selected scholarly activity
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chapters
- Oncodynamic Changes in Skeleton. 175-209. 2016
- Use of Tetracyclines for Bone Metastases. Cancer Drug Discovery and Development. 293-303. 2005
- Comparative Morphometric Study on Bone Remodeling in Human Specimens and in Experimental Models of Metastatic Bone Disease. Cancer Metastasis - Biology and Treatment. 31-48. 2004
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conferences
- "Fact-Ways": Teaching Cellular Signaling Using The Nobel Archives. The FASEB Journal. 2016
- A Novel Pre-clinical Model of Cancer-Induced Depression. Biological Psychiatry. 54S-54S. 2015
- Abstract 3687: Analgesic effects of capsazepine on a mouse model of bone cancer pain. Cancer Research. 3687-3687. 2014
- Examination of the mechanism(s) of cancer-induced bone pain in animal models. Bone. S39-S39. 2011
- Glutamate release in bone metastasis. Bone. S32-S32. 2011
- Characterization of glutamate transporters in cancer cells: Implications on normal bone formation.. Cancer Research. 2009
- Metastatic cancer cells release glutamate to disrupt bone turnover.. Cancer Research. 2009
- Spinal astrogliosis in an animal model of cancer-induced bone pain. Cancer Research. 2006
- 1085. In Vivo Imaging of Microencapsulated Gene Therapy. Molecular Therapy. S416-S416. 2006
- Cyclooxygenase isoenzymes and patency of ductus arteriosus. Prostaglandins Leukotrienes and Essential Fatty Acids. 71-77. 2005
- Treatment of bone metastasis with a combination of doxycycline and zoledronate. Journal of Bone and Mineral Research. 1596-1597. 2004
- Cyclooxygenase in the lamb ductus arteriosus: Developmental changes and upregulation. ADVANCES IN PROSTAGLANDIN AND LEUKOTRIENE RESEARCH: BASIC SCIENCE AND NEW CLINICAL APPLICATIONS. 135-137. 2001
- Deletion of the Endothelin-A-Receptor Suppresses Oxygen-Induced Constriction but not Postnatal Closure of the Ductus Arteriosus. Journal of Cardiovascular Pharmacology. S75-S77. 2000
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journal articles
- Behavioural Effects of Using Sulfasalazine to Inhibit Glutamate Released by Cancer Cells: A Novel target for Cancer-Induced Depression. Scientific Reports. 7:41382. 2017
- Differences in electrophysiological properties of functionally identified nociceptive sensory neurons in an animal model of cancer-induced bone pain. Molecular Pain. 12:174480691662877-174480691662877. 2016
- Depressive-like behaviours and decreased dendritic branching in the medial prefrontal cortex of mice with tumors: A novel validated model of cancer-induced depression. Behavioural Brain Research. 294:25-35. 2015
- Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain. Pain. 155:28-36. 2014
- Oxidative stress and cancer pain. Canadian Journal of Physiology and Pharmacology. 91:31-37. 2013
- Glutamate Signaling in Healthy and Diseased Bone. Frontiers in Endocrinology. 3:89. 2012
- Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone. Human Pathology. 41:1320-1329. 2010
- Extracellular glutamate alters mature osteoclast and osteoblast functions. Canadian Journal of Physiology and Pharmacology. 88:929-936. 2010
- A by-product of glutathione production in cancer cells may cause disruption in bone metabolic processesThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.. Canadian Journal of Physiology and Pharmacology. 88:197-203. 2010
- Cancer cells release glutamate via the cystine/glutamate antiporter. Biochemical and Biophysical Research Communications. 391:91-95. 2010
- Cancer cell lines release glutamate into the extracellular environment. Clinical and Experimental Metastasis. 26:781-787. 2009
- Luciferase Therapeutic Microcapsules for Gene Therapy. Artificial Cells, Nanomedicine and Biotechnology. 37:235-244. 2009
- Effect of zoledronic acid on the doxycycline-induced decrease in tumour burden in a bone metastasis model of human breast cancer. British Journal of Cancer. 96:1526-1531. 2007
- Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth. Oncogene. 23:5632-5642. 2004
- Quantification of anti-angiogenesis using the capillaries of the chick chorioallantoic membrane demonstrates that the effect of human angiostatin is age-dependent. Microvascular Research. 67:105-116. 2004
- The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer.. Cancer Research. 63:7979-7985. 2003
- Malignant Ascites Fluid (MAF), Including Ovarian-Cancer-Associated MAF, Contains Angiostatin and Other Factor(s) Which Inhibit Angiogenesis. Gynecologic Oncology. 86:279-287. 2002
- The response of the lamb ductus arteriosus to endothelin: developmental changes and influence of light. Life Sciences. 71:1209-1217. 2002
- Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer.. Cancer Research. 62:1588-1591. 2002
- Metabolism of rabbit angiostatin glycoforms I and II in rabbits: Angiostatin-I leaves the intravascular space faster and appears to have greater anti-angiogenic activity than angiostatin-II. Translational Research. 138:83-93. 2001
- Function of cyclo‐oxygenase‐1 and cyclo‐oxygenase‐2 in the ductus arteriosus from foetal lamb: differential development and change by oxygen and endotoxin. British Journal of Pharmacology. 132:241-251. 2001
- Ascites fluid induces epithelial proliferation and increases vascular permeability in the chorioallantoic membrane. Prostaglandins and Other Lipid Mediators. 59:175-175. 1999
- Endothelin A receptor is necessary for O-2 constriction but not closure of ductus arteriosus. American Journal of Physiology. 277:H1521-H1531. 1999
- Endothelin A receptor is necessary for O2constriction but not closure of ductus arteriosus. American Journal of Physiology. Heart and Circulatory Physiology. 277:H1521-H1531. 1999
- Carbon monoxide formation in the ductus arteriosus in the lamb: implications for the regulation of muscle tone. British Journal of Pharmacology. 120:599-608. 1997
- Carbon monoxide‐induced relaxation of the ductus arteriosus in the lamb: evidence against the prime role of guanylyl cyclase. British Journal of Pharmacology. 118:1689-1696. 1996
- Inhibition of the contraction of the ductus arteriosus to oxygen by 1‐aminobenzotriazole, a mechanism‐based inactivator of cytochrome P450. British Journal of Pharmacology. 117:1586-1592. 1996
- Post-activation potentiation and depression in the neocortex of the rat: II. Chronic preparations. Brain Research. 637:83-96. 1994
- Occurrence of endothelium-derived relaxing factor – nitric oxide in the lamb ductus arteriosus. Canadian Journal of Physiology and Pharmacology. 72:82-88. 1994
- Evidence for an effector role of endothelin in closure of the ductus arteriosus at birth. Canadian Journal of Physiology and Pharmacology. 70:1061-1064. 1992
- Effects of central and peripheral neuropeptide Y on sodium and water excretion in the rat. Physiology and Behavior. 46:9-11. 1989
- Regulation of renal function by central neuropeptide Y in the anesthetized rat.. Proceedings of the Western Pharmacology Society. 32:281-284. 1989
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theses