An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein Journal Articles uri icon

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  • The human endogenous retrovirus K (HERV-K) family of endogenous retroviruses consists of ≈50 proviral copies per haploid human genome. Herein, the HERV-Ks are shown to encode a sequence-specific nuclear RNA export factor, termed K-Rev, that is functionally analogous to the HIV-1 Rev protein. Like HIV-1 Rev, K-Rev binds to both the Crm1 nuclear export factor and to a cis-acting viral RNA target to activate nuclear export of unspliced RNAs. Surprisingly, this HERV-K RNA sequence, which is encoded within the HERV-K long terminal repeat, is also recognized by HIV-1 Rev. These data provide surprising evidence for an evolutionary link between HIV-1 and a group of endogenous retroviruses that first entered the human genome ≈30 million years ago.


  • Yang, Jin
  • Bogerd, Hal P
  • Peng, Sheila
  • Wiegand, Heather
  • Truant, Ray
  • Cullen, Bryan R

publication date

  • November 9, 1999