Journal article
Molecular Pathways: Epigenetic Modulation of Wnt–Glycogen Synthase Kinase-3 Signaling to Target Human Cancer Stem Cells
Abstract
Aberrant regulation of the canonical Wnt signaling pathway (Wnt-β-catenin-GSK3 axis) has been a prevalent theme in cancer biology since earlier observations until recent genetic discoveries gleaned from tumor genome sequencing. During the last few decades, a large body of work demonstrated the involvement of the Wnt-β-catenin-GSK3 signaling axis in the formation and maintenance of cancer stem cells (CSC) responsible for tumor growth in several …
Authors
Benoit YD; Guezguez B; Boyd AL; Bhatia M
Journal
Clinical Cancer Research, Vol. 20, No. 21, pp. 5372–5378
Publisher
American Association for Cancer Research (AACR)
Publication Date
November 1, 2014
DOI
10.1158/1078-0432.ccr-13-2491
ISSN
1078-0432