Journal article
Effect of alkyl-N-purine DNA glycosylase overexpression on cellular resistance to bifunctional alkylating agents
Abstract
Increased activity of alkyl-N-purine DNA glycosylase (ANPG; a.k.a. N3-methyladenine DNA glycosylase) has been correlated with resistance to both chloroethylnitrosoureas and nitrogen mustards. Also, overexpression of the human glycosylase in Escherichia coli results in resistance to alkylating agents. To determine how overexpression of the protein affects resistance to these bifunctional alkylating agents in mammalian cells, wild-type CHO-AA8 …
Authors
Bramson J; O'Connor T; Panasci L
Journal
Biochemical Pharmacology, Vol. 50, No. 1, pp. 39–44
Publisher
Elsevier
Publication Date
June 1995
DOI
10.1016/0006-2952(95)00114-f
ISSN
0006-2952