Cloning of a Chinese hamster protein homologous to the mouse t-complex protein TCP-1: Structural similarity to the ubiquitous ‘chaperonin’ family of heat-shock proteins

The complete cDNA sequence of a Chinese hamster ovary cell protein, homologous to a mouse t-complex protein, TCP-1, has been determined. The deduced amino acid sequences of the mouse/Chinese hamster TCP-1 proteins exhibit significant identity to the 60-65 kDa heat shock 'chaperonin' family of proteins present in prokaryotes and in the eukaryotic cell organelles.