Journal article
Modulation of DEG/ENaCs by Amphiphiles Suggests Sensitivity to Membrane Alterations
Abstract
The bile acid-sensitive ion channel is activated by amphiphilic substances such as bile acids or artificial detergents via membrane alterations; however, the mechanism of membrane sensitivity of the bile acid-sensitive ion channel is not known. It has also not been systematically investigated whether other members of the degenerin/epithelial Na+ channel (DEG/ENaC) gene family are affected by amphiphilic compounds. Here, we show that DEG/ENaCs …
Authors
Schmidt A; Alsop RJ; Rimal R; Lenzig P; Joussen S; Gervasi NN; Khondker A; Gründer S; Rheinstädter MC; Wiemuth D
Journal
Biophysical Journal, Vol. 114, No. 6, pp. 1321–1335
Publisher
Elsevier
Publication Date
March 2018
DOI
10.1016/j.bpj.2018.01.028
ISSN
0006-3495