Journal article
Orientation and Effects of Mastoparan X on Phospholipid Bicelles
Abstract
Mastoparan X (MPX: INWKGIAAMAKKLL-NH2) belongs to a family of ionophoric peptides found in wasp venom. Upon binding to the membrane, MPX increases the cell's permeability to cations leading to a disruption in the electrolyte balance and cell lysis. This process is thought to occur either through a membrane-thinning mechanism, where the peptide resides on the membrane surface thereby disrupting lipid packing, or through formation of an …
Authors
Whiles JA; Brasseur R; Glover KJ; Melacini G; Komives EA; Vold RR
Journal
Biophysical Journal, Vol. 80, No. 1, pp. 280–293
Publisher
Elsevier
Publication Date
January 2001
DOI
10.1016/s0006-3495(01)76013-4
ISSN
0006-3495