Journal article
BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis
Abstract
OBJECTIVE: BRCA1, a tumor suppressor gene implicated in breast and ovarian cancers, exerts multiple effects on DNA repair and affords resistance against cellular stress responses. We hypothesized that BRCA1 limits endothelial cell apoptosis and dysfunction, and via this mechanism attenuates atherosclerosis.
METHODS: Loss and gain of function were achieved in cultured endothelial cells by silencing and overexpressing BRCA1, respectively. In vivo …
Authors
Singh KK; Shukla PC; Quan A; Al-Omran M; Lovren F; Pan Y; Brezden-Masley C; Ingram AJ; Stanford WL; Teoh H
Journal
Journal of Thoracic and Cardiovascular Surgery, Vol. 146, No. 4, pp. 949–960.e4
Publisher
Elsevier
Publication Date
October 2013
DOI
10.1016/j.jtcvs.2012.12.064
ISSN
0022-5223
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAnimalsApolipoproteins EApoptosisAtherosclerosisBRCA1 ProteinCarotid Artery DiseasesCells, CulturedDisease Models, AnimalEndothelial CellsGenetic TherapyGenetic VectorsHindlimbHuman Umbilical Vein Endothelial CellsHumansIschemiaMaleMiceMice, Inbred BALB CMice, KnockoutMuscle, SkeletalNeovascularization, PhysiologicNitric Oxide Synthase Type IIIPhosphorylationProto-Oncogene Proteins c-aktRNA InterferenceReactive Oxygen SpeciesRecovery of FunctionRegional Blood FlowTime FactorsTransfectionVascular Endothelial Growth Factor A