Journal article
Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes
Abstract
Aims/hypothesisEpidemiological studies report an increased risk of obesity and type 2 diabetes in children born to women who smoked during pregnancy. This study examines the effect of fetal and neonatal exposure to nicotine, the major addictive component of cigarettes, on postnatal growth, adiposity and glucose homeostasis.MethodsFemale Wistar rats were given either saline (vehicle) or nicotine (1 mg kg−1 day−1) during pregnancy and lactation. …
Authors
Holloway AC; Lim GE; Petrik JJ; Foster WG; Morrison KM; Gerstein HC
Journal
Diabetologia, Vol. 48, No. 12, pp. 2661–2666
Publisher
Springer Nature
Publication Date
December 2005
DOI
10.1007/s00125-005-0022-5
ISSN
0012-186X