Journal of Clinical Investigation
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Overview
publication venue for
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Spliceosome malfunction causes neurodevelopmental disorders with overlapping features.
134:e171235.
2024
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HDACi promotes inflammatory remodeling of the tumor microenvironment to enhance epitope spreading and antitumor immunity.
132:e159283.
2022
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Aerobic exercise elicits clinical adaptations in myotonic dystrophy type 1 patients independently of pathophysiological changes.
132:e156125.
2022
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Functional characterization of CD4+ T cell receptors crossreactive for SARS-CoV-2 and endemic coronaviruses.
131:146922.
2021
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Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
131:1-22.
2021
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Normal and defective pathways in biogenesis and maintenance of the insulin storage pool.
131:142240.
2021
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The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury.
131:128650.
2021
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Panic prescribing has become omnipresent during the COVID-19 pandemic.
130:2752-2753.
2020
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Endogenous T cells prevent tumor immune escape following adoptive T cell therapy.
129:5400-5410.
2019
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Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.
129:3171-3184.
2019
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Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy.
129:1240-1256.
2019
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Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity.
129:518-530.
2018
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Tie2 protects the vasculature against thrombus formation in systemic inflammation.
128:1471-1484.
2018
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MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis.
125:4334-4348.
2015
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IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.
125:3766-3781.
2015
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Plasma fibronectin supports hemostasis and regulates thrombosis.
124:4281-4293.
2014
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Compromised genomic integrity impedes muscle growth after Atrx inactivation.
122:4412-4423.
2012
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HERV-K–specific T cells eliminate diverse HIV-1/2 and SIV primary isolates.
122:4473-4489.
2012
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Blood flow reprograms lymphatic vessels to blood vessels.
122:2006-2017.
2012
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Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity.
121:4903-4915.
2011
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The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies.
121:4537-4547.
2011
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Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8–mediated activation of TGF-β.
121:2863-2875.
2011
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Shank-interacting protein–like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells.
120:2094-2108.
2010
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Endothelial NOS, estrogen receptor β, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer.
119:1093-1108.
2009
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VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats.
119:1298-1311.
2009
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Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression.
118:2209-2218.
2008
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Complex two-gene modulation of lung disease severity in children with cystic fibrosis.
118:1040-1049.
2008
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Complex two-gene modulation of lung disease severity in children with cystic fibrosis.
118:1040-1049.
2008
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Adoptive immunotherapy of prostate cancer bone lesions using redirected effector lymphocytes.
114:1774-1781.
2004
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Adoptive immunotherapy of prostate cancer bone lesions using redirected effector lymphocytes.
114:1774-1781.
2004
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Tregs and allergic disease.
114:1389-1397.
2004
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Tregs and allergic disease.
114:1389-1397.
2004
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TNF-α is a critical negative regulator of type 1 immune activation during intracellular bacterial infection.
113:401-413.
2004
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TNF-α is a critical negative regulator of type 1 immune activation during intracellular bacterial infection.
113:401-413.
2004
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The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis.
112:58-66.
2003
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The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis.
112:58-66.
2003
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Heparan sulfate: Antithrombotic or not?.
111:952-954.
2003
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Heparan sulfate: Antithrombotic or not?.
111:952-954.
2003
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Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo.
111:479-486.
2003
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Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo.
111:479-486.
2003
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Generation of experimental allergic airways inflammation in the absence of draining lymph nodes.
108:577-583.
2001
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Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis.
107:1529-1536.
2001
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Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways.
107:1263-1273.
2001
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Enhanced intestinal transepithelial antigen transport in allergic rats is mediated by IgE and CD23 (FcεRII).
106:879-886.
2000
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IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion.
105:1697-1710.
2000
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Macrophages are a significant source of type 1 cytokines during mycobacterial infection.
103:1023-1029.
1999
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GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice..
102:1704-1714.
1998
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Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia..
102:1132-1141.
1998
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Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds..
101:2497-2505.
1998
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Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice..
101:1342-1353.
1998
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IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses..
101:311-320.
1998
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Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease..
100:2766-2776.
1997
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Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation..
100:2466-2475.
1997
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Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung..
100:768-776.
1997
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CD40 expression by human peripheral blood eosinophils..
97:1761-1766.
1996
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Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells..
97:1122-1128.
1996
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Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions..
97:1102-1110.
1996
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Patient selection may affect gene therapy success. Dominant negative effects observed for ornithine transcarbamylase in mouse and human hepatocytes..
97:826-832.
1996
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A single strand conformation polymorphism study of CD40 ligand. Efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome..
97:196-201.
1996
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Hyper IgM syndrome associated with defective CD40-mediated B cell activation..
94:1404-1409.
1994
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Behavioral consequences of bone marrow transplantation in the treatment of murine mucopolysaccharidosis type VII..
94:1180-1186.
1994
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Systemic administration of ciliary neurotrophic factor induces cachexia in rodents..
93:2632-2638.
1994
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Anchorage-independent colony growth of pulmonary fibroblasts derived from fibrotic human lung tissue..
93:1525-1532.
1994
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Depletion of OX-8 lymphocytes from the blood and airways using monoclonal antibodies enhances the late airway response in rats..
92:1477-1482.
1993
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Efficient adenoviral-mediated ornithine transcarbamylase expression in deficient mouse and human hepatocytes..
92:1580-1586.
1993
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Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs..
92:315-323.
1993
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Multimerin is found in the alpha-granules of resting platelets and is synthesized by a megakaryocytic cell line..
91:2630-2639.
1993
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Alpha 2-antiplasmin supplementation inhibits tissue plasminogen activator-induced fibrinogenolysis and bleeding with little effect on thrombolysis..
91:1343-1350.
1993
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An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis..
91:1138-1148.
1993
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Eosinophils in chronically inflamed human upper airway tissues express transforming growth factor beta 1 gene (TGF beta 1)..
89:1662-1668.
1992
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Plasma levels of elastase-specific fibrinopeptides correlate with proteinase inhibitor phenotype. Evidence for increased elastase activity in subjects with homozygous and heterozygous deficiency of alpha 1-proteinase inhibitor..
89:766-773.
1992
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An anticoagulant dermatan sulfate proteoglycan circulates in the pregnant woman and her fetus..
89:321-326.
1992
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Soluble fibrin degradation products potentiate tissue plasminogen activator-induced fibrinogen proteolysis..
87:1082-1090.
1991
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Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors..
86:385-391.
1990
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Urokinase has direct catalytic activity against fibrinogen and renders it less clottable by thrombin..
86:203-212.
1990
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Pathophysiology of rhinitis. Lactoferrin and lysozyme in nasal secretions..
84:1528-1535.
1989
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Human tissue-type plasminogen activator releases fibrinopeptides A and B from fibrinogen..
82:1700-1707.
1988
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Hemophilia B (Christmas disease) variants and carrier detection analyzed by DNA probes..
79:1204-1209.
1987
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Development of an assay for in vivo human neutrophil elastase activity. Increased elastase activity in patients with alpha 1-proteinase inhibitor deficiency..
78:155-162.
1986
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Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells..
77:645-648.
1986
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Immune-mediated thrombocytopenia of malaria..
71:832-836.
1983
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Reversal of shortened platelet survival in rats by the antifibrinolytic agent, epsilon aminocaproic acid..
71:159-164.
1983
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A molecular defect in two families with hemolytic poikilocytic anemia: reduction of high affinity membrane binding sites for ankyrin..
68:1566-1576.
1981
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Hemostatic Function, Survival, and Membrane Glycoprotein Changes in Young versus Old Rabbit Platelets.
68:1289-1294.
1981
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Basophil Production.
65:390-399.
1980
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Shortening of the Bleeding Time in Rabbits by Hydrocortisone Caused by Inhibition of Prostacyclin Generation by the Vessel Wall.
63:1026-1035.
1979
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Thrombogenic Effect of High-Dose Aspirin in Rabbits.
62:892-895.
1978
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The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization..
60:1191-1201.
1977
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Resolution of Experimental Pulmonary Emboli with Heparin and Streptokinase in Different Dosage Regimens.
54:782-791.
1974
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Altered sulfhydryl reactivity of hemoglobins and red blood cell membranes in congenital heinz body hemolytic anemia.
47:2664-2677.
1968
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The effect of platelet age on platelet adherence to collagen.
47:466-473.
1968
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Steady state measurement of regional ventilation to perfusion ratios in normal man..
45:1349-1356.
1966
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