Biosynthesis of Corydaline and of Ochotensimine Journal Articles uri icon

  •  
  • Overview
  •  
  • Research
  •  
  • Identity
  •  
  • Additional Document Info
  •  
  • View All
  •  

abstract

  • Radioactivity from [3-14C]tyrosine and from [methyl-14C]methionine is incorporated nonrandomly into predicted positions of corydaline and ochotensimine in Corydalissolida and C. ochotensis, respectively. The methyl group of methionine supplies the C-methyl group of corydaline and the exocyclic methylene group of ochotensimine, as well as the "bridge" carbon atom and the exocyclic O- and N-attached one-carbon units of each alkaloid. Maintenance of the 3H/14C ratio of [methyl-3H,14C]methionine within these units of corydaline is consistent with incorporation of intact CH3 groups.Partial loss of 3H relative to 14C is observed in the course of a Schmidt reaction of [2-3H, 2-14C] acetate.

publication date

  • August 1, 1974