Journal article
Biodistribution of covalent antithrombin-heparin complexes
Abstract
We have developed a covalent antithrombin-heparin (ATH) complex with advantages compared to non-covalent antithrombin:heparin (AT:H) mixtures. In addition to increased activity, ATH has a longer intravenous half-life that is partly due to reduced plasma protein binding. Given ATH's altered clearance, we investigated biodistribution of ATH in vivo. ATH made from either human plasma-derived AT (pATH) or recombinant human (produced in goats) AT …
Authors
Chindemi PA; Klement P; Konecny F; Berry LR; Chan AKC
Journal
Thrombosis and Haemostasis, Vol. 95, No. 04, pp. 629–636
Publisher
Thieme
Publication Date
2006
DOI
10.1160/th05-11-0728
ISSN
0340-6245