Biophysical Journal - McMaster Experts

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Computational Study of Ion Selectivity in Eukaryotic Voltage-Gated Sodium Channels 2021
Dynamical Basis of Allosteric Activation for the Plasmodium falciparum Protein Kinase G 2021
Erythro-VLP: Erythrocyte Virus-Like-Particles 2021
Non-Classical Protein Kinase a Activation by Aggregation of the PKA R-Subunits as a Mechanism of Inherited Carney Complex Mutations 2021
Phenylakylamines in Calcium Channels. Experimental Structures and Computational Models 2020
Rotational and Translational Drag Coefficients of a Helical Bacterial Cell 2020
Structural Basis of Alpha Synuclein Assembly Toxicity Inhibition by Human Serum Albumin 2020
The Influence of Lipid Tail Composition on Bid-Mediated Bax Pore Formation 2020
Using Fluorescence Correlation Spectroscopy to Accurately Measure Protein Concentration Gradients in the Presence of Noise and Photobleaching 2020
Chromatin Remodeling Induced by the Invasion of Yeast Pioneer Transcription Factor Rap1 Revealed by Single-Molecule FRET 2019
Possible Mechanism of Calcium-Dependent Block of L-Type Calcium Channel by Glacontryphan-M 2019
Predicting Variant Pathogenicity in the Cardiac Sodium Channel using Paralogue Annotation 2019
Timothy Syndrome-Associated Mutations Affect State-Dependent Contacts in L-Type Calcium Channel 2019
Understanding the Structural Basis of Recognition between Plasmodium Falciparum and Human Sumoylation Machinery 2018
Anomalous Diffusion as Seen through the Lens of Inverted Variable Length Scale FCS 2018
Measuring the Effective Temperature of Single Magnetotactic Bacteria as a Tool to Study Non-Thermal Biological Noise 2018
Mechanism of Selective Resistance of the Bumble Bee Sodium Channel BiNaV1 to TAU-Fluvalinate 2018
Membrane Cholesterol Reduces Polymyxin B Nephrotoxicity in Renal Membrane Analogues 2018
Sequence and 3D Alignments of the Pore-Lining Helices in P-Loop Channels Reveal their Conserved and Variable Features 2018
The Molecular Structure of Human Red Blood Cell Membranes From Highly Oriented, Solid Supported Multi-Lamellar Membranes 2018
A Hidden Markov Model Approach to Measure Two-State Diffusion of Thermobifida Fusca Cellulases 2017
The Sodium Ion Binding Region at the Focus of P1 Helices Attracts both Charged and Electroneutral Ligands of Sodium Channels 2017
Zooming in on Anomalous Diffusion with Variable-Lengthscale Fluorescence Correlation Spectroscopy 2017
Investigating Diffusion of Receptors on Macrophage Membranes using Single Molecule Tracking 2016
Mapping Receptor Sites for Sodium Channel Blocking Insecticides DCJW and Metaflumizone in an Insect Sodium Channel 2016
Mechanism of Cyclic AMP Partial Agonism in Protein Kinase G (PKG) 2016
A Tool Set to Map Dynamic Allosteric Networks through the NMR Chemical Shift Covariance Analysis (CHESCA) 2015
Determinants of Self Aggregation of H-Tel 2015
Rotational Symmetry of Two Pyrethroid Receptor Sites in the Mosquito Sodium Channel 2015
Single-Molecule Fluorescence Microscopy and Tracking of Lipids in Mitochondrial-Like Supported Lipid Bilayers 2015
Finding Order in Disorder: Probing Transient Functional States in the Amyloidogenic Alzheimer's Aβ Peptide Using the NMR Chemical Shift Covariance Analysis (CHESCA) 2014
NavAb Structure as a Template to Rationalize Experimental Data on Nav1.4 Block by Mu-Conotoxins 2014
Binding and Oligomerization of Bcl-2 Family Proteins on Supported Lipid Bilayers with Single Molecule Resolution 2013
Exceptionally Conserved Asparagines in the Pore-Lining Helices of Calcium and Sodium Channels Stabilize the Open State through Interdomain H-Bonds 2013
Interaction of Local Anesthetics with KcsA K+ Channel: Tetramer Stability and Docking Simulations 2013
A Supported Bilayer Model to Study the Effect of Membrane Composition on Bcl-2 Family Proteins 2012
Characterizing Bax and Bid Binding to Liposomes and Planar Membranes with Single Molecule Resolution 2012
Concentration-Dependent Structural Transitions of Human Telomeric DNA Sequences 2012
Modeling Block of the Kv1.5 Channel by Cationophilic and Cationic Ligands: Implications for General Mechanisms of the Inner Pore Block in P-Loop Channels 2012
Quantification of Protein Distribution on Liposomes using Confocal Microscopy: A Single Mobile Fluorescent Particle Detection Method 2012
Selectivity Filter Region, Tetrodotoxin and Local Anesthetics in the NavAb-based Model of the Nav1.4 Channel 2012
tBid Conformational Changes at the Membrane for the Regulation of Apoptosis 2012
Detecting Critical Fluctuations in Ternary Lipid and Cholesterol Mixtures 2011
Detection of Mobile Single Fluorescent Particles by Confocal Microscopy: A Comparison with Fluorescence Correlation Techniques 2011
Do Cellulases Exhibit Diffusion Along Cellulose Surfaces? Evidence from FRAP and Single Molecule Experiments 2011
Investigating Cellulase Synergistic Binding and Activity on Simple and Complex Cellulose Morphological Structures 2011
PySM an Integrated Data Management and Analysis Platform for Single Molecule Experimentation 2011
Bax Pore Formation: From Activation to Oligomerization 2010
Binding Kinetics and Fraction of Immobile Enzymes Bound to Cellulose Fibrils Studied Through Confocal Laser Scanning Fluorescence Microscopy and FRAP 2010
Cellulase Enzyme Binding to Pre-Treated Biomass Particles Using Confocal Fluorescence Microscopy 2010
Differential Regulation of β-Adrenergic Signaling Via Phosphoinositide-3-Kinase-γ 2010
Effect of Different Lipid Compositions on Mitochondrial Outer Membrane Permeabilization Assisted by the Pro-Apoptotic Proteins tBID and BAX 2010
Engineered Nanolipoproteins as Biosynthetic Decoys for Pathogen-Binding 2010
In-Silico Activation and Deactivation of the Pore Domains of Voltage- and Ligand-Gated Ion Channels 2010
Investigation of the Effects of Cellulose Morphology on Synergism in Cellulase Mixtures using Quantitative Fluorescence Microscopy 2010
Modeling the Outer Pore of Sodium and Calcium Channels 2010
Potassium Channel Block by a Tripartite Complex of Neutral Ligands with a Potassium Ion 2010
Sub-Diffusion and Super-Diffusion of Hydration Water Molecules at Biological Interfaces 2010
Surface Diffusion of Cellulases on Cellulose Fibrils Studied through Fluorescence Spectroscopy 2010
ATP-evoked Ca2±waves Stimulate Gene Expression In Human Airway Fibroblasts 2009
Binding of the Pro-Apoptotic protein Bid to Mitochondrial Membranes is a Two Step Process 2009
Combined pH and Temperature Measurements Using Pyranine as a Probe 2009
Elucidating the Molecular Basis of Cellulase Synergism Through High Resolution Quantitative Fluorescence Microscopy 2009
Fluorescence Correlation Spectroscopy with Sub-Diffraction-Limited Resolution Using Near-field Optical Probes 2009
Fluorescence Labeling And Purification Of Cellulases For Single Molecule Spectroscopy 2009
GCN4 Enhances the Stability of the Pore Domain of Potassium Channel KcsA 2009
Mapping the Binding Site of the Alkoxypsoralen PAP-1 in the Voltage-Gated K+ Channel Kv1.3 2009
Mechanical Properties of Type IV Pili in Pseudomonas Aeruginosa 2009
Modeling L-type Calcium Channel with Dihydropyridines 2009
Modeling L-type Calcium Channel with Phenylalkylamines 2009
Myelin Structural Integrity in a Model for Human Early-Onset CMT1B 2009
Reinterpretation of SCAM Data in View of Kv1.2-based Models of MTSET-Substituted CaV2.1 Channels 2009
Solvent Exposure- and Distance-Dependent Dielectric Function for Ligand-Protein Interactions 2009
The Bcd Morphogenetic Concentration Gradient is Formed by Diffusion 2009
The Toxic Effects of Quantum Dots on Embryogenesis in Caenorhabditis elegans 2009
Thermally-induced Activation Of TRPV2 Channels Causes Cell Death In Airway Smooth Muscle 2009
Bilayer thickness and thermal response of DMPC unilamellar vesicles containing cholesterol, ergosterol and lanosterol 2007
Cell investigation of sub-wavelength optical nanostructures: plasma membrane studies with single molecule resolution 2007
Collective excitations of the two-dimensional protein lattice of Bacteriorhodopsin in purple membrane 2007
Curvature effect on the structure of phospholipid bilayers 2007
Effect of farnesol on phospholipid membranes 2007
Exploring the access and binding of local anesthetics in the resting cardiac sodium channel using monte carlo-energy minimization 2007
Molecular modeling of slow inactivation and state-dependent drug binding in sodium channels 2007
Observations using variable length scale fluorescence correlation spectroscopy 2007
Permeabilization of membranes by bax 2007
Spatial distribution and mobility of the protein Ran in live interphase cells 2007
The voltage-dependent block of d-Tubocurarine on mKv1.3 voltage-gated potassium channels 2007
Anomalous diffusion due to molecular crowding in model systems and living cells studied by fluorescence correlation spectroscopy 2005
Collective dynamics of lipid membranes studied by inelastic neutron scattering 2005
Detection of submicron-sized domains or so-called "rafts" in membranes by small-angle neutron scattering 2005
Molecular modeling suggests the mechanism of action of batrachotoxin and veratridine on the sodium channel 2005
Polyelectrolytes and polyelectrolyte nanocapsules: Valuable tools for FRET and FRAP measurements using 3D microscopy. 2005
Structural conservation of prokaryotic and eukaryotic voltage-gated potassium channels deduced from the action of cadmium and organic blockers on the open shaker channel 2005
Ternary complex of Kv1.3 channel correolide, and potassium ion predicted by Monte Carlo-energy minimization 2005
Expression and structural characterization of large fragments of the mu-opioid receptor 2004
Influence of cholesterol and temperature on the thickness of SOPC and DOPC unilamellar vesicles measured by small-angle neutron scattering 2004
Investigation of the oligomerization of Bax at the membrane of a giant vesicle 2004
Lipid and high resolution surface chemical patterning 2004
Effects of cholesterol on thermo mechanical properties of large unilamellar vesicles 2003
Sarcoplasmic reticulum Ca2+ release modulates BKCa channel activity in mesenteric artery of spontaneously hypertensive rat 2003
Vasodilatory and hyperpolarizing effects of 8-iso PGE(2) in coronary and renal arteries 2003
Homology model of the pore region of L-type Ca2+ channel in the open state 2002
Isoprostanes may represent novel candidates for EDHF! 2002
K+ and Ca2+ currents in bronchial arterial smooth muscle 2002
Particle-induced changes in fluctuations and curvature of giant and large unilamellar vesicles 2002
DOCKING of tetrandrine in L-type Ca(2+)CHANNEL. 2001
Dehydration of hydrophobic groups as a driving force for binding of antifreeze proteins to ice. 2001
Homology model of dihydropyridine receptor suggests how antagonists and agonists modulate L-type Ca2+ channel. 2001
Shape changes of large unilamellar vesicles - A test of the Area Difference Elasticity Model 2001
Homology modeling of L-type calcium channel with agonists and antagonists. 2000
Modeling chloride channels of glycine and GABA receptors with blockers. 2000
NO+ (but not NO) relaxes airway smooth muscle via cGMP-independent release of Ca2+ 2000
Osmotically induced shape changes to large unilamellar vesicles: Effects of lipid and solute composition 2000
A zero-net-charge model of mu-opioid receptor with bound agonists and antagonists. 1999
Continuous recycling of Ca2+ between a caffeine-sensitive CPA-insensitive Ca2+-pool and the sarcolemma in canine pulmonary vasculature. 1999
Interfacial morphologies of the phospholipids DPPC and POPE in excess water using small angle neutron scattering 1999
Membrane currents, [Ca2+]-transients and contractions indicate a superficial buffer barrier in airway smooth muscle 1998
Interaction of Ca2+ with drugs and receptors. Modeling studies on a synthetic calcium channel peptide. 1997
Signal transduction within G-protein coupled receptors via an ion tunnel? Inference from modeling mu-opioid receptor with agonists. 1997
Characterization of calmodulin-binding peptides using phage-display random peptide libraries 1996
Fluorescence monitoring of the reversible unfolding of F102W and F102(7AW) rat parvalbumin in aqueous solution. 1996
Probing protein unfolding reactions using non-natural amino acids: An examination of wild type and W92(7AW) tryptophanyl tRNA synthetase using fluorescence techniques. 1996
Self-quenching of nitrobenzoxadiazole labeled phospholipids in lipid membranes. 1996
APPLICATION OF SMALL-ANGLE NEUTRON-SCATTERING TO DETERMINE PROPERTIES OF THE MEMBRANE-WATER INTERFACE 1994
CA2+-BOUND CONFORMATIONS OF MET-ENKEPHALIN AND MORPHINE ARE SIMILAR 1994
CHARACTERIZATION OF THE CALMODULIN-BINDING OF A 22-MER PEPTIDE FROM A M13 PHAGE LIBRARY 1994
PHOTOPHYSICS OF 7-AZATRYPTOPHAN - EVIDENCE FOR AN EXCITED-STATE REACTION 1994
TIME-RESOLVED FLUORESCENCE OF ENANTIOMERS OF MODEL PEPTIDES CONTAINING 7-AZATRYPTOPHAN 1994
CA-2+ IONOPHORETIC ACTIVITIES OF PEPTIDE-HORMONES AND DRUGS 1993
POTASSIUM CHANNELS IN THP-1 HUMAN MONOCYTES 1993
CHEMOTRANSDUCTION MECHANISMS DETERMINED BY 2 METHODS OF WHOLE-CELL RECORDING 1990
LUMINAL RESPONSES TO SUBSTANCE-P ON RAT TRACHEA 1988
FUNCTIONAL SUBTYPING OF THE LUMINAL TACHYKININ RECEPTOR ON CANINE TRACHEAL EPITHELIUM 1987
MEMBRANE CONDUCTANCE CHANGES BY ANAPHYLACTIC STIMULATION IN RAT BASOPHILIC LEUKEMIA (2H3) CELLS 1987
EACHYKININS ON THE ISOLATED CANINE TRACHEAL EPITHELIUM - AN ANALYSIS OF THE DIP 1986
ELECTROTONIC CURRENT SPREAD IN THE CIRCULAR MUSCLE LAYER OF THE DOG COLON 1986
MYOGENIC ELECTRICAL CONTROL ACTIVITY OF HUMAN AND DOG COLON SMOOTH-MUSCLE IS ASSOCIATED WITH CALCIUM-CHANNEL ACTIVATION 1985
SUBSTANCE-P AND RELATED TACHYKININS ON ISOLATED CANINE TRACHEAL EPITHELIUM 1985
EFFECT OF AG+ ON ISOLATED BULLFROG GASTRIC-MUCOSA 1984
THE SODIUM-PUMP IN VASCULAR SMOOTH-MUSCLE 1983
Both the transcriptional activator, Bcd, and repressor, Cic, form small mobile oligomeric clusters.. S0006-3495(24)00558-7. 2024
Combining AlphaFold and molecular dynamics simulations to determine the complete structures of isoforms of human brain-derived neurotrophic factor and human nerve growth factor. 123:201a-201a. 2024
Identification of core allosteric sites through temperature- and nucleus-invariant chemical shift covariance. 121:2035-2045. 2022
Fatty acids mediate hepatocyte calcium release and ER stress induction after traumatic injury. 121:375a-375a. 2022
Using FCS to accurately measure protein concentration in the presence of noise and photobleaching. 120:4230-4241. 2021
Platelet Factor 4 Interactions with Short Heparin Oligomers: Implications for Folding and Assembly. 119:1371-1379. 2020
Allosteric Mechanisms of Nonadditive Substituent Contributions to Protein-Ligand Binding. 119:1135-1146. 2020
ER Stress Directly Activates Inflammatory Responses through Damp Production. 118:46a-46a. 2020
Mechanism of Allosteric Inhibition of Plasmodium falciparum CGMP-Dependent Protein Kinase. 118:522a-522a. 2020
Membrane Remodeling by the Lytic Fragment of SticholysinII: Implications for the Toroidal Pore Model. 117:1563-1576. 2019
Anomalous Diffusion in Inverted Variable-Lengthscale Fluorescence Correlation Spectroscopy. 116:791-806. 2019
Chronic ER Stress Leads to Hepatic Damp Production. 116:336a-336a. 2019
Modulation of DEG/ENaCs by Amphiphiles Suggests Sensitivity to Membrane Alterations. 114:1321-1335. 2018
Characterization of Phases and Interactions Among Lipids Involved in Drug Delivery: An NMR and Small-Angle X-Ray Scattering Study. 114:16a-16a. 2018
Computational and Experimental Study of Dope and Pope Lipids in the Inverted Hexagonal Phase: Effect of Water per Lipid, Temperature, Salt Concentration, and Simulation Setup. 114:606a-606a. 2018
Membrane Cholesterol Reduces Polymyxin B Nephrotoxicity in Renal Membrane Analogs. 113:2016-2028. 2017
The Characterization of Cellulose Nanostructure using Super-Resolution Fluorescence Microscopy. 112:144a-144a. 2017
Disordered Regions Flanking Ordered Domains Modulate Signaling Transduction. 109:2447-2448. 2015
Nanoscale Pulling of Type IV Pili Reveals Their Flexibility and Adhesion to Surfaces over Extended Lengths of the Pili. 108:2865-2875. 2015
Direct Measurements of Drag Forces in C. elegans Crawling Locomotion. 107:1980-1987. 2014
Signaling at Crossroads: The Dialogue between PDEs and PKA is Spoken in Multiple Languages. 107:1259-1260. 2014
Critical Behaviour in DOPC/DPPC/Cholesterol Mixtures: Static 2H NMR Line Shapes Near the Critical Point. 106:1970-1978. 2014
The Proapoptotic Protein tBid Forms Both Superficially Bound and Membrane-Inserted Oligomers. 106:2085-2095. 2014
Mapping the Interactions between the Alzheimer’s Aβ-Peptide and Human Serum Albumin beyond Domain Resolution. 105:1700-1709. 2013
Aβ Association Inhibition by Transferrin. 105:473-480. 2013
Correction. 102:719-719. 2012
Insights into Photodynamic Therapy Dosimetry: Simultaneous Singlet Oxygen Luminescence and Photosensitizer Photobleaching Measurements. 102:661-671. 2012
The Projection Analysis of NMR Chemical Shifts Reveals Extended EPAC Autoinhibition Determinants. 102:630-639. 2012
Stoichiometry and Affinity of the Human Serum Albumin-Alzheimer's Aβ Peptide Interactions. 100:183-192. 2011
Squeezing and Detachment of Living Cells. 99:3555-3562. 2010
High Mobility of Bicoid Captured by Fluorescence Correlation Spectroscopy: Implication for the Rapid Establishment of Its Gradient. 99:L33-L35. 2010
Individual Cell Movement, Asymmetric Colony Expansion, Rho-Associated Kinase, and E-Cadherin Impact the Clonogenicity of Human Embryonic Stem Cells. 98:2442-2451. 2010
Human Serum Albumin Inhibits Aβ Fibrillization through a “Monomer-Competitor” Mechanism. 97:2585-2594. 2009
Spatial Distribution and Mobility of the Ran GTPase in Live Interphase Cells. 97:2164-2178. 2009
Anomalous Diffusion Of Lipid Atoms And Molecules In Phospholipid Bilayers: A Combined Molecular Dynamics And Theoretical Study. 96:354a-354a. 2009
Cooperative long range protein-protein dynamics in Purple Membrane. 96:378a-378a. 2009
Subdiffusion And Diffusion Of Lipid Atoms And Molecules: Relating The Dynamics Of Lipids To Neutron Scattering Experiments. 96:198a-198a. 2009
Lipid Bilayer Structure Determined by the Simultaneous Analysis of Neutron and X-Ray Scattering Data. 95:2356-2367. 2008
Short-Range Order and Collective Dynamics of DMPC Bilayers: A Comparison between Molecular Dynamics Simulations, X-Ray, and Neutron Scattering Experiments. 93:3156-3168. 2007
Sodium Channels: Ionic Model of Slow Inactivation and State-Dependent Drug Binding. 93:1557-1570. 2007
Zero Mode Waveguides for Single-Molecule Spectroscopy on Lipid Membranes. 90:3288-3299. 2006
Local Structural Preferences and Dynamics Restrictions in the Urea-Denatured State of SUMO-1: NMR Characterization. 90:2498-2509. 2006
Anomalous Diffusion of Proteins Due to Molecular Crowding. 89:2960-2971. 2005
KvAP-Based Model of the Pore Region of Shaker Potassium Channel Is Consistent with Cadmium- and Ligand-Binding Experiments. 89:1020-1029. 2005
Two-Photon Activation and Excitation Properties of PA-GFP in the 720–920-nm Region. 89:1346-1352. 2005
Micrometer-Sized Supported Lipid Bilayer Arrays for Bacterial Toxin Binding Studies through Total Internal Reflection Fluorescence Microscopy. 89:296-305. 2005
Comprehensive phase diagrams of DMPC/DHPC bicelle mixtures. 88:237A-237A. 2005
Modeling P-Loops Domain of Sodium Channel: Homology with Potassium Channels and Interaction with Ligands. 88:184-197. 2005
In Silico Activation of KcsA K+ Channel by Lateral Forces Applied to the C-Termini of Inner Helices. 87:1526-1536. 2004
Reconstituted Fusion Pore. 85:2035-2043. 2003
938.1-Pos Board # 190.1 – In Vitro and In Vivo Motilities of Nuclear Transport Cargos. 84:3489-3489. 2003
Fluorescence Correlation Spectroscopy Close to a Fluctuating Membrane. 84:2005-2020. 2003
Structure and Composition of the Fusion Pore. 84:1337-1343. 2003
Shear Flow-Induced Detachment Kinetics of Dictyostelium discoideum Cells from Solid Substrate. 82:2383-2395. 2002
Osmotically Induced Shape Changes of Large Unilamellar Vesicles Measured by Dynamic Light Scattering. 81:2716-2728. 2001
Orientation and Effects of Mastoparan X on Phospholipid Bicelles. 80:280-293. 2001
Electrostatic Control of Phospholipid Polymorphism. 79:3193-3200. 2000
Chloride Channels of Glycine and GABA Receptors with Blockers: Monte Carlo Minimization and Structure-Activity Relationships. 78:1786-1803. 2000
Intersegment Hydrogen Bonds as Possible Structural Determinants of the N/Q/R Site in Glutamate Receptors. 77:1914-1926. 1999
Unfolding of Acrylodan-Labeled Human Serum Albumin Probed by Steady-State and Time-Resolved Fluorescence Methods. 75:1084-1096. 1998
Identification of the Ice-Binding Surface on a Type III Antifreeze Protein with a “Flatness Function” Algorithm. 74:2142-2151. 1998
Kinked-Helices Model of the Nicotinic Acetylcholine Receptor Ion Channel and Its Complexes with Blockers: Simulation by the Monte Carlo Minimization Method. 74:242-255. 1998
Optical changes in unilamellar vesicles experiencing osmotic stress. 71:2701-2715. 1996
Structural model of a synthetic Ca2+ channel with bound Ca2+ ions and dihydropyridine ligand. 70:22-37. 1996
Sedimentation Analysis of DNA from Irradiated and Unirradiated L Cells. 12:369-383. 1972
Actinomycin D. 9:1427-1445. 1969

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