Filip Konecny - McMaster Experts

Affiliations

Faculty of Health Sciences, McMaster University
Lecturer (Adjunct), Surgery, Faculty of Health Sciences
Senior post-doctoral research Fellow, Division of Fundamental Neurobiology,, Toronto Western Research Institute (TWRI))
Associate/ Research staff, Medical Biophysics, Schulich School of Medicine & Dentistry
Plastic Surgery Training Coordinator, Surgery, Div. Plastic Surgery, McMaster University
Senior Post-doctoral research Fellow, Department of Cardiology, Division of Cardiology, Toronto General Research Institute

Research Areas

Animal Physiology (RA)
Animal cell and molecular biology (RA)
Animal physiology, circulation (RA)
Basic medicine and life sciences (RA)
Basic pharmacology (RA)
Biomaterials (RA)
Biomaterials and Devices (RA)
Cardiology and circulatory sciences (including cardiovascular disease) (RA)
Cardiorespiratory medicine and hematology (RA)
Education (RA)
Health sciences (RA)
Hematology (RA)
Medical and biomedical engineering (RA)
Medical devices (RA)
Pharmacogenomics (RA)
Proteins and peptides (RA)
Veterinary medicine (RA)
Veterinary surgery (RA)

Scholarly Activity in McMaster Experts

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selected scholarly activity

conferences
- Comprehensive Characterization of RV Function in Pulmonary Arterial Hypertension Model With Mitochondrial Dysfunction. A14. THIS IS GETTING COMPLICATED: EPIGENETICS, -OMICS, AND CELL SIGNALING IN PULMONARY HYPERTENSION. a1017-a1017. 2023
- Intra-Aortic Pump Provides Acute Hemodynamic Benefit in Preclinical Model of STEMI. Journal of the American College of Cardiology. B86-B86. 2021
- Intra-Aortic Unloading Before Reperfusion Reduces Infarct Size in a Preclinical Model of STEMI. Journal of the American College of Cardiology. B65-B65. 2021
- Load-Independent Systolic Dysfunction and Altered Z-Disc Protein Phosphorylation in Swine with Stretch-Induced Myocardial Stunning. Circulation Research. 2019
- Chronic Cardiac Output measurements in unrestrained rats: Surgical description. The FASEB Journal. 2018
- Persistent Left Ventricular Diastolic Stiffening Despite Cessation of Intermittent Myocardial Stretch in Swine. The FASEB Journal. 2018
- Intermittent Myocardial Stretch Elicits a Reduction in Left Ventricular Diastolic Compliance and Pathologic Characteristics of Heart Failure With Preserved Ejection Fraction in Swine. Circulation. 2017
- Initial studies of cardiovascular monitoring feasibility using EndoGear 2, a fully implantable telemetry system in swine model. The FASEB Journal. 2017
- Real-time telemetric physiologic recordings of ventricle pressure-volume in an awake swine model with histopathological evaluation. 2015 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (BIOCAS). 1-4. 2015
- Real-Time Telemetric Physiologic Recordings of Ventricle Pressure-Volume in an Awake Swine Model with Histopathological Evaluation. 2015 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (BIOCAS). 466-469. 2015
- P27 Inhibits IkBa-Degradation, Attenuates Inflammation, Improves Cardiac Function and Increases Survival Following LPS. Circulation. 2012
- Ablation of Pink1 Evokes Spontaneous Early-Onset Cardiac Left Ventricular Hypertrophy and Hypersensitivity to Biomechanical Stress. Circulation. 2010
- Inactivation of DJ-1/Park7 Promotes Pathologic Cardiac Hypertrophy by Inhibiting Hif-1 alpha and Promoting Myocyte Apoptosis During Biomechanical Stress. Circulation. 2010
- Angiogenic Cytokine-conjugated Injectable Hydrogel Stabilized a Cardiac Infarct, Increased Blood Vessel Density and Improved Function. Circulation. S997-S997. 2009
- p27kip1 Attenuates Endotoxin-Induced Cardiac Dysfunction Through Inhibition of the IKK1-NF-kB Pathway. Circulation Research. E24-E24. 2009
journal articles
- Early elevations in arterial pressure: a contributor to rapid depressive symptom emergence in female Zucker rats with metabolic disease?. Journal of applied physiology. 137:1324-1340. 2024
- Left Ventricular Unloading Using Intra-aortic Entrainment Pumping Before Reperfusion Reduces Post-AMI Infarct Size.. Journal of Cardiac Failure. S1071-9164(24)00316-6. 2024
- Abstract Mo100: Predictive Accuracy of Rightward Extrapolation of the Left Ventricular End-Diastolic Pressure-Volume Relationship in Healthy Swine. Circulation Research. 135:amo100-amo100. 2024
- Editorial: Advanced invasive hemodynamics: pressure-volume maneuvers to obtain load-independent indices.. Frontiers in Cardiovascular Medicine. 11:1468811. 2024
- Predictive Accuracy of Traditional Methods to Assess Left Ventricular Stiffness in a Porcine Model of Heart Failure with Preserved Ejection Fraction. Physiology. 38. 2023
- A cross‐species validation of single‐beat metrics of cardiac contractility. Journal of Physiology. 600:4779-4806. 2022
- Preservation of Right Ventricular Contractility After Transient Phenylephrine‐Induced Pressure Overload in Swine. The FASEB Journal. 36. 2022
- Influence of right ventricular pressure and volume overload on right and left ventricular diastolic function. Journal of Thoracic and Cardiovascular Surgery. 163:e299-e308. 2022
- Abstract 622: Load-Independent Systolic Dysfunction and Altered Z-Disc Protein Phosphorylation in Swine with Stretch-Induced Myocardial Stunning. Circulation Research. 125. 2019
- Adaptive Reductions in Left Ventricular Diastolic Compliance Protect the Heart From Stretch-Induced Stunning. JACC: Basic to Translational Science. 4:527-541. 2019
- Dual Admittance Catheter‐Derived Biventricular Pressure‐Volume Analysis in Swine: Comparison with Contrast‐Enhanced Computed Tomography During Transient Pressure Overload. The FASEB Journal. 33. 2019
- Left atrial pressure measurement in a rat is currently impossible due to size limitations of balloon occlusion catheter. Journal of Thoracic and Cardiovascular Surgery. 156:1160-1161. 2018
- Improving Surgical Methods for Studying Vascular Grafts in Animal Models. Tissue Engineering - Part C: Methods. 24:457-464. 2018
- Chronic Cardiac Output measurements in unrestrained rats: Surgical description. The FASEB Journal. 32:901.9-901.9. 2018
- Persistent Left Ventricular Diastolic Stiffening Despite Cessation of Intermittent Myocardial Stretch in Swine. The FASEB Journal. 32:848.9-848.9. 2018
- Reply. JACC: Cardiovascular Interventions. 10:842-843. 2017
- Comparative Hemodynamic Effects of Contemporary Percutaneous Mechanical Circulatory Support Devices in a Porcine Model of Acute Myocardial Infarction. JACC: Cardiovascular Interventions. 9:2292-2303. 2016
- In–vivo characterization of left–ventricle pressure–volume telemetry system in swine model. Biomedical Microdevices. 18:75. 2016
- Assessment of Experimental Permanent Coronary Artery Ligation Using Echocardiography and Invasive Real-Time Pressure-Volume (PV): A Practical Tips to Evaluate Rat Hemodynamics. International Journal of Clinical and Experimental Medical Sciences. 2:40-40. 2016
- Influence of right ventricular remodeling on ventricular function, flow and energetics in pulmonary regurgitation vs. stenosis: a 4-dimensional phase contrast MRI and admittance catheterization study. Journal of Cardiovascular Magnetic Resonance. 18:O95-O95. 2016
- Hemodynamic Assessment Using Pressure-Volume (PV) During Mechanical Circulatory Support. International Journal of Clinical and Experimental Medical Sciences. 1:70-70. 2015
- Abstract 16393: Right Ventricular Energetics and Power in Pulmonary Regurgitation vs. Stenosis Using Four-Dimensional Phase-Contrast Magnetic Resonance. Circulation. 130. 2014
- Magnetic resonance imaging (MRI) assessment of ventricular remodeling after myocardial infarction in rabbits.. Comparative Medicine. 63:205. 2013
- Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo. Proceedings of the National Academy of Sciences of the United States of America. 110:6085-6090. 2013
- Anti-apoptotic function of the E2F transcription factor 4 (E2F4)/p130, a member of retinoblastoma gene family in cardiac myocytes. Journal of Molecular and Cellular Cardiology. 53:820-828. 2012
- Post-myocardial infarct p27 fusion protein intravenous delivery averts adverse remodelling and improves heart function and survival in rodents. Cardiovascular Research (CVR). 94:492-500. 2012
- Uterine cells are recruited to the infarcted heart and improve cardiac outcomes in female rats. Journal of Molecular and Cellular Cardiology. 52:1265-1273. 2012
- 394 Control of Cardiac Metabolism and Growth by DJ-1. The Journal of Heart and Lung Transplantation. 31:S140-S140. 2012
- 195 Uterine stem cells are recruited to the infarcted myocardium for cardiac regeneration. Canadian Journal of Cardiology. 27:S130-S131. 2011
- PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proceedings of the National Academy of Sciences of the United States of America. 108:9572-9577. 2011
- Infarct stabilization and cardiac repair with a VEGF-conjugated, injectable hydrogel. Biomaterials. 32:579-586. 2011
- Review of cellular and molecular pathways linking thrombosis and innate immune system during sepsis.. Journal of Research in Medical Sciences. 15:348-358. 2010
- Thromboembolic Conditions, Aetiology Diagnosis and Treatment in Dogs and Cats. Acta Veterinaria Brno. 79:497-508. 2010
- F003 La délétion de microsomal prostaglandin E2 synthase-1 (mPGES-1) dans les leucocytes de la moelle osseuse entraîne un remodelage ventriculaire gauche défavorable en post infarctus du myocarde. Archives of Cardiovascular Diseases. 102:S53-S54. 2009
- Inherited trombophilic states and pulmonary embolism.. Journal of Research in Medical Sciences. 14:43-56. 2009
- Abstract 4301: Chimeric Mice Lacking Microsomal Prostaglandin E ₂ Synthase-1 (mPGES) In Bone Marrow Develop Adverse Left Ventricular Remodelling After Myocardial Infarction. Circulation. 118. 2008
- A model of massive pulmonary embolism, development and characterization - The pre-clinical steps forward and details of the progress. Journal of Research in Medical Sciences. 13:121-134. 2008
- Evaluation of Two Recombinant Plasminogen Activators in Massive Pulmonary Embolism Model and Potato Carboxypeptidase Inhibitor (PCI) role in Inhibition of Thrombin Activatable Fibrinolysis Inhibitor TAFIa in Lungs. Recent Patents on Endocrine, Metabolic and Immune Drug Discovery. 2:45-56. 2008
- Pulmonary embolism and vascular injury: What is the role of thrombin?. Journal of Research in Medical Sciences. 12:203-216. 2007
- Massive pulmonary embolism: The predisposing and complicating factors, its current diagnostic approaches and critical importance of early diagnostic physical exam. Journal of Research in Medical Sciences. 11:406-414. 2006
- Biodistribution of covalent antithrombin-heparin complexes. Thrombosis and Haemostasis. 95:629-636. 2006
- Hemodynamic Characterization Of Pulmonary Artery Hypertension In A Rat. European Journal of Medical and Health Sciences. 2.
- Rodent General Anesthesia Suitable for Measurement of Experimental Invasive Hemodynamics. European Journal of Biology and Biotechnology. 2:33-43.
- Systolic Indices of Cardiac Contractility: Modeling and Analysis using Pressure-Volume Loop. European Journal of Medical and Health Sciences. 5:5-12.
- Targeting initiation and progression of Cushing disease by protecting levels of cell cycle inhibitor (p27) in veterinary medicine. Academia Letters.
- The Left Ventricular End-Systolic Pressure Correlation with Aortic Valve Timing; a Novel Inotropic Index Description Using a Dual Pressure Catheter.. Journal of Cardiology and Clinical Management. 1:1-16.
preprints
- Persistent Interstitial Fibrosis and Left Ventricular Stiffening Despite Cessation of Repetitive Pressure Overload in Swine