selected scholarly activity
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chapters
- Chapter 131 Diseases of Platelet Number Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura. 1944-1954. 2018
- Diseases of Platelet Number. 1944-1954. 2018
- Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura. 1944-1954. 2017
- Management of immune‐mediated thrombocytopenia. 245-264. 2016
- Acquired hemolytic anemia. 157-172. 2011
- Acquired hemolytic anemia. 157-172. 2011
- CHAPTER 10 Acquired hemolytic anemia. 157-172. 2011
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conferences
- ANTIBODIES IN HITT AND VITT. American Journal of Hematology. E77-E77. 2023
- Circulating Autoantibodies in Post-Acute Sequelae of COVID-19. American Journal of Respiratory and Critical Care Medicine. 2022
- Elevation of Platelet Factor 4 in Systemic Sclerosis. Journal of Rheumatology. 1053-1053. 2020
- Pathogenic Antibodies in Heparin-Induced Thrombocytopenia Specifically Target an Immunodominant Region on Platelet Factor 4. Blood. 219-219. 2019
- Urgent Management of Bleeding in Immune Thrombocytopenia: Towards a Standardized Protocol in the Emergency Department. Blood. 3517-3517. 2018
- IMPROVING LABORATORY TESTING FOR HEPARIN INDUCED THROMBOCYTOPENIA. American Journal of Hematology. E47-E48. 2018
- Autoantibodies to thrombopoietin and the thrombopoietin receptor in patients with immune thrombocytopenia. Blood. 234-241. 2018
- Emergency Management of Patients with Immune Thrombocytopenia and Severe Bleeding. Blood. 2017
- Performance Characteristics of a Novel Platelet Viability Assay for Heparin-Induced Thrombocytopenia. Blood. 2017
- The Identification of the Amino Acids on Platelet Factor 4 That Bind Pathogenic Antibodies in Heparin-Induced Thrombocytopenia. Blood. 2017
- Megakaryocyte Apoptosis in the Bone Marrow of Patients with Immune Thrombocytopenia. Blood. 1379-1379. 2016
- Rivaroxaban for Treatment of Suspected or Confirmed Heparin-Induced Thrombocytopenia Study. Blood. 3468-3468. 2015
- The Mcmaster ITP Registry: Assessing the Prevalence, Clinical and Laboratory Features of Immune Thrombocytopenia. Blood. 5008-5008. 2014
- lLow Level Platelet-Activating Antibodies in Patients Suspected of Having Heparin-Induced Thrombocytopenia but Testing Negative in the "Gold Standard" Functional Test. Blood. 2014
- Persistent Impairments in Humoral and Cellular Immunity in Patients with Immune Thrombocytopenia Treated with Rituximab: A Sub-Study of a Randomized Controlled Trial. Blood. 2012
- Persistent Impairments in Humoral and Cellular Immunity in Patients with Immune Thrombocytopenia Treated with Rituximab: A Sub-Study of a Randomized Controlled Trial. Blood. 492-492. 2012
- Autoantibodies in Patients with ITP Do Not Bind to Patient-Specific Epitopes on Platelet Glycoproteins. Blood. 1175-1175. 2008
- The Efficacy of H. pylori Eradication Therapy in H. pylori-Infected and Uninfected Patients with Immune Thrombocytopenic Purpura: A Systematic Review. Blood. 1170-1170. 2008
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journal articles
- Reassuring humoral and cellular immune responses to SARS-CoV-2 vaccination in participants with systemic sclerosis.. Immunology Letters. 270:106929. 2024
- Bleeding self‐assessments by patients with immune thrombocytopenia (ITP): An agreement study. American Journal of Hematology. 99:1184-1186. 2024
- Vaccine-Induced Immune Thrombotic Thrombocytopenia: Clinicopathologic Features and New Perspectives on Anti-PF4 Antibody-Mediated Disorders. Journal of Clinical Medicine. 13:1012-1012. 2024
- Evaluation of laboratory testing parameters for vaccine-induced immune thrombotic thrombocytopenia and their implications for diagnosis. Journal of Thrombosis and Haemostasis. 22:304-306. 2024
- Antibodies against platelet factor 4 and the risk of cerebral venous sinus thrombosis in patients with vaccine-induced immune thrombotic thrombocytopenia. Journal of Thrombosis and Haemostasis. 21:2833-2843. 2023
- Investigation of anti-PF4 versus anti-PF4/heparin reactivity using fluid-phase enzyme immunoassay for 4 anti-PF4 disorders: classic heparin-induced thrombocytopenia (HIT), autoimmune HIT, vaccine-induced immune thrombotic thrombocytopenia, and spontaneous HIT. Journal of Thrombosis and Haemostasis. 21:2268-2276. 2023
- Structural characterization of a pathogenic antibody underlying vaccine-induced immune thrombotic thrombocytopenia (VITT). bioRxiv. 4:2023.05.28.542636. 2023
- Unique features of vaccine-induced immune thrombotic thrombocytopenia; a new anti-platelet factor 4 antibody-mediated disorder. International Journal of Hematology. 117:341-348. 2023
- Molecular architecture and platelet-activating properties of small immune complexes assembled on intact heparin and their possible involvement in heparin-induced thrombocytopenia. bioRxiv. 4:2023.02.11.528150. 2023
- Proceedings of the immune thrombocytopenia summit: new concepts in mechanisms, diagnosis, and management. Research and Practice in Thrombosis and Haemostasis. 7:100097-100097. 2023
- Characteristics of VITT antibodies in patients vaccinated with Ad26.COV2.S. Blood Advances. 7:246-250. 2023
- Circulating anti-nuclear autoantibodies in COVID-19 survivors predict long-COVID symptoms. European Respiratory Journal. 61:2200970-2200970. 2023
- Comparison of three dosing intervals for the primary vaccination of the SARS-CoV-2 mRNA Vaccine (BNT162b2) on magnitude, neutralization capacity and durability of the humoral immune response in health care workers: A prospective cohort study. PLoS ONE. 18:e0281673-e0281673. 2023
- Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination. Journal of Immunology. 209:1892-1905. 2022
- Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination.. Journal of Immunology. 209:1892-1905. 2022
- Longitudinal Characteristics of Anti-Platelet Factor 4 Immunoglobulin G in Vaccine-Induced Immune Thrombotic Thrombocytopenia. Blood. 140:5640-5641. 2022
- Understanding thrombosis with thrombocytopenia syndrome after COVID-19 vaccination. npj Vaccines. 7:141. 2022
- Clinical and laboratory predictors of fetal and neonatal alloimmune thrombocytopenia. Transfusion. 62:2213-2222. 2022
- Continuing Medical Education. Transfusion. 62:2212-2212. 2022
- Vaccine-induced immune thrombotic thrombocytopenia after COVID-19 vaccination: Description of a series of 39 cases in Brazil. Vaccine. 40:4788-4795. 2022
- The clinical and laboratory diagnosis of vaccine-induced immune thrombotic thrombocytopenia. Blood Advances. 6:4228-4235. 2022
- SARS-CoV-2 spike-dependent platelet activation in COVID-19 vaccine-induced thrombocytopenia. Blood Advances. 6:2250-2253. 2022
- Treatment of vaccine-induced immune thrombotic thrombocytopenia (VITT). Seminars in Hematology. 59:89-96. 2022
- Antibody Responses to Third-Dose mRNA Vaccines in Nursing Home and Assisted Living Residents. Journal of the American Medical Directors Association. 23:444-446. 2022
- Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial. Nature Medicine. 28:212-212. 2022
- Multicentre evaluation of 5B9, a monoclonal anti‐PF4/heparin IgG mimicking human HIT antibodies, as an internal quality control in HIT functional assays: Communication from the ISTH SSC Subcommittee on Platelet Immunology. Journal of Thrombosis and Haemostasis. 20:252-259. 2022
- Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19. Nature Medicine. 28:53-58. 2022
- T cell–mediated autoimmunity in immune thrombocytopenia. European Journal of Haematology. 108:18-27. 2022
- The COVID Complex: A Review of Platelet Activation and Immune Complexes in COVID-19. Frontiers in Immunology. 13:807934. 2022
- Vaccine-induced immune thrombotic thrombocytopenia: Updates in pathobiology and diagnosis. Frontiers in Cardiovascular Medicine. 9:1040196. 2022
- Antibody Responses to 3rd Dose mRNA Vaccines in Nursing Home and Assisted Living Residents 2021
- Antibody Responses 3-5 Months Post-Vaccination with mRNA-1273 or BNT163b2 in Nursing Home Residents. Journal of the American Medical Directors Association. 22:2512-2514. 2021
- Lessons from vaccine-induced immune thrombotic thrombocytopenia. Nature Reviews Immunology. 21:753-755. 2021
- Venous Thromboembolism and Mild Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination. Thrombosis and Haemostasis. 121:1677-1680. 2021
- Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections. Viruses. 13:2239-2239. 2021
- Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial. Nature Medicine. 27:2012-2024. 2021
- Platelet variability index: a measure of platelet count fluctuations in patients with immune thrombocytopenia. Blood Advances. 5:4256-4264. 2021
- Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia. Nature. 596:565-569. 2021
- Adjunct Immune Globulin for Vaccine-Induced Immune Thrombotic Thrombocytopenia. New England Journal of Medicine. 385:720-728. 2021
- Antibody Responses 3-5 Months Post-Vaccination with mRNA-1273 or BNT163b2 in Nursing Home Residents 2021
- The SSC platelet immunology register of VITT and VIITP: Toward standardization of laboratory and clinical parameters. Journal of Thrombosis and Haemostasis. 19:2094-2095. 2021
- Performance characteristics of platelet autoantibody testing for the diagnosis of immune thrombocytopenia using strict clinical criteria. British Journal of Haematology. 194:439-443. 2021
- Recommendations for the clinical and laboratory diagnosis of VITT against COVID‐19: Communication from the ISTH SSC Subcommittee on Platelet Immunology. Journal of Thrombosis and Haemostasis. 19:1585-1588. 2021
- Platelet‐activating immune complexes identified in critically ill COVID‐19 patients suspected of heparin‐induced thrombocytopenia. Journal of Thrombosis and Haemostasis. 19:1342-1347. 2021
- Characteristics of Anti-SARS-CoV-2 Antibodies in Recovered COVID-19 Subjects. Viruses. 13:697-697. 2021
- A comparative study of platelet factor 4‐enhanced platelet activation assays for the diagnosis of heparin‐induced thrombocytopenia. Journal of Thrombosis and Haemostasis. 19:1096-1102. 2021
- Dupilumab, severe asthma airway responses, and SARS‐CoV‐2 serology. Acta Allergologica. 76:957-958. 2021
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Serotonin‐release assay‐positive but platelet factor 4‐dependent enzyme‐immunoassay negative:
HIT or notHIT ?. American Journal of Hematology. 96:320-329. 2021 - Platelet Factor 4 Interactions with Short Heparin Oligomers: Implications for Folding and Assembly. Biophysical Journal. 119:1371-1379. 2020
- The mega-importance of de novo lipogenesis in platelet production. Nature Metabolism. 2:999-1000. 2020
- The role of fluid-phase immune complexes in the pathogenesis of heparin-induced thrombocytopenia. Thrombosis Research. 194:135-141. 2020
- High‐dose IVIG plus cangrelor platelet “anesthesia” during urgent heparin‐CPB in a patient with recent SRA‐negative HIT‐thrombosis with persisting platelet‐activating antibodies. Research and Practice in Thrombosis and Haemostasis. 4:1060-1064. 2020
- Platelet factor 4 inhibits ADAMTS13 activity and regulates the multimeric distribution of von Willebrand factor. British Journal of Haematology. 190:594-598. 2020
- Platelet autoantibodies in the bone marrow of patients with immune thrombocytopenia. Blood Advances. 4:2962-2966. 2020
- Management of major bleeds in patients with immune thrombocytopenia. Journal of Thrombosis and Haemostasis. 18:1783-1790. 2020
- Combination of two complementary automated rapid assays for diagnosis of heparin‐induced thrombocytopenia (HIT). Journal of Thrombosis and Haemostasis. 18:1435-1446. 2020
- Increased cytotoxic potential of CD8+ T cells in immune thrombocytopenia. British Journal of Haematology. 188:e72-e76. 2020
- Serotonin‐release assay‐negative heparin‐induced thrombocytopenia. American Journal of Hematology. 95:38-47. 2020
- A platelet viability assay (PVA) for the diagnosis of heparin-induced thrombocytopenia. Platelets. 30:1017-1021. 2019
- Corrigendum. Journal of Thrombosis and Haemostasis. 17:1578-1578. 2019
- Timeline of heparin‐induced thrombocytopenia seroconversion in serial plasma samples tested using an automated latex immunoturbidimetric assay. International Journal of Laboratory Hematology. 41:493-502. 2019
- The sensitivity and specificity of platelet autoantibody testing in immune thrombocytopenia: a systematic review and meta‐analysis of a diagnostic test. Journal of Thrombosis and Haemostasis. 17:787-794. 2019
- An international external quality assessment for laboratory diagnosis of heparin‐induced thrombocytopenia. Journal of Thrombosis and Haemostasis. 17:525-531. 2019
- Characterization of platelet factor 4 amino acids that bind pathogenic antibodies in heparin‐induced thrombocytopenia. Journal of Thrombosis and Haemostasis. 17:389-399. 2019
- Fluid-Phase Immune Complexes Can Assemble and Activate Platelets in Heparin-Induced Thrombocytopenia. Blood. 132:3746-3746. 2018
- Megakaryocyte apoptosis in immune thrombocytopenia. Platelets. 29:729-732. 2018
- High sensitivity and specificity of an automated IgG-specific chemiluminescence immunoassay for diagnosis of HIT. Blood. 132:1345-1349. 2018
- Cellular immune responses to platelet factor 4 and heparin complexes in patients with heparin‐induced thrombocytopenia. Journal of Thrombosis and Haemostasis. 16:1402-1412. 2018
- Platelet-Activating Antibodies Are Detectable at the Earliest Onset of Heparin-Induced Thrombocytopenia, With Implications for the Operating Characteristics of the Serotonin-Release Assay. Chest. 153:1396-1404. 2018
- Bacterial neuraminidase‐mediated erythrocyte desialylation provokes cell surface aminophospholipid exposure. European Journal of Haematology. 100:502-510. 2018
- The Use of Anticoagulation in Patients With Thrombocytopenia. Blood. 15. 2018
- Development of a high-yield expression and purification system for platelet factor 4. Platelets. 29:249-256. 2018
- Statins for high cholesterol … and for low platelets?. Blood. 131:1159-1161. 2018
- Misdiagnosis of primary immune thrombocytopenia and frequency of bleeding: lessons from the McMaster ITP Registry. Blood Advances. 1:2414-2420. 2017
- The effect of rituximab on anti‐platelet autoantibody levels in patients with immune thrombocytopenia. British Journal of Haematology. 178:302-307. 2017
- Performance characteristics of an automated latex immunoturbidimetric assay [HemosIL ® HIT-Ab (PF4-H) ] for the diagnosis of immune heparin-induced thrombocytopenia. Thrombosis Research. 153:108-117. 2017
- The unique immunological features of heparin‐induced thrombocytopenia. British Journal of Haematology. 177:198-207. 2017
- Thrombotic microangiopathies: a general approach to diagnosis and management. CANADIAN MEDICAL ASSOCIATION JOURNAL. 189:E153-E159. 2017
- Difficulties in establishing the diagnosis of immune thrombocytopenia: An agreement study. American Journal of Hematology. 91:E327-E329. 2016
- Rivaroxaban for treatment of suspected or confirmed heparin‐induced thrombocytopenia study. Journal of Thrombosis and Haemostasis. 14:1206-1210. 2016
- Producing megakaryocytes from a human peripheral blood source. Transfusion. 56:1066-1074. 2016
- Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin. Journal of Cellular and Molecular Medicine. 20:710-720. 2016
- Antibody binding to megakaryocytes in vivo in patients with immune thrombocytopenia. European Journal of Haematology. 95:532-537. 2015
- Distinguishing between anti–platelet factor 4/heparin antibodies that can and cannot cause heparin‐induced thrombocytopenia. Journal of Thrombosis and Haemostasis. 13:1900-1907. 2015
- Pitfalls in the diagnosis of heparin‐Induced thrombocytopenia: A 6‐year experience from a reference laboratory. American Journal of Hematology. 90:629-633. 2015
- The platelet serotonin‐release assay. American Journal of Hematology. 90:564-572. 2015
- Severe bleeding events in adults and children with primary immune thrombocytopenia: a systematic review. Journal of Thrombosis and Haemostasis. 13:457-464. 2015
- Low Level Platelet-Activating Antibodies in Patients Suspected of Having Heparin-Induced Thrombocytopenia but Testing Negative in the ”Gold Standard” Functional Test. Blood. 124:2757-2757. 2014
- Novel treatments for immune thrombocytopenia. Presse Medicale. 43:e87-e95. 2014
- Sustained remissions of immune thrombocytopenia associated with the use of thrombopoietin receptor agonists. Transfusion. 53:2807-2812. 2013
- The effect of rituximab on vaccine responses in patients with immune thrombocytopenia. Blood. 122:1946-1953. 2013
- Approach to the Diagnosis and Management of Drug-Induced Immune Thrombocytopenia. Transfusion Medicine Reviews. 27:137-145. 2013
- FcγRIIa proteolysis as a diagnostic biomarker for heparin-induced thrombocytopenia. Journal of Thrombosis and Haemostasis. 11:1146-1153. 2013
- A blinded study of bone marrow examinations in patients with primary immune thrombocytopenia. European Journal of Haematology. 90:121-126. 2013
- A systematic evaluation of laboratory testing for drug‐induced immune thrombocytopenia. Journal of Thrombosis and Haemostasis. 11:169-176. 2013
- A prospective study measuring the development of antibodies against platelet factor 4–heparin in healthy males after exposure to heparins. Journal of Thrombosis and Haemostasis. 10:1446-1449. 2012
- Piecing Together the Humoral and Cellular Mechanisms of Immune Thrombocytopenia. Seminars in Thrombosis and Hemostasis. 37:631-639. 2011
- β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents. Journal of Antibiotics. 64:483-487. 2011
- Identification and Characterization of New Inhibitors of Fungal Homoserine Kinase. ChemBioChem. 12:1179-1182. 2011
- The association between platelet activation and FcγRIIa proteolysis. Journal of Thrombosis and Haemostasis. 9:885-887. 2011
- A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor. Nature Chemical Biology. 6:327-329. 2010
- Combination immunosuppressant therapy for patients with chronic refractory immune thrombocytopenic purpura. Blood. 115:29-31. 2010
- New treatments for idiopathic thrombocytopenic purpura: rethinking old hypotheses. Expert Opinion on Investigational Drugs. 18:805-819. 2009
- Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic review. Haematologica. 94:850-856. 2009
- Autoantibodies in Patients with ITP Do Not Bind to Patient-Specific Epitopes on Platelet Glycoproteins.. Blood. 112:3427-3427. 2008
- The Efficacy of H. pylori Eradication Therapy in H. pylori-Infected and Uninfected Patients with Immune Thrombocytopenic Purpura: A Systematic Review.. Blood. 112:3413-3413. 2008
- Role of Homoserine Transacetylase as a New Target for Antifungal Agents. Antimicrobial Agents and Chemotherapy. 51:1731-1736. 2007
- Crystal Structure of Homoserine Transacetylase from Haemophilus influenzae Reveals a New Family of α/β-Hydrolases,. Biochemistry. 44:15768-15773. 2005
- Catalytic Mechanism of Fungal Homoserine Transacetylase. Biochemistry. 44:13560-13566. 2005
- Allelopathic effects of Eucalyptus citriodora on growth, nodulation and AM colonization of Vigna radiata (L) Wilczek. Allelopathy Journal. 15:237-246. 2005
- New phenolic inhibitors of yeast homoserine dehydrogenase. Bioorganic and Medicinal Chemistry. 12:3825-3830. 2004
- Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine. Bioorganic and Medicinal Chemistry. 12:807-815. 2004
- One-pot chemoenzymatic preparation of coenzyme A analogues. Analytical Biochemistry. 324:100-105. 2004
- Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor. Chemistry and Biology. 10:967-973. 2003
- Second-Line Therapy for Immune Thrombocytopenia: Real-World Experience in Canada. Canadian Journal of General Internal Medicine. 15:28-35.
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preprints