Journal article
Regulatory Evolution Drives Evasion of Host Inflammasomes by Salmonella Typhimurium
Abstract
Bacterial two-component regulatory systems (TCS) couple the detection of niche-specific cues with adaptive gene expression to optimize fitness. In Salmonella Typhimurium (STM), the SsrA-SsrB TCS regulates virulence genes needed for survival within host cells, yet the impact of this TCS on regulatory evolution in this pathogen remains incompletely understood. Here, we show that SsrB alters a transcriptional network controlling bacterial motility …
Authors
Ilyas B; Mulder DT; Little DJ; Elhenawy W; Banda MM; Pérez-Morales D; Tsai CN; Chau NYE; Bustamante VH; Coombes BK
Journal
Cell Reports, Vol. 25, No. 4, pp. 825–832.e5
Publisher
Elsevier
Publication Date
October 2018
DOI
10.1016/j.celrep.2018.09.078
ISSN
2639-1856