Comparative Morphometric Study on Bone Remodeling in Human Specimens and in Experimental Models of Metastatic Bone Disease

Metastatic cancer is the most common malignant tumor affecting bone and is accompanied by significant clinical morbidity, including pain, osteolysis, pathological fracture, spinal compression syndromes and hypercalcemia. Bone destruction is a marked clinical feature and the major source of morbidity associated with bone metastases. Most of these clinical features can be related to structural changes in bone that are caused by effects of the tumor on normal processes of bone remodeling.