Germ-Line Mutation Concept

subject area of

• CDKN2AMutations in Multiple Primary Melanomas  Journal Articles
• A combined analysis of outcome following breast cancer: differences in survival based on BRCA1/BRCA2 mutation status and administration of adjuvant treatment  Journal Articles
• Air pollution induces heritable DNA mutations  Journal Articles
• An evaluation of germline mutations and reproductive impacts in fathead minnow (Pimephales promelas) exposed to contaminated sediment  Journal Articles
• Application of Breast Cancer Risk Prediction Models in Clinical Practice  Journal Articles
• Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study  Journal Articles
• Brief family history questionnaire to screen for Lynch syndrome in women with newly diagnosed non-serous, non-mucinous ovarian cancers  Journal Articles
• Canadian Recommendations for Germline Genetic Testing of Patients with Breast Cancer: A Call to Action.  Journal Articles
• Clinical effectiveness and safety of olaparib in BRCA-mutated, HER2-negative metastatic breast cancer in a real-world setting: final analysis of LUCY.  Journal Articles
• Colorectal cancer in adolescents and young adults: Defining a growing threat  Journal Articles
• Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS  Journal Articles
• Cowden Syndrome  Journal Articles
• Cyclin E expression in breast cancer: predicting germline BRCA1 mutations, prognosis and response to treatment  Journal Articles
• De novo mutations in CSNK2A1 are associated with neurodevelopmental abnormalities and dysmorphic features  Journal Articles
• Dental abnormalities in individuals with pathogenic germline variation in DICER1  Journal Articles
• Double heterozygosity for germline mutations in BRCA1 and p53 in a woman with early onset breast cancer  Journal Articles
• Factors affecting germline mutations in a hypervariable microsatellite: A comparative analysis of six species of swallows (Aves: Hirundinidae)  Journal Articles
• Fumarate Hydratase–deficient Renal Cell Carcinoma Is Strongly Correlated With Fumarate Hydratase Mutation and Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome  Journal Articles
• Gamma radiation-induced heritable mutations at repetitive DNA loci in out-bred mice  Journal Articles
• Gastrointestinal cancers and neurofibromatosis type 1 features in children with a germline homozygous MLH1 mutation  Journal Articles
• Genome-wide germline correlates of the epigenetic landscape of prostate cancer  Journal Articles
• Germline BRCA mutation carriers are more likely to undergo cytoreductive surgery for relapsed, platinum sensitive, ovarian cancer.  Journal Articles
• Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer  Journal Articles
• Germline HOXB13 p.Gly84Glu mutation and risk of colorectal cancer  Journal Articles
• Germline Mutations and Variants in the Succinate Dehydrogenase Genes in Cowden and Cowden-like Syndromes  Journal Articles
• Germline mutations in PTEN and SDHC in a woman with epithelial thyroid cancer and carotid paraganglioma  Journal Articles
• Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma  Journal Articles
• Germline variation in the insulin-like growth factor pathway and risk of Barrett’s esophagus and esophageal adenocarcinoma  Journal Articles
• Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity  Journal Articles
• Global issues and opportunities for optimized retinoblastoma care  Journal Articles
• Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer  Journal Articles
• Hamartomatous polyposis syndromes  Journal Articles
• Hormonal Contraception and Breast Cancer Risk for Carriers of Germline Mutations in BRCA1 and BRCA2.  Journal Articles
• Impact of germline BRCA1 mutations and overexpression of p53 on prognosis and response to treatment following breast carcinoma  Journal Articles
• Incidence of endometrial cancer in BRCA mutation carriers.  Journal Articles
• Induced minisatellite germline mutations in herring gulls (Larus argentatus) living near steel mills  Journal Articles
• Influence of a contaminated fish diet on germline expanded‐simple‐tandem‐repeat mutation frequency in mice  Journal Articles
• Is Uterine Papillary Serous Adenocarcinoma a Manifestation of the Hereditary Breast–Ovarian Cancer Syndrome?  Journal Articles
• Mainstream Model of Genetic Testing for Prostate Cancer at a Large Tertiary Cancer Centre  Journal Articles
• Mainstream Tobacco Smoke Causes Paternal Germ-Line DNA Mutation  Journal Articles
• Multiple Tumors in a Child with Germ-Line Mutations inTP53andPTEN  Journal Articles
• Parity, breastfeeding, and the risk of early-onset breast cancer in women with a BRCA1 pathogenic variant.  Journal Articles
• Pathogenic Germline Variants in 10,389 Adult Cancers  Journal Articles
• Pediatric patients with pheochromocytoma and paraganglioma should have routine preoperative genetic testing for common susceptibility genes in addition to imaging to detect extra-adrenal and metastatic tumors  Conferences
• Performance characteristics of a brief Family History Questionnaire to screen for Lynch syndrome in women with newly diagnosed endometrial cancer  Journal Articles
• Performance characteristics of screening strategies for Lynch syndrome in unselected women with newly diagnosed endometrial cancer who have undergone universal germline mutation testing  Journal Articles
• Practice guidelines for BRCA1/2 tumour testing in ovarian cancer  Journal Articles
• Prophylactic oophorectomy in Ontario.  Journal Articles
• Reduction of Particulate Air Pollution Lowers the Risk of Heritable Mutations in Mice  Journal Articles
• Risk factors for ovarian cancer and early-onset breast cancer in Mongolia.  Journal Articles
• Second rhabdoid tumor 8 years after treatment of atypical teratoid/rhabdoid tumor in a child with germline SMARCB1 mutation  Journal Articles
• Should platinum-based chemotherapy be preferred for germline BReast CAncer genes (BRCA) 1 and 2-mutated pancreatic ductal adenocarcinoma (PDAC) patients? A systematic review and meta-analysis  Journal Articles
• Synaptic, transcriptional and chromatin genes disrupted in autism  Journal Articles
• The Germline and Somatic Origins of Prostate Cancer Heterogeneity.  Journal Articles
• The impact of prophylactic salpingo-oophorectomy on menopausal symptoms and sexual function in women who carry a BRCA mutation  Journal Articles
• The incidence of pancreatic cancer in women with a BRCA1 or BRCA2 mutation.  Journal Articles
• The mutational landscape of human somatic and germline cells  Journal Articles