selected scholarly activity
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chapters
- Chapter 53 Construction and Propagation of Human Adenovirus Vectors. 435-443. 2006
- Construction and Propagation of Human Adenovirus Vectors. 435-443. 2006
- Construction and propagation of human adenovirus vectors. 435-443. 2005
- Adenoviral Vector Construction I. 71-104. 2002
- Construction of First-Generation Adenoviral Vectors. Methods in Molecular Medicine. 389-414. 2002
- Preparation of Helper-Dependent Adenoviral Vectors. Methods in Molecular Medicine. 371-388. 2002
- CHAPTER 16 Adenovirus-Based Expression Vectors and Recombinant Vaccines. Biotechnology (Reading, Mass.). 363-390. 1992
- Transformation by and Oncogenicity of Human Adenoviruses. 339-398. 1984
- Discussion Mammalian Cell Killing by Inhibitors of DNA Synthesis. Recent Results in Cancer Research. 109-117. 1969
- Adenoviral Vectors in Gene Therapy
- Adenovirus Vectors in Gene Therapy
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conferences
- Prophylactic and therapeutic application of an adenovirus vector expressing IL-12 against leishmaniasis in BALB/c mice. The FASEB Journal. A941-A941. 2005
- Point mutations in the lysosomal sialidase gene cause tissue-specific sialidase deficiency in SM/J mice. Molecular Biology of the Cell. 104A-104A. 2002
- Vbeta 8.2 TCR-centered regulation of experimental autoimmune encephalomyelitis is disrupted by co-administration with adenovirus vectors expressing either interleukin-4 or 10.. The FASEB Journal. A1058-A1058. 2002
- Helper-dependent adenovirus delivery of a canine FVIIIB-domain deleted transgene in murine and canine models of hemophilia A.. Blood. 695A-696A. 2001
- Large nontransplanted hepatocellular carcinoma in woodchucks: treatment with adenovirus-mediated delivery of interleukin-12/B7.1 genes. Cancer Gene Therapy. 921-922. 2001
- A phase I study of adenovirus engineered, interleukin 2 (IL-2) secreting, autologous plasma cell vaccination for the treatment of multiple myeloma.. Blood. 705A-705A. 1999
- A single administration of the IL-4 or IL-12 gene along with self-peptides has long-lasting but opposite effects on autoantibody production in lupus mice.. Arthritis and Rheumatism. S362-S362. 1999
- A single administration of vectors that express IL-4 or IL-12 genes, with self-peptides induce long-lasting, but opposite, effect on anti-DNA antibody production in lupus mice.. Arthritis and Rheumatism. S60-S60. 1999
- Adenoviral gene transfer of active TGF-beta to the colonic epithelium causes fibrosis and strictures. Gastroenterology. A685-A685. 1999
- Mast cell hyperplasia and heterogeneity in a TGF-beta 1-induced model of pulmonary fibrosis.. American Journal of Respiratory and Critical Care Medicine. A402-A402. 1999
- The facilitative role of epithelial barrier disruption in successful gene transfer to the colon. Gastroenterology. A1104-A1104. 1998
- Adenoviruses expressing cytokines can alter T cell differentiation and affect recovery against murine cutaneous leishmaniasis. The FASEB Journal. A572-A572. 1998
- Plasma cell vaccine production: Negative selection, adenoviral infection and in vivo expression of vector derived interleukin 2 (IL-2).. Blood. 1599-1599. 1997
- Combination therapy with IL-2 and wild-type p53 expressed by Ad-vectors induces tumor regression in vivo without cytokine related toxicity. Cancer Gene Therapy. P137-P137. 1997
- A high capacity adenovirus vector with all viral genes deleted results in improved in vivo expression and decreased toxicity. Cancer Gene Therapy. 328-328. 1997
- Interleukin-12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression. Cancer Gene Therapy. 317-318. 1997
- Tumour immunotherapy using an adenoviral vector expressing a membrane bound mutant of murine TNF. Cancer Gene Therapy. 300-301. 1997
- Adenovirus-Mediated Gene Transfer of the Proteoglycan Biglycan Induces Fibroblastic Responses in the Lung. Chest. 137S-137S. 1997
- In Vivo Adenovirus-Mediated Expression of Human Pre-Elafin, a Potent Neutrophil Elastase Inhibitor. Chest. 128S-129S. 1997
- Construction, function and in vivo expression of a complement receptor type 1 containing recombinant adenovirus for use in xenotransplantation. Transplantation Proceedings. 933-934. 1997
- Intradermal GM-CSF gene transfer in rat induces skin pathologies similar to chronic atopic dermatitis.. Journal of Allergy and Clinical Immunology. 1078-1078. 1997
- Adenovirus‐Vector‐Mediated Cytokine Gene Transfer to Lung Tissuea. Annals of the New York Academy of Sciences. 235-244. 1996
- Adenovirus vectors for gene expression and gene therapy. Transfusion and Apheresis Science. 15-27. 1996
- Adenovirus Vectors for Cytokine Gene Expression. Annals of the New York Academy of Sciences. 282-293. 1995
- 2ND-GENERATION ADENOVIRUS VECTORS FOR GENE-THERAPY. Journal of Cellular Biochemistry. 407-407. 1995
- ADENOVIRUS-BASED GENE-THERAPY FOR CITRULLINEMIA USING A MOUSE MODEL. Journal of Cellular Biochemistry. 369-369. 1995
- GENE TARGETING IN MOUSE EMBRYONIC STEM-CELLS WITH AN ADENOVIRAL VECTOR. Journal of Cellular Biochemistry. 411-411. 1995
- GENE-THERAPY OF CANCER USING RECOMBINANT ADENOVIRUS VECTORS EXPRESSING CYTOKINES. Journal of Cellular Biochemistry. 417-417. 1995
- IDENTIFICATION OF ADENOVIRUS E1A REGIONS WHICH AFFECT MHC CLASS-I EXPRESSION AND SUSCEPTIBILITY TO CTLS. Journal of Cellular Biochemistry. 292-292. 1995
- INHIBITION OF ANTIGEN PRESENTATION TO CD8+ T-LYMPHOCYTES BY HERPES-SIMPLEX VIRUS (HSV) IMMEDIATE-EARLY (IE) PROTEIN ICP47. Journal of Cellular Biochemistry. 272-272. 1995
- ADENOVIRAL VECTOR-MEDIATED GENE-TRANSFER INTO THE CELLS OF RAT LACRIMAL GLAND AND CONJUNCTIVE IN-VIVO. Experimental Hematology. 699-699. 1994
- RECOMBINANT ADENOVIRUS-MESSENGER RANTES GENE-TRANSFER INTO B16 MOUSE MELANOMA-CELLS REDUCES TUMORIGENICITY IN-VIVO. The FASEB Journal. A201-A201. 1994
- GENE-THERAPY OF CANCER USING CYTOKINE EXPRESSING RECOMBINANT ADENOVIRUS VECTORS. Journal of Cellular Biochemistry. 113-113. 1994
- TRANSDUCTION OF HUMAN BONE-MARROW BY ADENOVIRAL VECTOR. Journal of Cellular Biochemistry. 232-232. 1993
- CONSTRUCTION AND INVIVO EFFECTS OF A RECOMBINANT HUMAN ADENOVIRUS TYPE-5 EXPRESSING THE MURINE INTERLEUKIN-6 CDNA ON REPLICATION. The FASEB Journal. A1781-A1781. 1992
- IMMUNE-RESPONSE TO HIV-1 P24 INDUCED BY RECOMBINANT ADENOVIRUS VECTORS IN MICE AND RHESUS MACAQUE MONKEYS. CANADIAN JOURNAL OF INFECTIOUS DISEASES, VOL 3, SUPPLEMENT A, MAY 1992. A33-A34. 1992
- EXPRESSION OF A SINGLE ONCOGENE, ADENOVIRUS E1A, IN INFECTED AND TRANSFORMED-CELLS IS SUFFICIENT TO INDUCE SUSCEPTIBILITY TO LYSIS BY NK-CELLS AND ACTIVATED MACROPHAGES. Journal of Leukocyte Biology. 321-321. 1986
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journal articles
- HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in mice. Cancer Gene Therapy. 19:888-898. 2012
- Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the sentinel lymph nodes of mice. Journal of Translational Medicine. 8:98. 2010
- Attenuation of the Glucocorticoid Response during Ad5IL-12 Adenovirus Vector Treatment Enhances Natural Killer Cell–Mediated Killing of MHC Class I–Negative LNCaP Prostate Tumors. Cancer Research. 67:2290-2297. 2007
- A convenient plasmid system for construction of helper‐dependent adenoviral vectors and its application for analysis of the breast‐cancer‐specific mammaglobin promoter. Journal of Gene Medicine. 8:442-451. 2006
- Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus. Journal of General Virology. 87:641-650. 2006
- Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus. Journal of General Virology. 87:641-650. 2006
- Correction of chromosomal mutation and random integration in embryonic stem cells with helper-dependent adenoviral vectors. Proceedings of the National Academy of Sciences of the United States of America. 102:13628-13633. 2005
- SNPs in the neural cell adhesion molecule 1 gene (NCAM1) may be associated with human neural tube defects. Human Genetics. 117:133-142. 2005
- Use of a murine secreted alkaline phosphatase as a non‐immunogenic reporter gene in mice. Journal of Gene Medicine. 7:307-315. 2005
- Heterogeneity of the immune response to adenovirus‐mediated factor VIII gene therapy in different inbred hemophilic mouse strains. Journal of Gene Medicine. 6:1358-1368. 2004
- Life-long systemic protection in mice vaccinated with and adenovirus IL-12 vector requires active infection, macrophages and intact lymph nodes. Vaccine. 23:247-257. 2004
- The human SCGB2A2 (Mammaglobin-1) promoter/enhancer in a helper-dependent adenovirus vector directs high levels of transgene expression in mammary carcinoma cells but not in normal nonmammary cells. Molecular Therapy. 10:758-767. 2004
- Development of a size-restricted pIX-deleted helper virus for amplification of helper-dependent adenovirus vectors. Gene Therapy. 11:504-511. 2004
- Functional rescue of vitamin C synthesis deficiency in human cells using adenoviral-based expression of murine l-gulono-γ-lactone oxidase. Genomics. 83:482-492. 2004
- Helper-dependent adenoviral vectors mediate therapeutic factor VIII expression for several months with minimal accompanying toxicity in a canine model of severe hemophilia A. Blood. 103:804-810. 2004
- Factors influencing therapeutic efficacy and the host immune response to helper‐dependent adenoviral gene therapy in hemophilia A mice. Journal of Thrombosis and Haemostasis. 2:111-118. 2004
- Five novel mutations in the lysosomal sialidase gene (NEU1) in type II sialidosis patients and assessment of their impact on enzyme activity and intracellular targeting using adenovirus-mediated expression. Human Mutation. 23:32-39. 2004
- A phase I trial of adenovector-mediated delivery of interleukin-2 (AdIL-2) in high-risk localized prostate cancer. Cancer Gene Therapy. 10:755-763. 2003
- The use of three hemophilia A mouse models to illustrate strain-specific differences in immune responses to FVIII protein replacement via protein infusion or adenoviral gene therapy. Journal of Thrombosis and Haemostasis. 1:P0041-P0041. 2003
- Protection Against Experimental Autoimmune Encephalomyelitis Generated by a Recombinant Adenovirus Vector Expressing the Vβ8.2 TCR Is Disrupted by Coadministration with Vectors Expressing Either IL-4 or -10. Journal of Immunology. 170:765-774. 2003
- ErbB2 Is Required for Muscle Spindle and Myoblast Cell Survival. Molecular and Cellular Biology. 22:4714-4722. 2002
- Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. The FASEB Journal. 16:869-871. 2002
- Adenoviral-Mediated Gene Transfer of Lymphotactin to the Lungs of Mice and Rats Results in Infiltration and Direct Accumulation of CD4+, CD8+, and NK Cells. Journal of Interferon and Cytokine Research. 22:573-582. 2002
- Cre Levels Limit Packaging Signal Excision Efficiency in the Cre/ loxP Helper-Dependent Adenoviral Vector System. Journal of Virology. 76:4181-4189. 2002
- Superior Tissue-Specific Expression from Tyrosinase and Prostate-Specific Antigen Promoters/Enhancers in Helper-Dependent Compared with First-Generation Adenoviral Vectors. Human gene therapy. Clinical development. 13:211-224. 2002
- Construction of First-Generation Adenoviral Vectors. Methods in Molecular Medicine. 69:389-414. 2002
- Preparation of Helper-Dependent Adenoviral Vectors. Methods in Molecular Medicine. 69:371-388. 2002
- Adenovector engineered interleukin-2 expressing autologous plasma cell vaccination after high-dose chemotherapy for multiple myeloma - a phase 1 study. Leukemia. 15:846-854. 2001
- Development of a FLP/frt System for Generating Helper-Dependent Adenoviral Vectors. Molecular Therapy. 3:809-815. 2001
- Tricistronic viral vectors co-expressing interleukin-12 (1L-12) and CD80 (B7-1) for the immunotherapy of cancer: Preclinical studies in myeloma. Cancer Gene Therapy. 8:361-370. 2001
- Large Nontransplanted Hepatocellular Carcinoma in Woodchucks: Treatment With Adenovirus-Mediated Delivery of Interleukin 12/B7.1 Genes. Journal of the National Cancer Institute. 93:472-479. 2001
- Recombinant adenovirus vectors expressing interleukin‐5 and ‐6 specifically enhance mucosal immunoglobulin A responses in the lung. Immunology. 101:388-396. 2000
- Adenovirus vectors for high-efficiency gene transfer into mammalian cells. Trends in Immunology. 21:426-428. 2000
- Yeast Recombinase FLP Functions Effectively in Human Cells for Construction of Adenovirus Vectors. BioTechniques. 29:524-528. 2000
- Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons. Gene Therapy. 7:1200-1209. 2000
- An Enhanced System for Construction of Adenoviral Vectors by the Two-Plasmid Rescue Method. Human gene therapy. Clinical development. 11:693-699. 2000
- Toxicity Associated with Repeated Administration of First-Generation Adenovirus Vectors Does Not Occur with a Helper-Dependent Vector. Molecular Medicine. 6:179-195. 2000
- Adenoviral-mediated Gene Transfer to Mouse Salivary Glands. Journal of Dental Research. 79:701-708. 2000
- Adenovirus vectors for human gene therapy. Advances in Virus Research. 55:479-505. 2000
- A High-Efficiency Cre/loxP-Based System for Construction of Adenoviral Vectors. Human gene therapy. Clinical development. 10:2667-2672. 1999
- Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons. Proceedings of the National Academy of Sciences of the United States of America. 96:12816-12821. 1999
- Adenoviral Vector-Mediated Overexpression of IL-4 in the Knee Joint of Mice with Collagen-Induced Arthritis Prevents Cartilage Destruction. Journal of Immunology. 163:4546-4556. 1999
- Adenovirus Vector Expressing Mouse Oncostatin M Induces Acute-Phase Proteins and TIMP-1 ExpressionIn Vivoin Mice. Journal of Interferon and Cytokine Research. 19:1195-1205. 1999
- Effects of Stuffer DNA on Transgene Expression from Helper-Dependent Adenovirus Vectors. Journal of Virology. 73:8027-8034. 1999
- A p75 tumor necrosis factor receptor-specific mutant of murine tumor necrosis factor α expressed from an adenovirus vector induces an antitumor response with reduced toxicity. Cancer Gene Therapy. 6:465-474. 1999
- Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration. Gene Therapy. 6:1565-1573. 1999
- Human Gene Marker/Therapy Clincal Protocols (Complete Updated Listings). Human gene therapy. Clinical development. 10:2037-2088. 1999
- Use of a Liver-Specific Promoter Reduces Immune Response to the Transgene in Adenoviral Vectors. Human gene therapy. Clinical development. 10:1773-1781. 1999
- Transcription units of E1a, E1b and pIX regions of bovine adenovirus type 3.. Journal of General Virology. 80:1735-1742. 1999
- Autologous lymphocyte responses to adenovirus-B7-1-transduced human cancer cells. Cancer Gene Therapy. 6:195-208. 1999
- Adenoviral Vectors Expressing Lymphotactin and Interleukin 2 or Lymphotactin and Interleukin 12 Synergize to Facilitate Tumor Regression in Murine Breast Cancer Models. Human gene therapy. Clinical development. 10:697-709. 1999
- Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector. Proceedings of the National Academy of Sciences of the United States of America. 96:2615-2620. 1999
- Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21WAF1/CIP1 and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. Oncogene. 18:1663-1676. 1999
- Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial. Gene Therapy. 6:350-363. 1999
- Development and use of a 293 cell line expressing lac repressor for the rescue of recombinant adenoviruses expressing high levels of rabies virus glycoprotein.. Journal of General Virology. 80:345-353. 1999
- Transplanted hepatocytes infected with a complement receptor type 1 (CR1)-containing recombinant adenovirus are resistant to hyperacute rejection. Transplantation Proceedings. 31:939-939. 1999
- A Single Intramuscular Injection with an Adenovirus- Expressing IL-12 Protects BALB/c Mice AgainstLeishmania majorInfection, While Treatment with an IL-4-Expressing Vector Increases Disease Susceptibility in B10.D2 Mice. Journal of Immunology. 162:753-760. 1999
- High Doses of a Helper-Dependent Adenoviral Vector Yield Supraphysiological Levels ofα1-Antitrypsin with Negligible Toxicity. Human gene therapy. Clinical development. 9:2709-2716. 1998
- Enhanced Interleukin-2 Gene Transfer Immunotherapy of Breast Cancer by Coexpression of B7-1 and B7-2. Journal of Interferon and Cytokine Research. 18:927-937. 1998
- Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors. Gene Therapy. 5:1400-1409. 1998
- TRANSPLANTED HEPATOCYTES INFECTED WITH A COMPLEMENT RECEPTOR TYPE 1 (CR1)-CONTAINING RECOMBINANT ADENOVIRUS ARE RESISTANT TO HYPERACUTE REJECTION. Transplantation. 66:S9-S9. 1998
- Transfer of Tumor Necrosis Factor-α to Rat Lung Induces Severe Pulmonary Inflammation and Patchy Interstitial Fibrogenesis with Induction of Transforming Growth Factor-β1 and Myofibroblasts. American Journal of Pathology. 153:825-832. 1998
- The Himar1 mariner transposase cloned in a recombinant adenovirus vector is functional in mammalian cells. Nucleic Acids Research (NAR). 26:3687-3693. 1998
- An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene. Proceedings of the National Academy of Sciences of the United States of America. 95:7866-7871. 1998
- DEVELOPMENT OF PROSTATE-SPECIFIC ANTIGEN PROMOTER-BASED GENE THERAPY FOR ANDROGEN-INDEPENDENT HUMAN PROSTATE CANCER. Investigative Urology. 160:220-229. 1998
- DEVELOPMENT OF PROSTATE-SPECIFIC ANTIGEN PROMOTER-BASED GENE THERAPY FOR ANDROGEN-INDEPENDENT HUMAN PROSTATE CANCER. Journal of Urology. 160:220-229. 1998
- Transient Gene Transfer of IL-12 Regulates Chemokine Expression and Disease Severity in Experimental Arthritis. Journal of Immunology. 160:4615-4619. 1998
- Herpes Simplex Virus gD and Virions Accumulate in Endosomes by Mannose 6-Phosphate-Dependent and -Independent Mechanisms. Journal of Virology. 72:3330-3339. 1998
- Requirement for Both Shc and Phosphatidylinositol 3′ Kinase Signaling Pathways in Polyomavirus Middle T-Mediated Mammary Tumorigenesis. Molecular and Cellular Biology. 18:2344-2359. 1998
- Combination Therapy with Interleukin-2 and Wild-Type p53 Expressed by Adenoviral Vectors Potentiates Tumor Regression in a Murine Model of Breast Cancer. Human gene therapy. Clinical development. 9:707-718. 1998
- A Double Recombinant Adenovirus Expressing the Costimulatory Molecule B7-1 (Murine) and Human IL-2 Induces Complete Tumor Regression in a Murine Breast Adenocarcinoma Model. Journal of Immunology. 160:2531-2538. 1998
- Adenovirus-mediated expression of an elastase-specific inhibitor (elafin): a comparison of different promoters. Gene Therapy. 5:352-360. 1998
- Correction: Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nature Genetics. 18:298-298. 1998
- Tumour therapy in mice using adenovirus vectors expressing human TNFa.. International Journal of Oncology. 12:509-515. 1998
- Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nature Genetics. 18:180-183. 1998
- In Vivo Adenoviral-Mediated Gene Transfer of Interleukin-2 in Cutaneous Plasmacytoma. Blood. 91:1095-1097. 1998
- Efficient adenovirus-mediated gene expression in malignant human plasma cells: relative lymphoid cell resistance.. Experimental Hematology. 26:27-36. 1998
- Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease.. Journal of Clinical Investigation. 100:2766-2776. 1997
- Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions. Pneumologie. 51:396. 1997
- Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNFα. Gene Therapy. 4:1181-1188. 1997
- Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination. Gene Therapy. 4:1069-1076. 1997
- Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression. Proceedings of the National Academy of Sciences of the United States of America. 94:10889-10894. 1997
- Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.. Journal of Clinical Investigation. 100:768-776. 1997
- Construction and Characterization of a Replication-Deficient Adenovirus Expressing Rat-Soluble Interleukin-6 Receptor. Molecular Medicine. 3:519-529. 1997
- A Phase I Study of Adenovirus Mediated Gene Transfer of Interleukin 2 cDNA into Metastatic Breast Cancer or Melanoma. The Toronto Hospital, Toronto, Ontario, Canada. Human gene therapy. Clinical development. 8:1403-1414. 1997
- Dendritic Cells Transduced with an Adenoviral Vector Encoding a Model Tumor-Associated Antigen for Tumor Vaccination. Human gene therapy. Clinical development. 8:1355-1363. 1997
- Cloning and Sequencing of the Cellular–Viral Junctions from the Human Adenovirus Type 5 Transformed 293 Cell Line. Virology. 233:423-429. 1997
- Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors.. Journal of General Virology. 78:1653-1661. 1997
- Development and characterization of a binary gene expression system based on bacteriophage T7 components in adenovirus vectors. Gene. 193:129-140. 1997
- Transient Gene Transfer and Expression in the Lung. Chest. 111:89S-94S. 1997
- In vitro correction of iduronate-2-sulfatase deficiency by adenovirus-mediated gene transfer. Gene Therapy. 4:442-448. 1997
- Transgene-induced production of IL-4 alters the development and collagen expression of T helper cell 1-type pulmonary granulomas.. Journal of Immunology. 158:4478-4484. 1997
- A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging. Journal of Virology. 71:3293-3298. 1997
- Intramarrow Cytokine Gene Transfer by Adenoviral Vectors in Dogs. Human gene therapy. Clinical development. 8:545-553. 1997
- Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia. Gene Therapy. 4:140-149. 1997
- Human Adenovirus Vectors for Gene Transfer into Mammalian Cells. Advances in Pharmacology. 40:137-206. 1997
- Matrix Modulation Using Fibrogenic Gene Transfer. Inflammatory Bowel Diseases. 3:149-150. 1997
- Overexpression of RANTES using a recombinant adenovirus vector induces the tissue-directed recruitment of monocytes to the lung.. Journal of Immunology. 157:5076-5084. 1996
- A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal. Proceedings of the National Academy of Sciences of the United States of America. 93:13565-13570. 1996
- Production and characterization of human 293 cell lines expressing the site-specific recombinase Cre. Somatic Cell and Molecular Genetics. 22:477-488. 1996
- Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12. Human gene therapy. Clinical development. 7:1995-2002. 1996
- Adenoviral gene transfer of macrophage inflammatory protein-2 in rat lung.. American Journal of Pathology. 149:1395-1403. 1996
- IL-12 gene therapy protects mice in lethal Klebsiella pneumonia.. Journal of Immunology. 157:3006-3012. 1996
- Human adenovirus type 5 vectors expressing rabies glycoprotein. Vaccine. 14:1257-1264. 1996
- Testing NF-kappa B1-p50 antibody specificity using knockout mice.. Oncogene. 13:445-446. 1996
- Tropism of human adenovirus type 5-based vectors in swine and their ability to protect against transmissible gastroenteritis coronavirus. Journal of Virology. 70:3770-3780. 1996
- B7-1 gene transfer into human cancer cells by infection with an adenovirus-B7 (Ad-B7) expression vector. Annals of Surgical Oncology. 3:317-324. 1996
- Gene transfer for cytokine functional studies in the lung: the multifunctional role of GM-CSF in pulmonary inflammation. Journal of Leukocyte Biology. 59:481-488. 1996
- Adenoviral gene therapy for duchenne muscular dystrophy. Neuromuscular Disorders. 6:S24-S24. 1996
- Adenovirus vectors for gene expression and gene therapy. Transfusion and Apheresis Science. 17:15-27. 1996
- A comparison of human and murine cytomegalovirus promoters on gene expression in adult rat ocular tissues. Investigative Ophthalmology and Visual Science. 37. 1996
- Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions.. Journal of Clinical Investigation. 97:1102-1110. 1996
- Construction of a Double Recombinant Adenovirus Vector Expressing a Heterodimeric Cytokine:In VitroandIn VivoProduction of Biologically Active Interleukin-12. Human gene therapy. Clinical development. 7:333-342. 1996
- Patient selection may affect gene therapy success. Dominant negative effects observed for ornithine transcarbamylase in mouse and human hepatocytes.. Journal of Clinical Investigation. 97:826-832. 1996
- The first exon of Ad12 E1A excluding the transactivation domain mediates differential binding of COUP-TF and NF-kappa B to the MHC class I enhancer in transformed cells.. Oncogene. 12:143-151. 1996
- Pathology and immunogenicity in the cotton rat (Sigmodon hispidus) model after infection with a bovine adenovirus type 3 recombinant virus expressing the firefly luciferase gene. Journal of General Virology. 77:1-9. 1996
- AN ADENOVIRAL VECTOR EXPRESSING INTERLEUKIN-4 MODULATES TUMORIGENICITY AND INDUCES REGRESSION IN A MURINE BREAST-CANCER MODEL. International Journal of Oncology. 7:1253-1260. 1995
- Development of Cell Lines Capable of Complementing E1, E4, and Protein IX Defective Adenovirus Type 5 Mutants. Human gene therapy. Clinical development. 6:1575-1586. 1995
- DNA sequence of the deletion/insertion in early region 3 of Ad5 dl309. Virus Research. 39:75-82. 1995
- High frequency recombination betweenloxP sites in human chromosomes mediated by an adenovirus vector expressing Cre recombinase. Somatic Cell and Molecular Genetics. 21:429-441. 1995
- Induction of Antibodies Protecting against Transmissible Gastroenteritis Coronavirus (TGEV) by Recombinant Adenovirus Expressing TGEV Spike Protein. Virology. 213:503-516. 1995
- Recombinant Truncated Dystrophin Minigenes: Construction, Expression, and Adenoviral Delivery. Human gene therapy. Clinical development. 6:1477-1485. 1995
- Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model.. Proceedings of the National Academy of Sciences of the United States of America. 92:8522-8526. 1995
- Identification of Adenovirus E1A Regions Which Affect MHC Class I Expression and Susceptibility to Cytotoxic T Lymphocytes. Virology. 211:268-277. 1995
- Investigation of promoter function in human and animal cells infected with human recombinant adenoviruses expressing rotavirus antigen VP7sc. Journal of General Virology. 76:1971-1980. 1995
- Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression. Journal of Virology. 69:4600-4606. 1995
- Expression of a Mutation Causing Hypertrophic Cardiomyopathy Disrupts Sarcomere Assembly in Adult Feline Cardiac Myocytes. Circulation Research. 77:98-106. 1995
- Gene targeting in mouse embryonic stem cells with an adenoviral vector. Somatic Cell and Molecular Genetics. 21:221-231. 1995
- Foreign Gene Expression by Human Adenovirus Type 5-Based Vectors Studied Using Firefly Luciferase and Bacterial β-Galactosidase Genes as Reporters. Virology. 210:226-230. 1995
- Rescue, propagation, and partial purification of a helper virus-dependent adenovirus vector.. Proceedings of the National Academy of Sciences of the United States of America. 92:3854-3858. 1995
- Methods for construction of adenovirus vectors. Molecular Biotechnology. 3:207-220. 1995
- Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes.. Hepatology. 21:815-819. 1995
- 407-5 Expression of a Mutation Causing Hypertrophic Cardiomyopathy Disrupts Sarcomere Assembly in Adult Feline Cardiac Myocytes. Journal of the American College of Cardiology. 25:2A-2A. 1995
- Development of a bovine adenovirus type 3-based expression vector. Journal of General Virology. 76:93-102. 1995
- Mucosal immunization with a recombinant adenovirus vector induces local and systemic immunity and protection from herpes simplex virus.. Advances in Experimental Medicine and Biology. 371B:1581-1585. 1995
- Techniques for human adenovirus vector construction and characterization. Methods in Molecular Genetics. 7:13-30. 1995
- The use of adenoviral vectors for gene therapy and gene transfer in vivo. Current Opinion in Biotechnology. 6:590-595. 1995
- THE ADENOVIRUS E1A-ASSOCIATED P300 PROTEIN IS DIFFERENTIALLY PHOSPHORYLATED IN AD12 E1A-COMPARED TO AD5 E1A-TRANSFORMED RAT-CELLS. International Journal of Oncology. 5:1197-1205. 1994
- Adenovirus-mediated cytokine gene transfer at tissue sites. Overexpression of IL-6 induces lymphocytic hyperplasia in the lung.. Journal of Immunology. 153:4059-4069. 1994
- An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.. Proceedings of the National Academy of Sciences of the United States of America. 91:8802-8806. 1994
- Tissue directed recruitment of mononuclear cells to the lung using a recombinant adenovirus expressing murine RANTES. Cytokine. 6:544-544. 1994
- Transduction of Human Bone Marrow by Adenoviral Vector. Human gene therapy. Clinical development. 5:941-948. 1994
- A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes. Cell. 77:525-535. 1994
- ADENOVIRUS-MEDIATED GENE TRANSFER IN THE TRANSPLANT SETTING. Transplantation. 57:1502-1507. 1994
- ADENOVIRUS-MEDIATED GENE TRANSFER IN THE TRANSPLANT SETTING. Transplantation. 57:1502-1507. 1994
- Phosphorylation at the carboxy terminus of the 55-kilodalton adenovirus type 5 E1B protein regulates transforming activity. Journal of Virology. 68:776-786. 1994
- The E1 sequence of bovine adenovirus type 3 and complementation of human adenovirus type 5 E1A function in bovine cells. Virus Research. 31:163-186. 1994
- Tumorigenicity of adenovirus-transformed rodent cells is influenced by at least two regions of adenovirus type 12 early region 1A. Journal of Virology. 68:888-896. 1994
- Induction of an Immune Response to Transmissible Gastroenteritis Coronavirus Using Vectors with Enteric Tropism. Advances in Experimental Medicine and Biology. 342:455-462. 1994
- Corrigendum: Sequence analysis of bovine adenovirus type 3 early region 3 and fibre protein genes (Journal of General Virology (1992) 73 (3295-3300)). Journal of General Virology. 74:2825. 1993
- SEQUENCE-ANALYSIS OF BOVINE ADENOVIRUS TYPE-3 EARLY REGION-3 AND FIBER PROTEIN GENES (VOL 73, PG 3295, 1992). Journal of General Virology. 74:2825-2825. 1993
- Sequence analysis of bovine adenovirus type 3 early region 3 and fibre protein genes. - PubMed - NCBI. Journal of General Virology. 74:2825-2825. 1993
- Construction of recombinant human type 5 adenoviruses expressing rodent IL-6 genes. An approach to investigate in vivo cytokine function.. Journal of Immunology. 151:5145-5153. 1993
- INHIBITION OF CELL-PROLIFERATION BY AN ADENOVIRUS VECTOR EXPRESSING THE HUMAN WILD TYPE-P53 PROTEIN. International Journal of Oncology. 3:781-788. 1993
- Herpes Simplex Virus (HSV) Glycoproteins B and K Inhibit Cell Fusion Induced by HSV Syncytial Mutants. Virology. 196:514-531. 1993
- Mouse hepatitis virus spike and nucleocapsid proteins expressed by adenovirus vectors protect mice against a lethal infection. Journal of General Virology. 74:2061-2069. 1993
- Packaging capacity and stability of human adenovirus type 5 vectors. Journal of Virology. 67:5911-5921. 1993
- Efficient adenoviral-mediated ornithine transcarbamylase expression in deficient mouse and human hepatocytes.. Journal of Clinical Investigation. 92:1580-1586. 1993
- Mucosal Immunity and Protection after Intranasal Immunization with Recombinant Adenovirus Expressing Herpes Simplex Virus Glycoprotein B. Journal of Infectious Diseases. 168:622-629. 1993
- Monitoring foreign gene expression by a human adenovirus-based vector using the firefly luciferase gene as a reporter. Virus Research. 28:67-90. 1993
- Protective Immunity to Rotavirus-Induced Diarrhoea Is Passively Transferred to Newborn Mice from Naive Dams Vaccinated with a Single Dose of a Recombinant Adenovirus Expressing Rotavirus VP7sc. Virology. 193:940-950. 1993
- Immunogenicity in mice of tandem repeats of an epitope from herpes simplex gD protein when expressed by recombinant adenovirus vectors. Vaccine. 11:1191-1198. 1993
- Corrigendum. Virus Research. 26:279-279. 1992
- Sequence analysis of bovine adenovirus type 3 early region 3 and fibre protein genes. Journal of General Virology. 73:3295-3300. 1992
- Synthesis and Processing of the Haemagglutinin--esterase Glycoprotein of Bovine Coronavirus Encoded in the E3 Region of Adenovirus. Journal of General Virology. 73:2591-2600. 1992
- Identification and characterization of a novel herpes simplex virus glycoprotein, gK, involved in cell fusion. Journal of Virology. 66:5603-5609. 1992
- Recombinant human adenoviruses containing hybrid adenovirus type 5 (Ad5)/Ad12 E1A genes: characterization of hybrid E1A proteins and analysis of transforming activity and host range. Journal of Virology. 66:4117-4125. 1992
- Function and immunogenicity of human parainfluenza virus 3 glycoproteins expressed by recombinant adenoviruses. Virus Research. 24:21-33. 1992
- CELL-LINE TRANSFORMATION - A CITATION-CLASSIC COMMENTARY ON CHARACTERISTICS OF A HUMAN CELL-LINE TRANSFORMED BY DNA FROM HUMAN ADENOVIRUS TYPE-S BY GRAHAM,F.L., SMILEY,J., RUSSELL,W.C., AND NAIRN,R.. CURRENT CONTENTS/LIFE SCIENCES. 8-8. 1992
- Adenovirus-Based Expression Vectors and Recombinant Vaccines. Biotechnology. 20:363-390. 1992
- Transduction of the CHOaprt gene into mouse L cells using an adeno-5/APRT recombinant virus. Somatic Cell and Molecular Genetics. 17:359-368. 1991
- Isolation and characterization of insertion mutants in E1A of adenovirus type 5. Virology. 182:578-596. 1991
- The cleavage site of restriction endonuclease MnlI. Gene. 100:267-268. 1991
- Anti-adenovirus type 5 cytotoxic T lymphocytes: immunodominant epitopes are encoded by the E1A gene. Journal of Virology. 65:1450-1457. 1991
- Identification of an immunodominant cytotoxic T-lymphocyte recognition site in glycoprotein B of herpes simplex virus by using recombinant adenovirus vectors and synthetic peptides. Journal of Virology. 65:1177-1186. 1991
- Immune response to HIV-1 gag antigens induced by recombinant adenovirus vectors in mice and rhesus macaque monkeys.. Journal of Acquired Immune Deficiency Syndromes (1999). 4:568-576. 1991
- Manipulation of Adenovirus Vectors. Methods in molecular biology (Clifton, N.J.). 7:109-128. 1991
- Adenovirus E1A under the control of heterologous promoters: Wide variation in E1A expression levels has little effect on virus replication. Virology. 179:667-678. 1990
- Herpes simplex virus IgG Fc receptors induced using recombinant adenovirus vectors expressing glycoproteins E and I. Virology. 177:437-444. 1990
- Insertional mutagenesis using a synthetic lac operator. Gene. 87:155-155. 1990
- Cytotoxic T lymphocytes specific for herpes simplex virus (HSV) studied using adenovirus vectors expressing HSV glycoproteins. Journal of General Virology. 71:387-396. 1990
- A Recombinant Human Adenovirus Vaccine against Rabies. Journal of Infectious Diseases. 161:27-30. 1990
- Adenoviruses as expression vectors and recombinant vaccines. Trends in Biotechnology. 8:85-87. 1990
- Adenoviruses with nonidentical terminal sequences are viable. Journal of Virology. 63:5133-5141. 1989
- Insertional mutagenesis using a synthetic lac operator. Gene. 82:201-208. 1989
- Infectious circular DNA of human adenovirus type 5: regeneration of viral DNA termini from molecules lacking terminal sequences.. EMBO Journal. 8:2077-2085. 1989
- The effect of E1 mutations on biochemical transformation by an adenovirus carrying the herpes simplex virus thymidine kinase gene in region E3. Virus Research. 13:29-44. 1989
- Protection of mice against lethal challenge with herpes simplex virus by vaccination with an adenovirus vector expressing hsv glycoprotein B. Virology. 169:244-247. 1989
- Expression of the Glycoprotein of Vesicular Stomatitis Virus by Infectious Adenovirus Vectors. Journal of General Virology. 70:417-427. 1989
- Use of Human Adenovirus-based Vectors for Antigen Expression in Animals. Journal of General Virology. 70:429-434. 1989
- CITATION CLASSIC - A NEW TECHNIQUE FOR THE ASSAY OF INFECTIVITY OF HUMAN ADENOVIRUS-5 DNA. Current contents. Clinical medicine. 16-16. 1988
- CITATION CLASSIC - A NEW TECHNIQUE FOR THE ASSAY OF INFECTIVITY OF HUMAN ADENOVIRUS-5 DNA. CURRENT CONTENTS/LIFE SCIENCES. 16-16. 1988
- The expression of rhabdovirus antigens in human adenovirus vectors. Virus Research. 11:76-76. 1988
- Abundant expression of herpes simplex virus glycoprotein gB using an adenovirus vector. Virology. 164:1-14. 1988
- A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology. 163:614-617. 1988
- Stable transfer of a mouse dihydrofolate reductase gene into a deficient cell line using human adenovirus vector. Biochemical and Biophysical Research Communications. 147:964-973. 1987
- Protein IX, a minor component of the human adenovirus capsid, is essential for the packaging of full length genomes.. EMBO Journal. 6:1733-1739. 1987
- Growth of 293 Cells in Suspension Culture. Journal of General Virology. 68:937-940. 1987
- Expression of the adenovirus E1A oncogene during cell transformation is sufficient to induce susceptibility to lysis by host inflammatory cells.. Proceedings of the National Academy of Sciences of the United States of America. 83:6965-6969. 1986
- Characterization of an adenovirus type 5 mutant carrying embedded inverted terminal repeats. Virology. 153:22-34. 1986
- Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene. Journal of Virology. 57:267-274. 1986
- Human adenovirus cloning vectors based on infectious bacterial plasmids. Gene. 50:161-171. 1986
- Protein kinase and ATP-binding activity associated with the 72-kdalton single-stranded DNA-binding protein from early region 2A of human adenovirus type 5. Biochemistry and Cell Biology. 63:941-952. 1985
- Nonrandom insertion of Tn5 into cloned human adeno virus DNA. Gene. 40:31-38. 1985
- Covalently closed circles of human adenovirus DNA are infectious.. EMBO Journal. 3:2917-2922. 1984
- The Kinetics of Synthesis of Early Viral Proteins in KB Cells Infected with Wild-type and Transformation-defective Host-range Mutants of Human Adenovirus Type 5. Journal of General Virology. 65:585-597. 1984
- Establishment and characterization of hamster cell lines transformed by restriction endonuclease fragments of adenovirus 5. Journal of Virology. 49:162-170. 1984
- Transformation by human adenoviruses. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 780:67-94. 1984
- Transformation by human adenoviruses. Journal of cellular physiology. Supplement. 121:151-163. 1984
- Intracellular localization of adenovirus type 5 tumor antigens in productively infected cells. Virology. 129:456-468. 1983
- Characterization of human adenovirus type 5 early region 1A polypeptides using antitumor sera and an antiserum specific for the carboxy terminus. Virology. 127:253-271. 1983
- Transformation of rodent cells by DNA extracted from transformation-defective adenovirus mutants. Journal of Virology. 46:1039-1044. 1983
- Mapping of a 14,000-dalton antigen to early region 4 of the human adenovirus 5 genome. Journal of Virology. 45:514-523. 1983
- Covalently closed circles of adenovirus 5 DNA. Nature. 301:172-174. 1983
- Studies on transformation of mammalian cells by human adenovirus type 5 (Ad5) and Ad5 DNA.. Progress in Clinical and Biological Research. 132C:313-325. 1983
- Tn5 mutagenesis of the transforming genes of human adenovirus type 5. Gene. 19:33-42. 1982
- Integration and expression of viral DNA in cells transformed by host range mutants of adenovirus type 5. Journal of Virology. 41:674-685. 1982
- Complementation of adenovirus type 5 host range mutants by adenovirus type 12 in coinfected HeLa and BHK-21 cells. Journal of Virology. 38:191-197. 1981
- Protein kinase activity immunoprecipitated from adenovirus infected cells by sera from tumor-bearing hamsters. Journal of Virology. 37:601-608. 1981
- A rapid and efficient procedure for the purification of DNA from agarose gels. Analytical Biochemistry. 106:492-496. 1980
- Transforming Proteins of Human Adenovirus 5: Studies with Infected and Transformed Cells. Cold Spring Harbor Symposia on Quantitative Biology. 44:477-491. 1980
- [75] Assay of transforming activity of tumor virus DNA. Methods in Enzymology. 65:826-839. 1980
- Tumor antigens of human ad5 in transformed cells and in cells infected with transformation-defective host-range mutants. Cell. 18:781-791. 1979
- Tumorigenicity and viral gene expression in rat cells transformed by Ad 12 virions or by the EcoRI C fragment of Ad 12 DNA. Virology. 98:456-460. 1979
- Characterization of Human TK- Cell Lines Transformed to a TK+ Phenotype by Herpes Simplex Virus Type 2 DNA. Journal of General Virology. 42:149-157. 1979
- Immunoprecipitation of protein kinase activity from adenovirus 5-infected cells using antiserum directed against tumour antigens. Nature. 277:241-243. 1979
- Synthesis of DNA, late polypeptides, and infectious virus by host-range mutants of adenovirus 5 in nonpermissive cells. Virology. 87:463-467. 1978
- Defective transforming capacity of adenovirus type 5 host-range mutants. Virology. 86:10-21. 1978
- DNA-mediated transfer of herpes simplex virus TK gene to human TK- cells: properties of the transformed lines.. IARC (International Agency for Research on Cancer) Scientific Publications. No. 24:495-499. 1978
- Transformation with specific fragments of adenovirus DNAs I. Isolation of specific fragments with transforming activity of adenovirus 2 and 5 DNA. Gene. 2:115-132. 1977
- Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5. Journal of General Virology. 36:59-72. 1977
- Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by purified herpes simplex viral DNA.. Proceedings of the National Academy of Sciences of the United States of America. 74:1590-1594. 1977
- Host-range mutants of adenovirus type 5 defective for growth in HeLa cells. Virology. 77:319-329. 1977
- Biological Activity of Tumor Virus Dna. Advances in Cancer Research. 25:1-51. 1977
- Relation of Herpes Simplex Viruses to Human Malignancies. Current Topics in Microbiology and Immunology. 77:71-95. 1977
- Size and location of the transforming region in human adenovirus type 5 DNA. Nature. 251:687-691. 1974
- Studies on In Vitro Transformation by DNA and DNA Fragments of Human Adenoviruses and Simian Virus 40. Cold Spring Harbor Symposia on Quantitative Biology. 39:637-650. 1974
- Infectious Herpesvirus DNA. Nature. 245:265-266. 1973
- Transformation of rat cells by DNA of human adenovirus 5. Virology. 54:536-539. 1973
- A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology. 52:456-467. 1973
- Sedimentation Analysis of DNA from Irradiated and Unirradiated L Cells. Biophysical Journal. 12:369-383. 1972
- Anomalous sedimentation of high molecular weight denatured mammalian DNA. Biochemical and Biophysical Research Communications. 44:171-177. 1971
- Studies in mouse L-cells on the incorporation of 1-beta-D-arabinofuranosylcytosine into DNA and on inhibition of DNA polymerase by 1-beta-D-arabinofuranosylcytosine 5'-triphosphate.. Cancer Research. 30:2636-2644. 1970
- The effect of-beta-D-arabinofuranosylcytosine on growth, viability, and DNA synthesis of mouse L-cells.. Cancer Research. 30:2627-2635. 1970
-
other
- [2] Techniques for human adenovirus vector construction and characterization. Methods in Molecular Genetics. 13-30. 1995