Temporal trends and patterns of early clopidogrel use across the spectrum of acute coronary syndromes

BACKGROUND: Randomized trials have established efficacy of clopidogrel in various types of acute coronary syndromes (ACS). The objective of this study was to examine the temporal trends and patterns of early clopidogrel use (within the first 24 hours of hospitalization) across the spectrum of patients with ACS in Canada. METHODS: Using the multinational, prospective GRACE (Global Registry of Acute Coronary Events) and GRACE(2), we identified …