Journal article
The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization.
Abstract
This study was designed to investigate the mechanisms involved in fibromusculoelastic lesion formation produced by selective de-endothelialization by the intra-arterial balloon catheter technique in thrombocytopenic rabbits. Thrombocytopenia was induced and maintained for up to 30 days by daily injections fo highly specific sheep anti-rabbit platelet sera (APS). Evidence for re-endothelialization was obtained by i.v. Evans blue dye 30 min …
Authors
Friedman RJ; Stemerman MB; Wenz B; Moore S; Gauldie J; Gent M; Tiell ML; Spaet H
Journal
Journal of Clinical Investigation, Vol. 60, No. 5, pp. 1191–1201
Publisher
American Society for Clinical Investigation
Publication Date
November 1, 1977
DOI
10.1172/jci108872
ISSN
0021-9738