Journal article
Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis
Abstract
BACKGROUND: Aortic stenosis (AS) is an active process with similarities to atherosclerosis. The objective of this study was to assess the effect of cholesterol lowering with rosuvastatin on the progression of AS.
METHODS AND RESULTS: This was a randomized, double-blind, placebo-controlled trial in asymptomatic patients with mild to moderate AS and no clinical indications for cholesterol lowering. The patients were randomized to receive either …
Authors
Chan KL; Teo K; Dumesnil JG; Ni A; Tam J
Journal
Circulation, Vol. 121, No. 2, pp. 306–314
Publisher
Wolters Kluwer
Publication Date
January 19, 2010
DOI
10.1161/circulationaha.109.900027
ISSN
0009-7322
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAgedAged, 80 and overAortic Valve StenosisCholesterolDisease ProgressionDouble-Blind MethodElectrocardiographyFemaleFluorobenzenesFollow-Up StudiesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLipid MetabolismLipidsMaleMiddle AgedPyrimidinesRosuvastatin CalciumSulfonamidesTreatment FailureYoung Adult