Association of Minimal Clinically Important Difference With Infarct Volume in Clinical Poststroke Outcomes.

BACKGROUND: Infarct volume is an imaging biomarker of ischemic tissue injury strongly correlated with poststroke outcomes and reperfusion benefit. We aimed to evaluate the follow-up infarct volume (FIV) difference corresponding to a 1%, 5%, and 10% increase in probability of excellent functional outcomes after intravenous thrombolysis. METHODS: Data are from the AcT trial (Alteplase Compared to Tenecteplase in Patients With Acute Ischemic …