Journal article
Direct osteolysis induced by metastatic murine melanoma cells: Role of matrix metalloproteinases
Abstract
We examined the osteolytic ability of metastatic cells and the role of tumour matrix metalloproteinases (MMPs) in bone degradation. The histomorphometry of experimental bone metastases of B16/F1 melanoma cells showed that osteolysis was associated with a 90% decrease in osteoclast number and predominance of cancer cells overlaying resorption pits. In vitro, B16/F1 cells and their conditioned medium (CM) degraded 3H-proline-labelled …
Authors
Sanchez-Sweatman OH; Lee J; Orr FW; Singh G
Journal
European Journal of Cancer, Vol. 33, No. 6, pp. 918–925
Publisher
Elsevier
Publication Date
5 1997
DOI
10.1016/s0959-8049(97)00513-3
ISSN
0959-8049