Journal article
Differential immune responses mediated by adenovirus- and lentivirus-transduced DCs in a HER-2/neu overexpressing tumor model
Abstract
Recent investigations have demonstrated that adenoviral and lentiviral vectors encoding HER-2 can be utilized in cancer immunotherapy. However, it is not known whether both viral systems elicit a similar immune response. Here, we compare the immune response in mice induced by dendritic cells (DCs) infected with either recombinant adenovirus or lentivirus encoding rat HER-2 (rHER-2). Both vaccine types yielded similar control of tumor growth, …
Authors
Felizardo TC; Wang JCM; McGray RAJ; Evelegh C; Spaner DE; Fowler DH; Bramson JL; Medin JA
Journal
Gene Therapy, Vol. 18, No. 10, pp. 986–995
Publisher
Springer Nature
Publication Date
October 2011
DOI
10.1038/gt.2011.53
ISSN
0969-7128