Journal article
A novel stem cell culture model of recurrent glioblastoma
Abstract
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults with average disease relapse at 9 months and median survival rarely extending beyond 15 months. Brain tumor stem cells (BTSCs) have been implicated in not only initiating GBM but also conferring resistance to therapy. However, it is not clear whether the BTSC population that initiates tumor growth is also responsible for GBM recurrence. In this study, we have …
Authors
Qazi MA; Vora P; Venugopal C; McFarlane N; Subapanditha MK; Murty NK; Hassell JA; Hallett RM; Singh SK
Journal
Journal of Neuro-Oncology, Vol. 126, No. 1, pp. 57–67
Publisher
Springer Nature
Publication Date
January 2016
DOI
10.1007/s11060-015-1951-6
ISSN
0167-594X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAged, 80 and overAnalysis of VarianceAntigens, CDAntinematodal AgentsAntineoplastic AgentsBrain NeoplasmsCell Self RenewalDose-Response Relationship, DrugFemaleFlow CytometryGene Expression Regulation, NeoplasticGlioblastomaHumansMaleMiddle AgedNeoplastic Stem CellsPolycomb Repressive Complex 1SOXB1 Transcription FactorsTumor Cells, Cultured