Journal article
Canadian Association of Neurosciences Review: Polyglutamine Expansion Neurodegenerative Diseases
Abstract
Since the early 1990s, DNA triplet repeat expansions have been found to be the cause in an ever increasing number of genetic neurologic diseases. A subset of this large family of genetic diseases has the expansion of a CAG DNA triplet in the open reading frame of a coding exon. The result of this DNA expansion is the expression of expanded glutamine amino acid repeat tracts in the affected proteins, leading to the term, Polyglutamine Diseases, …
Authors
Truant R; Raymond LA; Xia J; Pinchev D; Burtnik A; Atwal RS
Journal
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Vol. 33, No. 3, pp. 278–291
Publisher
Cambridge University Press (CUP)
Publication Date
August 2006
DOI
10.1017/s031716710000514x
ISSN
0317-1671