Journal article
Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax.
Abstract
After exposure to stressful stimuli, apoptotic signals can be relayed to mitochondria by pro-apoptotic activator proteins, tBid (truncated Bid/p15) and Bim (Bcl-2 interacting mediator), which activate Bax (Bcl-2 associated X protein) and or Bak (Bcl-2 antagonist/killer) to induce mitochondrial outer membrane (MOM) permeabilization (MOMP). These protein-protein and protein-membrane interactions are critical for apoptosis regulation, since MOMP …
Authors
Shamas-Din A; Bindner S; Chi X; Leber B; Andrews DW; Fradin C
Journal
Biochemical Journal, Vol. 467, No. 3, pp. 495–505
Publisher
Portland Press
Publication Date
May 1, 2015
DOI
10.1042/bj20141291
ISSN
0264-6021
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsApoptosisApoptosis Regulatory ProteinsBH3 Interacting Domain Death Agonist ProteinBcl-2-Like Protein 11CardiolipinsCholesterolHumansLiposomesMembrane LipidsMembrane ProteinsMiceMice, KnockoutMitochondria, LiverMitochondrial MembranesModels, BiologicalMutagenesis, Site-DirectedPermeabilityProtein ConformationProto-Oncogene ProteinsRecombinant Proteinsbcl-2 Homologous Antagonist-Killer Proteinbcl-2-Associated X Protein