Journal article
The landscape of RNA polymerase II associated chromatin interactions in prostate cancer
Abstract
Transcriptional dysregulation is a hallmark of prostate cancer (PCa). We mapped the RNA polymerase II-associated (RNA Pol II-associated) chromatin interactions in normal prostate cells and PCa cells. We discovered thousands of enhancer-promoter, enhancer-enhancer, as well as promoter-promoter chromatin interactions. These transcriptional hubs operate within the framework set by structural proteins - CTCF and cohesins - and are regulated by the …
Authors
Ramanand SG; Chen Y; Yuan J; Daescu K; Lambros M; Houlahan KE; Carreira S; Yuan W; Baek G; Sharp A
Journal
Journal of Clinical Investigation, Vol. 130, No. 8, pp. 3987–4005
Publisher
American Society for Clinical Investigation
Publication Date
June 22, 2020
DOI
10.1172/jci134260
ISSN
0021-9738