Journal article
Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation
Abstract
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by myofibroblast proliferation. Transition of epithelial/mesothelial cells into myofibroblasts [epithelial-to-mesenchymal transition (EMT)] occurs under the influence of transforming growth factor (TGF)-β1, with Snail being a major transcription factor. We study here the role of the heat-shock protein HSP27 in fibrogenesis and EMT. In vitro, we have up- and …
Authors
Wettstein G; Bellaye P; Kolb M; Hammann A; Crestani B; Soler P; Marchal‐Somme J; Hazoume A; Gauldie J; Gunther A
Journal
The FASEB Journal, Vol. 27, No. 4, pp. 1549–1560
Publisher
Wiley
Publication Date
April 2013
DOI
10.1096/fj.12-220053
ISSN
0892-6638