Growth response to 4‐hydroxy‐<scp>l</scp>‐threonine of <i>Escherichia coli</i> mutants blocked in vitamin B<sub>6</sub> biosynthesis

Mutants of Escherichia coli (pdx B and pdx C) which are blocked in the biosynthesis of pyridoxol (vitamin B6) showed a growth response to 4‐hydroxy‐l‐threonine. This observation constitutes the first direct evidence in support of the view that 4‐hydroxy‐l‐threonine is implicated in the biosynthesis of vitamin B6. 1‐Aminopropan‐2,3‐diol, the decarboxylation product of 4‐hydroxy‐l‐threonine, does not support the growth of these mutants. Deuterium from deuterium‐labelled 1‐aminopropan‐2,3‐diol was not incorporated into pyridoxol.

Growth response to 4‐hydroxy‐l‐threonine of Escherichia coli mutants blocked in vitamin B₆ biosynthesis Journal Articles