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- A huntingtin-mediated fast stress response halting endosomal trafficking is defective in Huntington's disease Academic Article
- A patient-derived cellular model for Huntington’s disease reveals phenotypes at clinically relevant CAG lengths Academic Article
- A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy Academic Article
- Canadian Association of Neurosciences Review: Polyglutamine Expansion Neurodegenerative Diseases Academic Article
- DNA Repair Signaling of Huntingtin: The Next Link Between Late-Onset Neurodegenerative Disease and Oxidative DNA Damage Academic Article
- Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice Academic Article
- High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry Academic Article
- Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization Academic Article
- Huntingtin contains a highly conserved nuclear export signal Academic Article
- Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity Academic Article
- Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex Academic Article
- Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function Academic Article
- Hypothesis: huntingtin may function in membrane association and vesicular traffickingThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease. Conference Paper
- Identification of a Karyopherin β1/β2 Proline-Tyrosine Nuclear Localization Signal in Huntingtin Protein Academic Article
- Inhibition of Metabotropic Glutamate Receptor Signaling by the Huntingtin-binding Protein Optineurin Academic Article
- Kinase inhibitors modulate huntingtin cell localization and toxicity Academic Article
- Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions Academic Article
- Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease Academic Article
- Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington's disease Academic Article
- Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin Academic Article
- Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington’s disease pathology Academic Article
- The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal Academic Article