Journal article
Interferon-λ Mediates Oral Tolerance and Inhibits Antigen-Specific, T-Helper 2 Cell–Mediated Inflammation in Mouse Intestine
Abstract
BACKGROUND & AIMS: Oral tolerance is an important component of gastrointestinal homeostasis, but mechanisms of its development are not fully understood. Loss of oral tolerance occurs during food allergen-related inflammation in the gastrointestinal tract. Interferon (IFN)-λ regulates immunity, but its role in oral tolerance is not clear. We investigated the role and the mechanism of IFN-λ in the development of oral tolerance and its effect on …
Authors
He S; Chen X; Song C; Liu Z; Zhou L; Ma W; Zhao L; Li T; Tang S; Xing Z
Journal
Gastroenterology, Vol. 141, No. 1, pp. 249–258.e2
Publisher
Elsevier
Publication Date
7 2011
DOI
10.1053/j.gastro.2011.04.006
ISSN
0016-5085
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsApoptosisBlotting, WesternCD3 ComplexCells, CulturedCytokinesDendritic CellsDisease Models, AnimalEnteritisFlow CytometryGenes, T-Cell ReceptorImmune ToleranceImmunity, MucosalImmunohistochemistryIntestinesMiceMice, Inbred BALB CMice, TransgenicMouth MucosaOvalbuminPhagocytosisReceptors, CytokineTh2 Cells