Journal article
Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas
Abstract
Amplification of genes in the 12q13-15 region occurs frequently in several malignancies including osteosarcoma. The products of these amplified genes are thought to provide cancer cells with a selective growth advantage; however, the specific gene(s) driving this amplicon is unknown. We have previously shown that the SAS gene is amplified in most parosteal osteosarcomas. In this study we analysed additional putative growth regulatory genes in …
Authors
Wunder JS; Eppert K; Burrow SR; Gogkoz N; Bell RS; Andrulis IL
Journal
Oncogene, Vol. 18, No. 3, pp. 783–788
Publisher
Springer Nature
Publication Date
January 21, 1999
DOI
10.1038/sj.onc.1202346
ISSN
0950-9232