Journal article
Eosinophils in chronically inflamed human upper airway tissues express transforming growth factor beta 1 gene (TGF beta 1).
Abstract
Transforming growth factor beta (TGF beta) is a multifunctional protein which has been suggested to play a central role in the pathogenesis of chronic inflammation and fibrosis. Nasal polyposis is a condition affecting the upper airways characterized by the presence of chronic inflammation and varying degrees of fibrosis. To examine the potential role of TGF beta in the pathogenesis of this condition, we investigated gene expression and …
Authors
Ohno I; Lea RG; Flanders KC; Clark DA; Banwatt D; Dolovich J; Denburg J; Harley CB; Gauldie J; Jordana M
Journal
Journal of Clinical Investigation, Vol. 89, No. 5, pp. 1662–1668
Publisher
American Society for Clinical Investigation
Publication Date
May 1, 1992
DOI
10.1172/jci115764
ISSN
0021-9738