Journal article
Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function.
Abstract
Long-term peritoneal dialysis is limited by physiologic changes in the peritoneum that lead to ultrafiltration failure. To determine the role of profibrotic cytokines in the alteration of peritoneal transport, a rodent model of transforming growth factor-beta (TGF-beta)-mediated peritoneal fibrosis was established. An adenoviral vector driving the active form of TGF-beta1 (AdTGFbeta1) was administered intraperitoneally, and peritoneal structure …
Authors
Margetts PJ; Kolb M; Galt T; Hoff CM; Shockley TR; Gauldie J
Journal
Journal of the American Society of Nephrology, Vol. 12, No. 10, pp. 2029–2039
Publisher
Wolters Kluwer
Publication Date
10 2001
DOI
10.1681/asn.v12102029
ISSN
1046-6673