Biosynthesis of Corydaline and of Ochotensimine Academic Article uri icon

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abstract

  • Radioactivity from [3-14C]tyrosine and from [methyl-14C]methionine is incorporated nonrandomly into predicted positions of corydaline and ochotensimine in Corydalissolida and C. ochotensis, respectively. The methyl group of methionine supplies the C-methyl group of corydaline and the exocyclic methylene group of ochotensimine, as well as the "bridge" carbon atom and the exocyclic O- and N-attached one-carbon units of each alkaloid. Maintenance of the 3H/14C ratio of [methyl-3H,14C]methionine within these units of corydaline is consistent with incorporation of intact CH3 groups.Partial loss of 3H relative to 14C is observed in the course of a Schmidt reaction of [2-3H, 2-14C] acetate.

publication date

  • August 1, 1974