selected scholarly activity
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conferences
- MicroRNA-145 Targeted Therapy Reduces Atherosclerosis. Circulation. S81-S90. 2012
- Determining how 4‐phenylbutyrate inhibits tunicamycininduced acute kidney injury. The FASEB Journal. 2012
- BRCA1 IMPROVES ENDOTHELIAL FUNCTION AND LIMITS ATHEROSCLEROSIS. Canadian Journal of Cardiology. 120D-120D. 2010
- BRCA1 is a Novel Regulator of Endothelial Function and Limits Atherosclerosis. Circulation. S928-S928. 2009
- Cardiac disease, vascular disease and medication use in patients with chronic renal insufficiency referred to nephrologists.. Journal of the American Society of Nephrology. 792A-792A. 2003
- Metabolic complications in patients with chronic renal insufficiency referred to nephrologists.. Journal of the American Society of Nephrology. 791A-791A. 2003
- Stretch-induced Raf-1 activation in mesangial cells requires focal adhesion-cytoskeletal integrity.. Journal of the American Society of Nephrology. 336A-336A. 2003
- Stretch-induced MAPK activation in mesangial cells requires Rho-mediated cytoskeletal reorganization.. Journal of the American Society of Nephrology. 87A-87A. 2002
- Protooncogene expression and diabetic kidney injury.. Kidney International, Supplement. S70-S76. 1997
- Renin-angiotensin system (RAS) genetic polymorphisms and left ventricular hypertrophy (LVH).. Journal of the American Society of Nephrology. A0658-A0658. 1997
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journal articles
- Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice. Endocrinology. 159:1479-1495. 2018
- Which Patients With Atrial Fibrillation and Chronic Kidney Disease Should Receive Anticoagulation—And With Which Anticoagulant?. Canadian Journal of Cardiology. 33:211-213. 2017
- Coronary Artery Calcification, Cardiovascular Events, and Death: A Prospective Cohort Study of Incident Patients on Hemodialysis. Canadian Journal of Kidney Health and Disease. 2:65-65. 2015
- 4-Phenylbutyrate Inhibits Tunicamycin-Induced Acute Kidney Injury via CHOP/GADD153 Repression. PLoS ONE. 9:e84663-e84663. 2014
- Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease. American Journal of Physiology - Renal Physiology. 305:F1466-F1476. 2013
- BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis. Journal of Thoracic and Cardiovascular Surgery. 146:949-960.e4. 2013
- Caveolin-1 deficiency protects against mesangial matrix expansion in a mouse model of type 1 diabetic nephropathy. Diabetologia. 56:2068-2077. 2013
- TGFβ receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cells. Journal of Cell Science. 126:3697-3712. 2013
- Stroke Prevention in Atrial Fibrillation Patients With Chronic Kidney Disease. Canadian Journal of Cardiology. 29:S71-S78. 2013
- Propagation of Human Prostate Cancer Stem-Like Cells Occurs through EGFR-Mediated ERK Activation. PLoS ONE. 8:e61716-e61716. 2013
- Anticoagulants in Patients with Atrial Fibrillation and End-Stage Renal Disease. Postgraduate Medicine. 124:17-25. 2012
- Anticoagulants in atrial fibrillation patients with chronic kidney disease. Nature Reviews Nephrology. 8:569-578. 2012
- ER stress contributes to renal proximal tubule injury by increasing SREBP-2-mediated lipid accumulation and apoptotic cell death. American Journal of Physiology - Renal Physiology. 303:F266-F278. 2012
- SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells. American Journal of Physiology - Renal Physiology. 302:F329-F341. 2012
- High glucose-induced RhoA activation requires caveolae and PKCβ1-mediated ROS generation. American Journal of Physiology - Renal Physiology. 302:F159-F172. 2012
- Low-Intensity Adjusted-Dose Warfarin for the Prevention of Hemodialysis Catheter Failure. American Society of Nephrology. Clinical Journal. 6:1018-1024. 2011
- HB-EGF release mediates glucose-induced activation of the epidermal growth factor receptor in mesangial cells. American Journal of Physiology - Renal Physiology. 300:F921-F931. 2011
- Induction of the unfolded protein response after monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions. The FASEB Journal. 25:576-589. 2011
- α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells. Nature Communications. 2:307. 2011
- Mechanical Strain-Induced RhoA Activation Requires NADPH Oxidase-Mediated ROS Generation in Caveolae. Antioxidants and Redox Signaling. 13:959-973. 2010
- Mechanical stretch-induced RhoA activation is mediated by the RhoGEF Vav2 in mesangial cells. Cellular Signalling. 22:34-40. 2010
- EGFR-PLCγ1 signaling mediates high glucose-induced PKCβ1-Akt activation and collagen I upregulation in mesangial cells. American Journal of Physiology - Renal Physiology. 297:F822-F834. 2009
- PKC-β1 Mediates Glucose-Induced Akt Activation and TGF-β1 Upregulation in Mesangial Cells. Journal of the American Society of Nephrology. 20:554-566. 2009
- TGFβ-induced RhoA activation and fibronectin production in mesangial cells require caveolae. American Journal of Physiology - Renal Physiology. 295:F153-F164. 2008
- RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease. Diabetes. 57:1683-1692. 2008
- Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells. Diabetologia. 50:2008-2018. 2007
- Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells. Cellular Signalling. 19:1690-1700. 2007
- Homocysteine induces mesangial cell apoptosis via activation of p38-mitogen-activated protein kinase. Kidney International. 71:304-311. 2007
- RhoA Activation in Mesangial Cells by Mechanical Strain Depends on Caveolae and Caveolin-1 Interaction. Journal of the American Society of Nephrology. 18:189-198. 2007
- Akt Mediates Mechanical Strain-Induced Collagen Production by Mesangial Cells. Journal of the American Society of Nephrology. 16:1661-1672. 2005
- Stretch-induced Raf-1 activation in mesangial cells requires actin cytoskeletal integrity. Cellular Signalling. 17:311-320. 2005
- Activation of mesangial cell MAPK in responseto homocysteine. Kidney International. 66:733-745. 2004
- Nitric Oxide Inhibits Stretch-Induced MAPK Activation in Mesangial Cells Through RhoA Inactivation. Journal of the American Society of Nephrology. 14:2790-2800. 2003
- Low-Intensity Warfarin Is Ineffective for the Prevention of PTFE Graft Failure in Patients on Hemodialysis. Journal of the American Society of Nephrology. 13:2331-2337. 2002
- Utility of ultrasonographic venous assessment prior to forearm arteriovenous fistula creation. Clinical Nephrology. 58:122-127. 2002
- 17β-Estradiol Modulates Mechanical Strain-induced MAPK Activation in Mesangial Cells. Journal of Biological Chemistry. 277:9387-9394. 2002
- The Clinical Utility of Doppler Ultrasound Prior to Arteriovenous Fistula Creation. Seminars in Dialysis. 14:314-317. 2001
- Akt Is Activated in Response to an Apoptotic Signal. Journal of Biological Chemistry. 276:30461-30466. 2001
- Thrombolysis for restoration of patency to haemodialysis central venous catheters: a systematic review.. Journal of Thrombosis and Thrombolysis. 11:127-136. 2001
- Metabolic investigation of recurrent nephrolithiasis: compliance with recommendations. Urology. 56:915-920. 2000
- NO Inhibits Stretch-induced MAPK Activity by Cytoskeletal Disruption. Journal of Biological Chemistry. 275:40301-40306. 2000
- Stretch activation of Jun N-terminal kinase/stress-activated protein kinase in mesangial cells. Kidney International. 58:1431-1439. 2000
- Nitric oxide modulates stretch activation of mitogen-activated protein kinases in mesangial cells. Kidney International. 58:1067-1077. 2000
- Nitric oxide modulates mechanical strain-induced activation of p38 MAPK in mesangial cells. American Journal of Physiology - Renal Physiology. 279:F243-F251. 2000
- Prolonged sulfonylurea-induced hypoglycemia in diabetic patients with end-stage renal disease. American Journal of Kidney Diseases. 35:500-505. 2000
- Stress-responsive signal transduction mechanisms in glomerular cells. Current Opinion in Nephrology and Hypertension. 9:49-55. 2000
- Mesangial cell signaling cascades in response to mechanical strain and glucose. Kidney International. 56:1721-1728. 1999
- Activation of mesangial cell signaling cascades in response to mechanical strain. Kidney International. 55:476-485. 1999
- Effects of two low-flux cellulose acetate dialysers on plasma lipids and lipoproteins-a cross-over trial. Nephrology Dialysis Transplantation. 13:1452-1457. 1998
- Dietary alteration of dihomogamma-linolenic acid arachidonic acid ratio in a rat 5/6-renal-ablation model. Journal of the American Society of Nephrology. 7:1024-1031. 1996
- Dietary alteration of dihomogamma-linolenic acid/arachidonic acid ratio in a rat 5/6-renal-ablation model. The Nutrition & Kidney Disease Research Group.. Journal of the American Society of Nephrology. 7:1024-1031. 1996
- Effects of flaxseed and flax oil diets in a rat-5/6 renal ablation model. American Journal of Kidney Diseases. 25:320-329. 1995