Journal article
Cancer cells release glutamate via the cystine/glutamate antiporter
Abstract
Although the amino acid glutamate is used as an intercellular signaling molecule for normal bone homeostasis, little is known regarding its possible role in the metabolic disruption characteristic of bone metastasis. We have previously shown in vitro that cancer cell lines relevant to bone metastasis release glutamate into the extracellular environment. This study demonstrates the expression of multiple glutamate transporters in cancer cell …
Authors
Sharma MK; Seidlitz EP; Singh G
Journal
Biochemical and Biophysical Research Communications, Vol. 391, No. 1, pp. 91–95
Publisher
Elsevier
Publication Date
January 2010
DOI
10.1016/j.bbrc.2009.10.168
ISSN
0006-291X