic Acid. Journal of natural products. 56:1281-1287. 1993
- Biosynthesis of lycopodine: incorporation of acetate via an intermediate with C2v symmetry. Journal of the American Chemical Society. 115:3020-3021. 1993
- Biosynthesis of the Ephedra alkaloids: evolution of the C6-C3 skeleton. Journal of the American Chemical Society. 115:2052-2054. 1993
- Growth response to 4‐hydroxy‐l‐threonine of Escherichia coli mutants blocked in vitamin B₆ biosynthesis. FEBS Letters. 318:125-128. 1993
- ChemInform Abstract: Biosynthesis of 6β‐Hydroxytropine (I) in Datura stramonium: Nonregiospecific Incorporation of (1,2‐13C2)Acetate.. ChemInform. 23:no-no. 1992
- Biosynthesis of 6.beta.-hydroxytropine in Datura stramonium: nonregiospecific incorporation of [1,2-13C2]acetate. Journal of the American Chemical Society. 114:5472-5473. 1992
- Biosynthesis of anosmine, an imidazole alkaloid of the orchid Dendrobium parishii. Chemical Communications. 0:494-494. 1991
- Biosynthesis of N-methylpelletierine: vindication of a classical biogenetic concept. Journal of the American Chemical Society. 112:6360-6363. 1990
- The biosynthesis of ephedrine. Canadian Journal of Chemistry. 67:998-1009. 1989
- Biosynthesis of vitamin B6: incorporation of D-1-deoxyxylulose. Journal of the American Chemical Society. 111:1916-1917. 1989
- Biosynthesis of the lupine alkaloids. II. Sparteine and lupanine. Canadian Journal of Chemistry. 66:1734-1748. 1988
- Biosynthesis of ephedrine. Journal of the American Chemical Society. 110:3714-3715. 1988
- Carbon-13 NMR spectroscopy as a biosynthetic probe. The biosynthesis of purines in yeast. Journal of the American Chemical Society. 109:4698-4702. 1987
- The regiochemistry and stereochemistry of the biosynthesis of vitamin B6 from triose units.. Journal of Biological Chemistry. 262:7463-7471. 1987
- Biosynthesis of lupanine: incorporation of [3,3-²H₂]cadaverine. Canadian Journal of Chemistry. 65:170-174. 1987
- Correction. Thiamin Biosynthesis in Saccharomyces cerevisiae: Origin of the Pyrimidine Unit. Journal of the American Chemical Society. 108:3863-3863. 1986
- ChemInform Abstract: Thiamin Biosynthesis in Saccharomyces cerevisiae: Origin of the Pyrimidine Unit. ChemInform. 17:no-no. 1986
- Biosynthesis of vitamin B6. Direct evidence for the mode of incorporation of C3-units derived from D-[U-13C6]glucose. Chemical Communications. 0:612-612. 1986
- Thiamin biosynthesis in Saccharomyces cerevisiae: origin of the pyrimidine unit. Journal of the American Chemical Society. 108:146-158. 1986
- Biosynthesis of the lupine alkaloids. I. Lupinine. Canadian Journal of Chemistry. 63:2707-2718. 1985
- ChemInform Abstract: DEUTERON NMR SPECTROSCOPY AS A PROBE OF THE STEREOCHEMISTRY OF BIOSYNTHETIC REACTIONS: THE BIOSYNTHESIS OF LUPANINE AND SPARTEINE. ChemInform. 16:no-no. 1985
- Lactams of sparteine. Canadian Journal of Chemistry. 63:716-719. 1985
- Stereochemical aspects of the biosynthetic routes leading to the pyrrolizidine and the quinolizidine alkaloids. Pure and Applied Chemistry. 57:453-470. 1985
- Deuteron NMR spectroscopy as a probe of the stereochemistry of biosynthetic reactions: the biosynthesis of lupanine and sparteine. Journal of the American Chemical Society. 106:7925-7927. 1984
- ChemInform Abstract: BIOSYNTHESIS OF VITAMIN B6: INCORPORATION OF A CARBON‐NITROGEN UNIT DERIVED FROM GLYCINE. ChemInform. 15:no-no. 1984
- ChemInform Abstract: DEUTERON NMR SPECTROSCOPY AS A PROBE OF THE STEREOCHEMISTRY OF BIOSYNTHETIC REACTIONS: THE BIOSYNTHESIS OF LUPININE. ChemInform. 15:no-no. 1984
- Biosynthesis of vitamin B6: incorporation of a carbon-nitrogen unit derived from glycine. Journal of the American Chemical Society. 106:1840-1841. 1984
- Deuteron NMR spectroscopy as a probe of the stereochemistry of biosynthetic reactions: the biosynthesis of lupinine. Journal of the American Chemical Society. 106:1441-1442. 1984
- Deuterium nuclear magnetic resonance spectroscopy as a probe of the stereochemistry of biosynthetic reactions: the biosynthesis of retronecine. Journal of the American Chemical Society. 105:7401-7404. 1983
- 2H NMR spectroscopy as a probe of the stereochemistry of enzymic reactions at prochiral centres. Tetrahedron. 39:3549-3568. 1983
- A 13C n.m.r. study of the biosynthesis of lupinine and sparteine. Chemical Communications. 0:1509-1509. 1983
- Erratum: Biosynthesis of retronecine (Journal of the American Chemical Society (1981) 103, (3208-3210)). Journal of the American Chemical Society. 104:2084. 1982
- The stereochemistry of the enzymic decarboxylation of L-arginine and of L-ornithine. Canadian Journal of Chemistry. 60:2810-2820. 1982
- Thiamin biosynthesis in yeast. Origin of the five-carbon unit of the thiazole moiety. Journal of the American Chemical Society. 104:4934-4943. 1982
- Additions and Corrections - Biosynthesis of Retronecine. Journal of the American Chemical Society. 104:2084-2084. 1982
- The biosynthesis of retronecine. Canadian Journal of Chemistry. 60:643-662. 1982
- 2H n.m.r. spectroscopy as a probe of the stereochemistry of biosynthetic reactions. The biosynthesis of nicotine. Chemical Communications. 0:662-662. 1982
- Biosynthesis of pyridoxol. The origin of the C2-unit, C-2',-2.. Journal of Biological Chemistry. 256:10469-10474. 1981
- ChemInform Abstract: BIOSYNTHESIS OF RETRONECINE. ChemInform. 12:no-no. 1981
- Biosynthesis of retronecine. Journal of the American Chemical Society. 103:3208-3210. 1981
- Phototoxic Furanoquinolines of the Rutaceae. Planta Medica. 41:136-142. 1981
- BIOSYNTHESIS OF PYRIDOXOL - THE ORIGIN OF THE C2-UNIT, C-2',-2. Journal of Biological Chemistry. 256:469-474. 1981
- Biosynthesis of the quinolizidine alkaloids. Incorporation of Δ¹-piperideine into matrine. Canadian Journal of Chemistry. 59:106-115. 1981
- The status of glycolaldehyde in the biosynthesis of vitamin B6.. Journal of Biological Chemistry. 255:3042-3048. 1980
- Biosynthesis of vitamin B1 in yeast. Origin of the thiazole unit. Journal of the American Chemical Society. 101:5102-5104. 1979
- The biosynthesis of the Lythraceae alkaloids. I. The lysine-derived fragment. Canadian Journal of Chemistry. 57:1606-1614. 1979
- The biosynthesis of the Lythraceae alkaloids. II. The phenylalanine-derived fragments. Canadian Journal of Chemistry. 57:1615-1630. 1979
- Thiamin biosynthesis in Saccharomyces cerevisiae. Origin of carbon-2 of the thiazole moiety. Biochemical Journal. 179:315-325. 1979
- The biosynthetic route from ornithine to proline.. Journal of Biological Chemistry. 254:640-647. 1979
- Deuterium NMR as a probe of the stereochemistry of enzyme reactions at prochiral centers. Deaminaton of cadaverine, catalyzed by diamine oxidase. Journal of the American Chemical Society. 100:7402-7404. 1978
- STEREOSPECIFICITY OF CONVERSION OF LYSINE INTO LUPANINE AND PIPECOLIC ACID IN LUPINUS-ANGUSTIFOLIUS. Polish Journal of Chemistry. 53:49-56. 1978
- Biosynthesis of vitamin B6. The incorporation of [1,3-13C2]glycerol. Journal of the American Chemical Society. 99:4179-4181. 1977
- The biosynthesis of the lupine alkaloids. A reexamination. Journal of the American Chemical Society. 98:6726-6728. 1976
- Biosynthesis of securinine: the mode of incorporation of lysine. Chemical Communications. 0:217-217. 1976
- Biosynthesis of vitamin B6. Incorporation of glycolaldehyde into pyridoxal. Organic and Biomolecular Chemistry. 0:1622-1622. 1975
- Stereochemistry of the enzymic decarboxylation of L-lysine. Chemical Communications. 0:378-378. 1975
- Biosynthesis of Corydaline and of Ochotensimine. Canadian Journal of Chemistry. 52:2818-2831. 1974
- Biosynthesis of Vitamin B₆. Incorporation of Terminally Labelled Glucose. Biochemistry and Cell Biology. 51:1412-1416. 1973
- ChemInform Abstract: A GENERAL METHOD FOR THE DETERMINATION OF PRECURSOR CONFIGURATION IN BIOSYNTHETIC PRECURSOR‐PRODUCT RELATIONSHIPS, DERIVATION OF PIPECOLIC ACID FROM D‐LYSINE, AND OF PIPERIDINE ALCALOIDS FROM L‐LYSINE. ChemInform. 4:no-no. 1973
- Biosynthesis of the piperidine nucleus. Incorporation of chirally labeled cadaverine-1-3H. Journal of the American Chemical Society. 95:4715-4725. 1973
- General method for the determination of precursor configuration in biosynthetic precursor-product relations. Derivation of pipecolic acid from D-lysine, and of piperidine alkaloids from L-lysine. Journal of the American Chemical Society. 95:4040-4047. 1973
- Biosynthesis of Vitamin B6. Journal of Biological Chemistry. 247:1869-1882. 1972
- ChemInform Abstract: SPEZIFISCH (14)C‐MARKIERTES 2‐ALLYL‐PIPERIDIN. Chemischer Informationsdienst Organische Chemie. 2:no-no. 1971
- Spezifisch ¹⁴C‐markiertes 2‐Allyl‐piperidin. Chemische Berichte. 104:1967-1975. 1971
- Additions and Corrections - Biosynthesis of Pyridoxine. Journal of the American Chemical Society. 93:1828-1828. 1971
- Biosynthesis of pyridoxine. Journal of the American Chemical Society. 93:518-520. 1971
- Biosynthesis of the piperidine nucleus: The occurrence of two pathways from lysine. Phytochemistry. 9:2329-2334. 1970
- Biosynthesis of Vitamin B ₆ : Incorporation of Three-Carbon Units. Science. 169:773-775. 1970
- Biosynthesis of lycopodine. Incorporation of pelletierine. Journal of the American Chemical Society. 92:1074-1075. 1970
- Biosynthesis of the Lycopodium alkaloids: the origin of cernuine. Journal of the Chemical Society D: Chemical Communications. 0:409-409. 1970
- Biosynthesis of the lythraceae alkaloids: incorporation of lysine. Journal of the Chemical Society D: Chemical Communications. 0:396-396. 1970
- Biosynthesis of the lythraceae alkaloids: mode of incorporation of phenylalanine. Journal of the Chemical Society D: Chemical Communications. 0:897-897. 1970
- Biosynthesis of N-methylpelletierine. Phytochemistry. 8:1937-1944. 1969
- Biosynthesis of aristolochic acid. Canadian Journal of Chemistry. 47:481-487. 1969
- Biosynthesis of the Piperidine Nucleus. Journal of Biological Chemistry. 244:88-94. 1969
- Biosynthesis of lycopodine. Journal of the American Chemical Society. 90:1360-1361. 1968
- Biosynthesis of the piperidine alkaloids: origin of the piperidine nucleus of N-methylisopelletierine. Chemical Communications. 0:85-85. 1968
- Biosynthesis of dictamnine. The origin of the quinoline nucleus. Canadian Journal of Chemistry. 45:1935-1948. 1967
- Biosynthesis of mimosine: Incorporation of serine and of α-aminoadipic acid. Phytochemistry. 6:1245-1248. 1967
- The biosynthesis of sedamine. Canadian Journal of Chemistry. 45:1275-1285. 1967
- Biosynthesis of the alkaloids related to norlaudanosoline. Journal of natural products. 29:71-89. 1966
- Biosynthesis of the piperidine alkaloids. The C₆–C₂units of sadamine and lobinaline. Chemical Communications. 0:893-894. 1966
- Biosynthesis of aristolochic acid. Chemical Communications. 0:55-55. 1966
- Biosynthesis of dictamnine. Chemical Communications. 0:204-204. 1966
- PRECURSORS OF MIMOSINE IN MIMOSA PUDICA. Biochemistry and Cell Biology. 43:1687-1691. 1965
- BIOSYNTHESIS OF BERBERINE AND BERBERASTINE INCORPORATION OF CATECHOLAMINES. Canadian Journal of Chemistry. 43:2017-2026. 1965
- Biosynthesis of Berberastine. Journal of the American Chemical Society. 87:1137-1138. 1965
- BIOSYNTHETIC INCORPORATION OF ONE-CARBON UNITS INTO BERBERINE AND HYDRASTINE. Canadian Journal of Chemistry. 43:133-144. 1965
- BIOSYNTHESIS OF MIMOSINE: INCORPORATION OF ASPARTIC ACID INTO THE PYRIDONE NUCLEUS. Biochemistry and Cell Biology. 42:1803-1808. 1964
- D-17-3 Biosynthesis of Mimosine(Biosynthesis) 1964
- THE NUCLEAR MAGNETIC RESONANCE SPECTRA OF THE CARBOLINES. Canadian Journal of Chemistry. 42:954-956. 1964
- The Carbolines. Advances in Heterocyclic Chemistry. 3:79-207. 1964
- One-carbon units in the biosynthesis of hydrastine and berberine. Biochemical and Biophysical Research Communications. 13:115-120. 1963
- Biosynthesis of berberine. Proceedings of the Chemical Society. 228-229. 1962
- 3,4-DIHYDRO-β-CARBOLINES: I. THE ALKYLATION OF 1-SUBSTITUTED N_β-ALKYL-3,4-DIHYDRO-β-CARBOLINE ANHYDRO BASES. Canadian Journal of Chemistry. 40:2041-2048. 1962
- 3,4-DIHYDRO-β-CARBOLINES: II. THE EXHAUSTIVE METHYLATION OF 3,4-DIHYDRO-β-CARBOLINE. Canadian Journal of Chemistry. 40:2049-2056. 1962
- A SYNTHESIS OF MIMOSINE. Canadian Journal of Chemistry. 40:1374-1379. 1962
- The Biosynthetic Incorporation of Dopamine into Hydrastine. Journal of the American Chemical Society. 84:1059-1060. 1962
- α-amino-acids and α-keto-acid oximes from α- hydroxylamino-acids: A new disproportionation reaction. Proceedings of the Chemical Society. 375-376. 1961
- Biosynthesis of Hydrastine. Nature. 191:1393-1395. 1961
- A SYNTHESIS OF HARMALINE. Canadian Journal of Chemistry. 37:1851-1858. 1959
- 743. The isomeric pyruvamide phenylhydrazones. Journal of the Chemical Society. 0:3767-3767. 1957
- The structure of nβ-alkyl-β-carboline anhydro-bases. Journal of the Chemical Society. 3640-3642. 1956
- THE BIOGENESIS OF ALKALOIDS. Journal of Biological Chemistry. 214:71-77. 1955
- THE BIOGENESIS OF ALKALOIDS: XIV. A STUDY OF THE BIOSYNTHESIS OF DAMASCENINE AND TRIGONELLINE. Canadian Journal of Chemistry. 33:405-410. 1955
- THE BIOGENESIS OF ALKALOIDS: XII. THE MODE OF FORMATION OF THE TROPINE BASE OF HYOSCYAMINE. Canadian Journal of Chemistry. 32:1116-1123. 1954
- Biogenesis of Hyoscyamine. Nature. 174:650-651. 1954
theses
- THE BIOSYNTHESIS OF HYDRASTINE AND BERBERINE. Canadian Journal of Chemistry. 1963