selected scholarly activity
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conferences
- A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium. 383828. 2018
- MICROBIAL PROTEASES INCREASE SENSITIVITY TO DIETARY ANTIGEN THROUGH PAR-2 SIGNALING. Gastroenterology. S491-S492. 2018
- A draft genome of Yersinia pestis from victims of the Black Death. American Journal of Physical Anthropology. 103-104. 2012
- Salmonella Typhimurium reprograms nucleotide metabolism for survival against host immunity
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journal articles
- A Nanocomposite Dynamic Covalent Cross-Linked Hydrogel Loaded with Fusidic Acid for Treating Antibiotic-Resistant Infected Wounds. ACS Applied Bio Materials. 7:1947-1957. 2024
- A187 PROPHYLACTIC PHAGE TREATMENT ENHANCES SUB-THERAPEUTIC EFFICACY OF BUDESONIDE AGAINST E. COLI DRIVEN COLITIS IN MICE COLONIZED WITH A DEFINED MICROBIOTA. Journal of the Canadian Association of Gastroenterology. 7:147-148. 2024
- Characterizing the Pathogenic Potential of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli. EcoSal Plus. 11:eesp00182022. 2023
- Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii. Nature Chemical Biology. 19:1342-1350. 2023
- Screening under infection-relevant conditions reveals chemical sensitivity in multidrug resistant invasive non-typhoidal Salmonella (iNTS). RSC Chemical Biology. 4:600-612. 2023
- Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus. Journal of Medicinal Chemistry. 66:9006-9022. 2023
- Correction for Popov et al., “Distinct Molecular Features of NleG Type 3 Secreted Effectors Allow for Different Roles during Citrobacter rodentium Infection in Mice”. Infection and Immunity. 91:e0009423. 2023
- A32 PHAGE TREATMENT DELAYS ONSET OF CROHN’S-ASSOCIATED E. COLI DRIVEN COLITIS IN MICE COLONIZED WITH A DEFINED MICROBIOTA. Journal of the Canadian Association of Gastroenterology. 6:17-18. 2023
- Distinct Molecular Features of NleG Type 3 Secreted Effectors Allow for Different Roles during Citrobacter rodentium Infection in Mice. Infection and Immunity. 91:e0050522. 2023
- Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria. ACS Infectious Diseases. 8:2187-2197. 2022
- A200 CROHN’S-ASSOCIATED E. COLI WORSEN COLITIS SEVERITY IN MICE COLONIZED WITH DEFINED MICROBIOTA. Journal of the Canadian Association of Gastroenterology. 5:85-86. 2022
- Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts. Nature Communications. 12:6664. 2021
- Low dietary fiber promotes enteric expansion of a Crohn’s disease-associated pathobiont independent of obesity. American Journal of Physiology - Endocrinology and Metabolism. 321:E338-E350. 2021
- Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis. PLoS Pathogens. 17:e1009532-e1009532. 2021
- High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli. Nature Communications. 12:2032. 2021
- Emergence of invasive Salmonella in Africa. Nature Microbiology. 6:273-274. 2021
- (p)ppGpp-Dependent Regulation of the Nucleotide Hydrolase PpnN Confers Complement Resistance in Salmonella enterica Serovar Typhimurium. Infection and Immunity. 89:e00639-e00620. 2021
- High-Throughput Chemical Screening for Inhibitors of Salmonella Pathogenicity Island 2. STAR Protocols. 1:100057-100057. 2020
- Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae. Cell Reports. 32:107927-107927. 2020
- Targeting Two-Component Systems Uncovers a Small-Molecule Inhibitor of Salmonella Virulence. Cell Chemical Biology. 27:793-805.e7. 2020
- Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling. Nature. 578:582-587. 2020
- Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens. Nature Microbiology. 5:93-101. 2020
- The Unique Lifestyle of Crohn's Disease-Associated Adherent-Invasive Escherichia coli. Journal of Molecular Biology. 431:2970-2981. 2019
- Complete Genome Sequence of Citrobacter rodentium Strain DBS100. Microbiology Resource Announcements. 8:e00421-e00419. 2019
- The Role of the Host in Driving Phenotypic Heterogeneity in Salmonella. Trends in Microbiology. 27:508-523. 2019
- Antibiotics Potentiate Adherent-InvasiveE. coliInfection and Expansion. Inflammatory Bowel Diseases. 25:711-721. 2019
- Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2. Nature Communications. 10:1198. 2019
- Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis. Science. 363:eaat4042. 2019
- Host-Specific Adaptive Diversification of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli. Cell Host and Microbe. 25:301-312.e5. 2019
- A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium. Nature Communications. 10:197. 2019
- Functional diversification of the NleG effector family in enterohemorrhagic Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 115:10004-10009. 2018
- Regulatory Evolution Drives Evasion of Host Inflammasomes by Salmonella Typhimurium. Cell Reports. 25:825-832.e5. 2018
- Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli. PLoS Pathogens. 14:e1007224-e1007224. 2018
- Su1168 - Microbial Proteases Increase Sensitivity to Dietary Antigen Through Par-2 Signaling. Gastroenterology. 154:s-491-s-492. 2018
- Correction: Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period. PLoS Pathogens. 14:e1007032-e1007032. 2018
- A polymicrobial view of disease potential in Crohn's-associated adherent-invasive E. coli. Gut Microbes. 9:166-174. 2018
- A118 EXPOSURE TO CROHN’S DISEASE-ASSOCIATED ADHERENT-INVASIVE E.COLI (AIEC) AT THE HEIGHT OF INFECTIOUS COLITIS IMPAIRS HOST-MEDIATED CLEARANCE OF AIEC. Journal of the Canadian Association of Gastroenterology. 1:208-208. 2018
- A19 BACTERIAL PROTEASES INCREASE SENSITIVITY TO DIETARY ANTIGEN THROUGH PAR-2 SIGNALING. Journal of the Canadian Association of Gastroenterology. 1:31-32. 2018
- A291 INVESTIGATING THE ROLE OF ANTIBIOTICS AND ADHERENT-INVASIVE E. COLI IN THE PATHOGENESIS OF CROHN’S DISEASE. Journal of the Canadian Association of Gastroenterology. 1:505-505. 2018
- Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics. Nature Communications. 9:458. 2018
- The transcriptional regulator SsrB is involved in a molecular switch controlling virulence lifestyles of Salmonella. PLoS Pathogens. 13:e1006497-e1006497. 2017
- Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4. Cell Metabolism. 25:1063-1074.e3. 2017
- Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance. Nature Microbiology. 2:17028. 2017
- Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome. Frontiers in Cellular and Infection Microbiology. 7:428. 2017
- Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period. PLoS Pathogens. 12:e1005907-e1005907. 2016
- Bacterial evolution: Making a host-adapted bacterium. Nature Microbiology. 1:16010. 2016
- Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae. ACS Infectious Diseases. 1:533-543. 2015
- A Highly Effective Component Vaccine against Nontyphoidal Salmonella enterica Infections. mBio. 6:e01421-e01415. 2015
- CXCL9 Contributes to Antimicrobial Protection of the Gut during Citrobacter rodentium Infection Independent of Chemokine-Receptor Signaling. PLoS Pathogens. 11:e1004648-e1004648. 2015
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Multiple histidines in the periplasmic domain of the
S almonella enterica sensor kinaseSsrA enhance signaling in response to extracellular acidification. Molecular Microbiology. 95:678-691. 2015 - Convergence of External Crohn’s Disease Risk Factors on Intestinal Bacteria. Frontiers in Immunology. 6:558. 2015
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Salmonella
Evades
d -Amino Acid Oxidase To Promote Infection in Neutrophils. mBio. 5:e01886. 2014 - Host Defense Peptide Resistance Contributes to Colonization and Maximal Intestinal Pathology by Crohn's Disease-Associated Adherent-Invasive Escherichia coli. Infection and Immunity. 82:3383-3393. 2014
- Identification of the Docking Site between a Type III Secretion System ATPase and a Chaperone for Effector Cargo. Journal of Biological Chemistry. 289:23734-23744. 2014
- Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance. Nature. 510:503-506. 2014
- The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA. BMC Microbiology. 13:221. 2013
- CD3−NK1.1+ cells aid in the early induction of a Th1 response to an attaching and effacing enteric pathogen. European Journal of Immunology. 43:2638-2649. 2013
- IL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium. Placenta. 34:765-774. 2013
- Mapping and Regulation of Genes within Salmonella Pathogenicity Island 12 That Contribute to In Vivo Fitness of Salmonella enterica Serovar Typhimurium. Infection and Immunity. 81:2394-2404. 2013
- Regulatory evolution at the host–pathogen interface. Canadian Journal of Microbiology. 59:365-367. 2013
- Cheats never prosper. Nature. 494:321-322. 2013
- Active modification of host inflammation bySalmonella. Gut Microbes. 4:140-145. 2013
- Persistent infection with Crohn’s disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis. Nature Communications. 4:1957. 2013
- Novel Repressor of Escherichia coli O157:H7 Motility Encoded in the Putative Fimbrial Cluster OI-1. Journal of Bacteriology. 194:5343-5352. 2012
- Type VI Secretion System-Associated Gene Clusters Contribute to Pathogenesis of Salmonella enterica Serovar Typhimurium. Infection and Immunity. 80:1996-2007. 2012
- Characterization of DalS, an ATP-binding Cassette Transporter for d-Alanine, and Its Role in Pathogenesis in Salmonella enterica. Journal of Biological Chemistry. 287:15242-15250. 2012
- GogB Is an Anti-Inflammatory Effector that Limits Tissue Damage during Salmonella Infection through Interaction with Human FBXO22 and Skp1. PLoS Pathogens. 8:e1002773-e1002773. 2012
- Erratum: A draft genome of Yersinia pestis from victims of the Black Death. Nature. 480:278-278. 2011
- The non-motile phenotype of Salmonella hha ydgT mutants is mediated through PefI-SrgD. BMC Microbiology. 11:141. 2011
- A draft genome of Yersinia pestis from victims of the Black Death. Nature. 478:506-510. 2011
- Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid ofYersinia pestisfrom victims of the Black Death. Proceedings of the National Academy of Sciences of the United States of America. 108:E746-E752. 2011
- Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease. Inflammatory Bowel Diseases. 17:1451-1463. 2011
- Quantitative Mass Spectrometry Catalogues Salmonella Pathogenicity Island-2 Effectors and Identifies Their Cognate Host Binding Partners. Journal of Biological Chemistry. 286:24023-24035. 2011
- Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nature Chemical Biology. 7:348-350. 2011
- Humanized mice forSalmonellatyphiinfection: new tools for an old problem. Virulence. 2:248-252. 2011
- Salmonella Phage ST64B Encodes a Member of the SseK/NleB Effector Family. PLoS ONE. 6:e17824-e17824. 2011
- Expression and secretion hierarchy in the nonflagellar type III secretion system. Future Microbiology. 6:193-202. 2011
- A Fresh Look at the Type III Secretion System: Two-Step Model of Effector Translocation in Pathogenic Bacteria. Frontiers in Microbiology. 2:113. 2011
- The Evolution of Virulence in Non-O157 Shiga Toxin-Producing Escherichia Coli. Frontiers in Microbiology. 2:90. 2011
- The evolution of virulence in non-O157 shiga toxin-producing Escherichia coli. Frontiers in Microbiology. 2. 2011
- Transcriptional Priming of Salmonella Pathogenicity Island-2 Precedes Cellular Invasion. PLoS ONE. 6:e21648-e21648. 2011
- Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes. BMC Genomics. 11:667. 2010
- A General Approach to the Construction of Structure‐Switching Reporters from RNA Aptamers. Angewandte Chemie International Edition. 49:7938-7942. 2010
- A General Approach to the Construction of Structure‐Switching Reporters from RNA Aptamers. Angewandte Chemie International Edition. 122:8110-8114. 2010
- NleG Type 3 Effectors from Enterohaemorrhagic Escherichia coli Are U-Box E3 Ubiquitin Ligases. PLoS Pathogens. 6:e1000960-e1000960. 2010
- Identification of the Regulatory Logic Controlling Salmonella Pathoadaptation by the SsrA-SsrB Two-Component System. PLoS Genetics. 6:e1000875-e1000875. 2010
- Structural and Biochemical Characterization of SrcA, a Multi-Cargo Type III Secretion Chaperone in Salmonella Required for Pathogenic Association with a Host. PLoS Pathogens. 6:e1000751-e1000751. 2010
- A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication. BMC Microbiology. 9:218. 2009
- Salmonella entericaSerovar Typhimurium Exploits Toll-Like Receptor Signaling during the Host-Pathogen Interaction. Infection and Immunity. 77:4750-4760. 2009
- Pathogenic adaptation of intracellular bacteria by rewiring a cis -regulatory input function. Proceedings of the National Academy of Sciences of the United States of America. 106:3982-3987. 2009
- Salmonella -Containing Vacuoles Display Centrifugal Movement Associated with Cell-to-Cell Transfer in Epithelial Cells. Infection and Immunity. 77:996-1007. 2009
- Type III secretion systems in symbiotic adaptation of pathogenic and non-pathogenic bacteria. Trends in Microbiology. 17:89-94. 2009
- Interleukin-15 and NK1.1+Cells Provide Innate Protection against AcuteSalmonella entericaSerovar Typhimurium Infection in the Gut and in Systemic Tissues. Infection and Immunity. 77:214-222. 2009
- Role of RpoS in the Virulence of Citrobacter rodentium. Infection and Immunity. 77:501-507. 2009
- RpoE fine tunes expression of a subset of SsrB-regulated virulence factors in Salmonella enterica serovar Typhimurium. BMC Microbiology. 9:45-45. 2009
- FimH Adhesin of Type 1 Fimbriae Is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling. PLoS Pathogens. 4:e1000233-e1000233. 2008
- Subinhibitory concentrations of tetracycline affect virulence gene expression in a multi-resistant Salmonella enterica subsp. enterica serovar Typhimurium DT104. Microbes and Infection. 10:901-907. 2008
- Salmonella enterica Serovar Senftenberg Human Clinical Isolates Lacking SPI-1. Journal of Clinical Microbiology. 46:1330-1336. 2008
- Molecular Analysis as an Aid To Assess the Public Health Risk of Non-O157 Shiga Toxin-Producing Escherichia coli Strains. Applied and Environmental Microbiology. 74:2153-2160. 2008
- Oral infection of mice with Salmonella entericaserovar Typhimurium causes meningitis and infection of the brain. BMC Infectious Diseases. 7:65. 2007
- Thermosensing Coordinates a Cis-regulatory Module for Transcriptional Activation of the Intracellular Virulence System in Salmonella enterica Serovar Typhimurium. Journal of Biological Chemistry. 282:34077-34084. 2007
- Repression of Intracellular Virulence Factors in Salmonella by the Hha and YdgT Nucleoid-Associated Proteins. Journal of Bacteriology. 189:3669-3673. 2007
- Virulence Is Positively Selected by Transmission Success between Mammalian Hosts. Current Biology. 17:783-788. 2007
- Citrobacter rodentium virulence in mice associates with bacterial load and the type III effector NleE. Microbes and Infection. 9:400-407. 2007
- Targeting Bacterial Secretion Systems: Benefits of Disarmament in the Microcosm. Infectious Disorders - Drug Targets. 7:19-27. 2007
- SseL Is a Salmonella -Specific Translocated Effector Integrated into the SsrB-Controlled Salmonella Pathogenicity Island 2 Type III Secretion System. Infection and Immunity. 75:574-580. 2007
- Bacterial Genetic Determinants of Non‐O157 STEC Outbreaks and Hemolytic‐Uremic Syndrome after Infection. Journal of Infectious Diseases. 194:819-827. 2006
- Mutational analysis of Salmonella translocated effector members SifA and SopD2 reveals domains implicated in translocation, subcellular localization and function. Microbiology (United Kingdom). 152:2323-2343. 2006
- Crossing the Line: Selection and Evolution of Virulence Traits. PLoS Pathogens. 2:e42-e42. 2006
- Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid. Proceedings of the National Academy of Sciences of the United States of America. 102:17460-17465. 2005
- Analysis of the Contribution of Salmonella Pathogenicity Islands 1 and 2 to Enteric Disease Progression Using a Novel Bovine Ileal Loop Model and a Murine Model of Infectious Enterocolitis. Infection and Immunity. 73:7161-7169. 2005
- Salmonella Pathogenicity Island 2 Is Expressed Prior to Penetrating the Intestine. PLoS Pathogens. 1:e32-e32. 2005
- Genetic and Molecular Analysis of GogB, a Phage-encoded Type III-secreted Substrate in Salmonella enterica Serovar Typhimurium with Autonomous Expression from its Associated Phage. Journal of Molecular Biology. 348:817-830. 2005
- Insertion of the bacterial type III translocon: not your average needle stick. Trends in Microbiology. 13:92-95. 2005
- Expression and Secretion of Salmonella Pathogenicity Island-2 Virulence Genes in Response to Acidification Exhibit Differential Requirements of a Functional Type III Secretion Apparatus and SsaL. Journal of Biological Chemistry. 279:49804-49815. 2004
- Evasive Maneuvers by Secreted Bacterial Proteins to Avoid Innate Immune Responses. Current Biology. 14:R856-R867. 2004
- Interpreting the Host-Pathogen Dialogue Through Microarrays. Advances in Applied Microbiology. 54:291-331. 2004
- SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells. Microbes and Infection. 5:561-570. 2003
- Strategic Targeting of Essential Host-pathogen Interactions in Chlamydial Disease. Infectious Disorders - Drug Targets. 2:201-216. 2002
- Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells. Cellular Microbiology. 4:447-460. 2002
- Chlamydia pneumoniaeInfection of Endothelial Cells Induces Transcriptional Activation of Platelet‐Derived Growth Factor–B: A Potential Link to Intimal Thickening in a Rabbit Model of Atherosclerosis. Journal of Infectious Diseases. 185:1621-1630. 2002
- Dendritic cell discoveries provide new insight into the cellular immunobiology of DNA vaccines. Immunology Letters. 78:103-111. 2001
- Chlamydia pneumoniae and atherosclerosis: does the evidence support a causal or contributory role?. FEMS Microbiology Letters. 197:1-9. 2001
- cDNA Array Analysis of Altered Gene Expression in Human Endothelial Cells in Response toChlamydia pneumoniaeInfection. Infection and Immunity. 69:1420-1427. 2001
- Nucleic Acid Sequence Based Amplification (NASBA) of Chlamydia pneumoniae Major Outer Membrane Protein (ompA) mRNA with Bioluminescent Detection. Combinatorial Chemistry and High Throughput Screening. 3:315-327. 2000
- Quantitation of Chlamydia trachomatis 16S rRNA Using NASBA Amplification and a Bioluminescent Microtiter Plate Assay. Combinatorial Chemistry and High Throughput Screening. 3:303-313. 2000
- Analytical Sensitivity, Reproducibility of Results, and Clinical Performance of Five PCR Assays for Detecting Chlamydia pneumoniae DNA in Peripheral Blood Mononuclear Cells. Journal of Clinical Microbiology. 38:2622-2627. 2000
- Chlamydia pneumoniae Infection of Human Endothelial Cells Induces Proliferation of Smooth Muscle Cells via an Endothelial Cell-Derived Soluble Factor(s). Infection and Immunity. 67:2909-2915. 1999
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preprints
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theses