Adjusting for Baseline Covariates in Net Benefit Regression: How You Adjust Matters

Background and ObjectiveThe literature has shown that different baseline adjustment approaches lead to different results when examining cost and quality-adjusted life-years. To our knowledge, the concept of baseline adjustment in a net benefit (NB) regression has not been studied. The purpose of the study was to explore the impact of different baseline adjustment approaches in an NB framework on the cost effectiveness of an intervention using …