Journal article
Ly6Chi Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis
Abstract
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a devastating disease. Antiinflammatory therapies, including corticosteroids, are of no benefit. The role of monocytes and macrophages is therefore controversial.
OBJECTIVES: To define the role of monocytes and macrophages during lung fibrogenesis and resolution, and explore the phenotype of the cells involved.
Authors
Gibbons MA; MacKinnon AC; Ramachandran P; Dhaliwal K; Duffin R; Phythian-Adams AT; van Rooijen N; Haslett C; Howie SE; Simpson AJ
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 184, No. 5, pp. 569–581
Publisher
American Thoracic Society
Publication Date
September 1, 2011
DOI
10.1164/rccm.201010-1719oc
ISSN
1073-449X