selected scholarly activity
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conferences
- Understanding the molecular mechanism of bacterial translesion DNA synthesis pathways. Environmental and Molecular Mutagenesis. 53-54. 2023
- Strategies to find low-occupancy ligands in a protein–peptide crystal. Acta Crystallographica Section A: Foundations of Crystallography. a107-a107. 2023
- Multiple Roles Of The Mycobacterium tuberculosis Ku C-terminus In Repairing DNA Double-Strand Breaks. Environmental and Molecular Mutagenesis. 145-146. 2022
- Unraveling the Role of a DNA Helicase in Bacterial DNA Double-Strand Break Repair. Environmental and Molecular Mutagenesis. 134-134. 2022
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journal articles
- Poly ADP-ribose signaling is dysregulated in Huntington disease.. Proceedings of the National Academy of Sciences of the United States of America. 121:e2318098121. 2024
- CSB and SMARCAL1 compete for RPA32 at stalled forks and differentially control the fate of stalled forks in BRCA2-deficient cells. Nucleic Acids Research (NAR). 52:5067-5087. 2024
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Myxococcus xanthus translesion
DNA synthesis proteinImuA is anATPase enhanced byDNA . Protein Science. 33:e4981. 2024 - Structure-specific roles for PolG2–DNA complexes in maintenance and replication of mitochondrial DNA. Nucleic Acids Research (NAR). 51:9716-9732. 2023
- The Mycobacterium tuberculosis Ku C-terminus is a multi-purpose arm for binding DNA and LigD and stimulating ligation. Nucleic Acids Research (NAR). 50:11040-11057. 2022
- Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics. Cell Chemical Biology. 28:1394-1406.e10. 2021
- Interplay between Nucleoid-Associated Proteins and Transcription Factors in Controlling Specialized Metabolism in Streptomyces. mBio. 12:e0107721. 2021
- LigD: A Structural Guide to the Multi-Tool of Bacterial Non-Homologous End Joining. Frontiers in Molecular Biosciences. 8:787709. 2021
- Stepwise Reversion of Multiply Mutated Recombinant Antitrypsin Reveals a Selective Inhibitor of Coagulation Factor XIa as Active as the M358R Variant. Frontiers in Cardiovascular Medicine. 8:647405. 2021
- Correction: Ctp1 protein–DNA filaments promote DNA bridging and DNA double-strand break repair.. Journal of Biological Chemistry. 295:896-896. 2020
- Correction: Ctp1 protein–DNA filaments promote DNA bridging and DNA double-strand break repair.. Journal of Biological Chemistry. 295:896-896. 2020
- Ctp1 protein–DNA filaments promote DNA bridging and DNA double-strand break repair. Journal of Biological Chemistry. 294:3312-3320. 2019
- Regulatory control of DNA end resection by Sae2 phosphorylation. Nature Communications. 9:4016. 2018
- CtIP/Ctp1/Sae2, molecular form fit for function. DNA Repair. 56:109-117. 2017
- APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 114:304-309. 2017
- Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair. Nature Structural & Molecular Biology. 22:158-166. 2015
- Recognition and repair of chemically heterogeneous structures at DNA ends. Environmental and Molecular Mutagenesis. 56:1-21. 2015
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Structural–Functional Studies of Burkholderia cenocepacia
d -Glycero-β-d -manno-heptose 7-Phosphate Kinase (HldA) and Characterization of Inhibitors with Antibiotic Adjuvant and Antivirulence Properties. Journal of Medicinal Chemistry. 56:1405-1417. 2013 - A human XRCC4–XLF complex bridges DNA. Nucleic Acids Research (NAR). 40:1868-1878. 2012
- XRCC4's interaction with XLF is required for coding (but not signal) end joining. Nucleic Acids Research (NAR). 40:1684-1694. 2012
- Crystallization and preliminary X-ray diffraction analysis of the human XRCC4–XLF complex. Acta Crystallographica Section F: Structural Biology Communications. 67:1399-1402. 2011
- Structural and Biochemical Characterization of SrcA, a Multi-Cargo Type III Secretion Chaperone in Salmonella Required for Pathogenic Association with a Host. PLoS Pathogens. 6:e1000751-e1000751. 2010
- Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4. Molecular and Cellular Biology. 29:3163-3172. 2009
- Crystal Structure of Human XLF: A Twist in Nonhomologous DNA End-Joining. Molecular Cell. 28:1093-1101. 2007
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preprints
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theses